Towards Laser Driven Hadron Cancer Radiotherapy: A Review of Progress

It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumours. It has an innate ability to irradiate tumours with greater doses and spatial selectivity compared with electron and photon therapy and hence is a tissue sparing procedure. For more than twenty years powerful lasers have generated high energy beams of protons and heavy ions and hence it has been frequently speculated that lasers could be used as an alternative to RF accelerators to produce the particle beams necessary for cancer therapy. The present paper reviews the progress made towards laser driven hadron cancer therapy and what has still to be accomplished to realise its inherent enormous potential.Comment: 40 pages, 24 figure

The Structure & Dynamics of Massive Early-type Galaxies: On Homology, Isothermality and Isotropy inside one Effective Radius

Based on 58 SLACS strong-lens early-type galaxies with direct total-mass and stellar-velocity dispersion measurements, we find that inside one effective radius massive elliptical galaxies with M_eff >= 3x10^10 M_sun are well-approximated by a power-law ellipsoid with an average logaritmic density slope of = -dlog(rho_tot)/dlog(r)=2.085^{+0.025}_{-0.018} (random error on mean) for isotropic orbits with beta_r=0, +-0.1 (syst.) and sigma_gamma' <= 0.20^{+0.04}_{-0.02} intrinsic scatter (all errors indicate the 68 percent CL). We find no correlation of gamma'_LD with galaxy mass (M_eff), rescaled radius (i.e. R_einst/R_eff) or redshift, despite intrinsic differences in density-slope between galaxies. Based on scaling relations, the average logarithmic density slope can be derived in an alternative manner, fully independent from dynamics, yielding =1.959 +- 0.077. Agreement between the two values is reached for =0.45 +- 0.25, consistent with mild radial anisotropy. This agreement supports the robustness of our results, despite the increase in mass-to-light ratio with total galaxy mass: M_eff ~ L_{V,eff}^(1.363+-0.056). We conclude that massive early-type galaxies are structurally close-to homologous with close-to isothermal total density profiles (<=10 percent intrinsic scatter) and have at most some mild radial anisotropy. Our results provide new observational limits on galaxy formation and evolution scenarios, covering four Gyr look-back time.Comment: Accepted for publication by ApJL; 4 pages, 2 figure

The Sloan Lens ACS Survey. IX. Colors, Lensing and Stellar Masses of Early-type Galaxies

We present the current photometric dataset for the Sloan Lens ACS (SLACS) Survey, including HST photometry from ACS, WFPC2, and NICMOS. These data have enabled the confirmation of an additional 15 grade `A' (certain) lens systems, bringing the number of SLACS grade `A' lenses to 85; including 13 grade `B' (likely) systems, SLACS has identified nearly 100 lenses and lens candidates. Approximately 80% of the grade `A' systems have elliptical morphologies while ~10% show spiral structure; the remaining lenses have lenticular morphologies. Spectroscopic redshifts for the lens and source are available for every system, making SLACS the largest homogeneous dataset of galaxy-scale lenses to date. We have developed a novel Bayesian stellar population analysis code to determine robust stellar masses with accurate error estimates. We apply this code to deep, high-resolution HST imaging and determine stellar masses with typical statistical errors of 0.1 dex; we find that these stellar masses are unbiased compared to estimates obtained using SDSS photometry, provided that informative priors are used. The stellar masses range from 10^10.5 to 10^11.8 M$_\odot$ and the typical stellar mass fraction within the Einstein radius is 0.4, assuming a Chabrier IMF. The ensemble properties of the SLACS lens galaxies, e.g. stellar masses and projected ellipticities, appear to be indistinguishable from other SDSS galaxies with similar stellar velocity dispersions. This further supports that SLACS lenses are representative of the overall population of massive early-type galaxies with M* >~ 10^11 M$_\odot$, and are therefore an ideal dataset to investigate the kpc-scale distribution of luminous and dark matter in galaxies out to z ~ 0.5.Comment: 20 pages, 18 figures, 5 tables, published in Ap

Nonlinear Scattering of a Bose-Einstein Condensate on a Rectangular Barrier

We consider the nonlinear scattering and transmission of an atom laser, or Bose-Einstein condensate (BEC) on a finite rectangular potential barrier. The nonlinearity inherent in this problem leads to several new physical features beyond the well-known picture from single-particle quantum mechanics. We find numerical evidence for a denumerably infinite string of bifurcations in the transmission resonances as a function of nonlinearity and chemical potential, when the potential barrier is wide compared to the wavelength of oscillations in the condensate. Near the bifurcations, we observe extended regions of near-perfect resonance, in which the barrier is effectively invisible to the BEC. Unlike in the linear case, it is mainly the barrier width, not the height, that controls the transmission behavior. We show that the potential barrier can be used to create and localize a dark soliton or dark soliton train from a phonon-like standing wave.Comment: 15 pages, 15 figures, new version includes clarification of definition of transmission coefficient in general nonlinear vs. linear cas

PKS B1400-33: an unusual radio relic in a poor cluster

We present new arcminute resolution radio images of the low surface brightness radio source PKS B1400-33 that is located in the poor cluster Abell S753. The observations consist of 330 MHz VLA, 843 MHz MOST and 1398 and 2378 MHz ATCA data. These new images, with higher surface brightness sensitivity than previous observations, reveal that the large scale structure consists of extended filamentary emission bounded by edge-brightened rims. The source is offset on one side of symmetrically distributed X-ray emission that is centered on the dominant cluster galaxy NGC 5419. PKS B1400-33 is a rare example of a relic in a poor cluster with radio properties unlike those of most relics and halos observed in cluster environments. The diffuse source appears to have had an unusual origin and we discuss possible mechanisms. We examine whether the source could be re-energized relic radio plasma or a buoyant synchrotron bubble that is a relic of activity in NGC 5419. The more exciting prospect is that the source is relic plasma preserved in the cluster gaseous environment following the chance injection of a radio lobe into the ICM as a result of activity in a galaxy at the periphery of the cluster.Comment: 26 pages, 8 figures, accepted for publication in the Astronomical Journa

Forehead Skin Blood Flow in Normal Neonates during Active and Quiet Sleep, Measured with a Diode Laser Doppler Instrument

Changes in forehead skin blood flow during active and quiet sleep were determined in 16 healthy neonates using a recently developed semi-conductor laser Doppler flow meter without light conducting fibres. Measurements were carried out at a postnatal age varying from 5 hours to 7 days. The two sleep states could be distinguished in 17 recordings. The mean skin blood flow values during active sleep were significantly higher (p<0.01) than those during quiet sleep, the mean increase being 28.1%. The variability of the flow signal, expressed as the coefficient of variation, changed significantly from 23.1% during active sleep to 18.2% during quiet sleep

K_L \ra \mu^\pm e^\mp \nu \overline{\nu} as background to K_L \ra \mu^\pm e^\mp

We consider the process K_L \ra \mu^\pm e^\mp \nu \overline{\nu} at next to leading order in chiral perturbation theory. This process occurs in the standard model at second order in the weak interaction and constitutes a potential background in searches for new physics through the modes K_L \ra \mu^\pm e^\mp. We find that the same cut, $M_{\mu e}>489$~MeV, used to remove the sequential decays K_{l3}\ra \pi_{l2} pushes the B(K_L \ra \mu^\pm e^\mp \nu \overline{\nu}) to the $10^{-23}$ level, effectively removing it as a background.Comment: 8 pages, LaTeX, 1 figure appended as postscript file after \end{document}. Fermilab-Pub-93/024-

The Sloan Lens ACS Survey. XI. Beyond Hubble resolution: size, luminosity and stellar mass of compact lensed galaxies at intermediate redshift

We exploit the strong lensing effect to explore the properties of intrinsically faint and compact galaxies at intermediate redshift, at the highest possible resolution at optical wavelengths. Our sample consists of 46 strongly-lensed emission line galaxies discovered by the Sloan Lens ACS (SLACS) Survey. The galaxies have been imaged at high resolution with HST in three bands (V_HST, I_814 and H_160), allowing us to infer their size, luminosity, and stellar mass using stellar population synthesis models. Lens modeling is performed using a new fast and robust code, klens, which we test extensively on real and synthetic non-lensed galaxies, and also on simulated galaxies multiply-imaged by SLACS- like galaxy-scale lenses. Our tests show that our measurements of galaxy size, flux, and Sersic index are robust and accurate, even for objects intrinsically smaller than the HST point spread function. The median magnification is 8.8, with a long tail that extends to magnifications above 40. Modeling the SLACS sources reveals a population of galaxies with colors and Sersic indices (median n ~ 1) consistent with the objects detected in the field with HST in the GEMS survey, but that are (typically) ~ 2 magnitudes fainter and ~ 5 times smaller in apparent size. The closest analog are ultracompact emission line galaxies identified by HST grism surveys. The lowest mass galaxies in our sample are comparable to the brightest Milky Way satellites in stellar mass (10^7 solar masses) and have well-determined half light radii of 0."05 (~0.3 kpc).Comment: 19 pages, 12 figures, 6 tables, accepted for publication in Ap

Charmed-Baryon Spectroscopy from Lattice QCD with N_f=2+1+1 Flavors

We present the results of a calculation of the positive-parity ground-state charmed-baryon spectrum using 2+1+1 flavors of dynamical quarks. The calculation uses a relativistic heavy-quark action for the valence charm quark, clover-Wilson fermions for the valence light and strange quarks, and HISQ sea quarks. The spectrum is calculated with a lightest pion mass around 220 MeV, and three lattice spacings (a \approx 0.12 fm, 0.09 fm, and 0.06 fm) are used to extrapolate to the continuum. The light-quark mass extrapolation is performed using heavy-hadron chiral perturbation theory up to O(m_pi^3) and at next-to-leading order in the heavy-quark mass. For the well-measured charmed baryons, our results show consistency with the experimental values. For the controversial J=1/2 Xi_{cc}, we obtain the isospin-averaged value M_{Xi_{cc}}=3595(39)(20)(6) MeV (the three uncertainties are statistics, fitting-window systematic, and systematics from other lattice artifacts, such as lattice scale setting and pion-mass determination), which shows a 1.7 sigma deviation from the experimental value. We predict the yet-to-be-discovered doubly and triply charmed baryons Xi_{cc}^*, Omega_{cc}, Omega_{cc}^* and Omega_{ccc} to have masses 3648(42)(18)(7) MeV, 3679(40)(17)(5) MeV, 3765(43)(17)(5) MeV and 4761(52)(21)(6) MeV, respectively.Comment: 23 pages, 14 figure

The Sloan Lens ACS Survey. X. Stellar, Dynamical, and Total Mass Correlations of Massive Early-type Galaxies

We use stellar masses, photometry, lensing, and velocity dispersions to investigate empirical correlations for the final sample of 73 early-type lens galaxies (ETGs) from the SLACS survey. The traditional correlations (Fundamental Plane [FP] and its projections) are consistent with those found for non-lens galaxies, supporting the thesis that SLACS lens galaxies are representative of massive ETGs. The addition of strong lensing estimates of the total mass allows us to gain further insights into their internal structure: i) the mean slope of the total mass density profile is = 2.078+/-0.027 with an intrinsic scatter of 0.16+/-0.02; ii) gamma' correlates with effective radius and central mass density, in the sense that denser galaxies have steeper profiles; iii) the dark matter fraction within reff/2 is a monotonically increasing function of galaxy mass and size; iv) the dimensional mass M_dim is proportional to the total mass, and both increase more rapidly than stellar mass M*; v) the Mass Plane (MP), obtained by replacing surface brightness with surface mass density in the FP, is found to be tighter and closer to the virial relation than the FP and the M*P, indicating that the scatter of those relations is dominated by stellar population effects; vi) we construct the Fundamental Hyper-Plane by adding stellar masses to the MP and find the M* coefficient to be consistent with zero and no residual intrinsic scatter. Our results demonstrate that the dynamical structure of ETGs is not scale invariant and that it is fully specified by the total mass, r_eff, and sigma. Although the basic trends can be explained qualitatively in terms of varying star formation efficiency as a function of halo mass and as the result of dry and wet mergers, reproducing quantitatively the observed correlations and their tightness may be a significant challenge for galaxy formation models.Comment: 16 pages, 9 figures; submitted to ApJ after responding to the referee comment