12 research outputs found
5-YEAR SURVIVAL OF PATIENTS WITH STAGE II UTERINE CANCER DEPENDING ON MORPHOLOGIC FEATURES OF TUMOR
Retrospective data of treatment results of 109 patients with rarely observed stage II uterine cancer, admitted to N.N. Blokhin Russian Cancer Research Center from 1980 to 2000 is analyzed. Correlation of overall 5-year survival rates of stage IIA and IIB uterine can- cer patients with a number of tumor morphologic features is studied. The influence of some non-elucidated morphologic features of stage IIA and IIB uterine cancer such as the degree of cellular anaplasia, the depth of tumor invasion into the uterine neck, lymho- vascular invasion into the myometrium and uterine neck, microscopic vessels density in the area of the most extensive invasion, the presence of necrotic areas in the tumor tissue on long-term treatment results are analyzed
CLINICAL CHARACTERISTICS OF OVARIAN CLEAR CELL CANCER
The research has enrolled 96 patients with rare ovarian clear cell cancer treated at N.N. Blokhin Russian Cancer Research Center from 1978 to 2000. A necessity to divide patients into two groups has emerged after histopathological slide review. The first group included 71 patients with ovarian clear cell carcinoma (OCCC). Twenty five patients with mixed malignant epithelial ovarian tumor (MMEOT) with mandatory presence of clear cell component were included into the second group. Clinical par- ticularities of clear cell ovarian cancer were studied. We performed a comparative study of clinical course of OCCC and MMEOT. Our data suggest that clear cell ovarian cancer has a number of typical clinical and biological particularities both in OCCC and MMEOT
Impact of the morphological signs of Stage II corpus uteri cancer on the occurrence of recurrences and metastases
The paper gives the rates of recurrences and metastases occurring after primary therapy in 109 patients with Stage II corpus uteri cancer (CUC) treated at the Unit of Gynecology, N.N. Blokhin Russian Cancer Research Center.The distribution of patients with Stages IIA and IIB CUC is shown by the rates of recurrences and metastases; the time of their emergence is defined; the mean survival is estimated in patients with progressive CUC. The distribution of patients with recurrent Stage II CUC and separately its metastases is considered in relation to the early unstudied morphological characteristics of primary tumor
The pathomorphological characteristics of clear-cell adenocarcinomas of the ovary and its mixed tumors with a clear-cell component
Objective: to study the pathomorphological signs of pure and mixed clear-cell ovarian tumors with a clear-cell component.Subjects and methods. The clinical and morphological characteristics and the course of the disease were analyzed in 96 patients aged 21 to 75 years with clear-cell ovarian carcinoma. All the patients were divided into 2 groups: 1) 71 patients with pure clear-cell ovarian adenocarcinomas (COA) and 2) 25 patients with mixed malignant ovarian epithelial tumors (MMOET) with an obligatory clear-cell component. All pure forms of ovarian clear-cell malignancies were represented by adenocarcinoma in our study. This histologic type of the tumor was also prevalent among mixed ovarian neoplasms.Results. Clear, optically transparent cells and shoe nail-type (nail) ones were most common in COA. MMOETs showed moderate dif- ferentiation and malignancy and moderate atypia of a cell. Pure clear-cell neoplasms generally displayed 3 to 6 mitoses in 10 fields of vision whereas MMOET exhibited as many as 3 mitoses in 10 fields of vision
Treatment results and prognostic factors of clear cell ovarian carcinomas and ovarian carcinomas with clear cell component
The most important prognostic factors for clear cell carcinoma (CCC) are clinical and morphological signs and clinical stage of the disease. Analyses of 5-year survival in patients with I stage of CCC is 69 %, in II stage – 55 %, in III stage – 14 % and in IV stage – 4 % patients. We analyzed distant results of treatment of 71 patients with CCC and of 25 patients with mixed malignant ovaries neoplasm with obligatory clear cell component taking into consideration main clinical and morphological sings of disease. On the base of performed reseal we revealed that morphological structure of the tumors and stage of the disease exerted heist influence on the exponent of survival of the patients with clear CCC ovaries neoplasm. Besides, there is a correlation between exponent of patients’ survival and radicalized of surgery, character of tumor growth, differentiation degree, cell anaplasia and mitotic activity of tumor cells