734 research outputs found
Collective Excitations of (154)Sm nucleus at FEL{gamma}+LHC Collider
The production of collective excitations of the (154)Sm at FEL{gamma}+LHC
collider is investigated. We show that this machine will be a powerful tool for
investigation of high energy level excitations.Comment: 6 pages, 1 figure, 4 table
Competing electric and magnetic excitations in backward electron scattering from heavy deformed nuclei
Important contributions to the cross sections of
low-lying orbital excitations are found in heavy deformed nuclei, arising
from the small energy separation between the two excitations with and 1, respectively. They are studied microscopically in QRPA using
DWBA. The accompanying response is negligible at small momentum transfer
but contributes substantially to the cross sections measured at for fm ( MeV)
and leads to a very good agreement with experiment. The electric response is of
longitudinal type for but becomes almost purely
transverse for larger backward angles. The transverse response
remains comparable with the response for fm
( MeV) and even dominant for MeV. This happens even at
large backward angles , where the dominance is
limited to the lower region.Comment: RevTeX, 19 pages, 8 figures included Accepted for publication in Phys
Rev
Medical education reform in Tajikistan: comparison of the conventional one-year family medicine residency program and the new two-year residency program for postgraduate medical education
INTRODUCTION: The last two decades have seen a shift in former Soviet countries from highly specialized to more family medicine-focused systems. Medical education has slowly adjusted to these reforms, although the region is still at risk to have a chronic shortage of family doctors. This paper presents the evaluation of a new post-graduate family medicine program in Tajikistan, focused on competency-based training. The findings are relevant for policy makers, international organizations and practitioners participating in similar medical education reform programs. METHODS: We employed a quasi-experimental control group design and compared intervention residents, control group residents with traditional training, and 1st year residents with no training in two outcomes, clinical knowledge and competencies. We employed two objective measures, a written multiple-choice question test (MCQT) and an Objective Structured Clinical Examination (OSCE), respectively. We report reliability and validity of the measures along with ANOVA, planned contrasts and effect size estimates to examine differences across groups. RESULTS: We found statistically significant differences in both clinical knowledge and competencies between intervention and control groups. We also detected a large intervention effect size. Participants in the intervention outperformed control group participants in the two measures. Our analysis suggests that intervention and control group participants are comparable in terms of initial knowledge and competencies, strengthening the argument that the intervention caused the improvement in the program outcomes. DISCUSSION: Receiving tailored training and structured opportunities to practice knowledge and competencies in clinical settings have a positive effect on the education of family medicine doctors in Tajikistan. Our results support curriculum reform and investment in medical education in the form of longer and supervised on-the-job preparation designed to be more in line with international standards. We discuss suggestions for future studies and potential requirements to inform replicability in other countries. CONCLUSION: Family medicine is well recognized as central to health systems throughout the world, but high quality residency training lags behind in some countries. Our study showed that investing in family medicine residency programs and structured training is effective in increasing critical clinical competencies. We encourage promoting comprehensive post graduate family medicine doctor training so that the goals of a family medicine centered health system are attainable
Orbital Magnetic Dipole Mode in Deformed Clusters: A Fully Microscopic Analysis
The orbital M1 collective mode predicted for deformed clusters in a schematic
model is studied in a self-consistent random-phase-approximation approach which
fully exploits the shell structure of the clusters. The microscopic mechanism
of the excitation is clarified and the close correlation with E2 mode
established. The study shows that the M1 strength of the mode is fragmented
over a large energy interval. In spite of that, the fraction remaining at low
energy, well below the overwhelming dipole plasmon resonance, is comparable to
the strength predicted in the schematic model. The importance of this result in
view of future experiments is stressed.Comment: 10 pages, 3 Postscript figures, uses revte
Universality of Symmetry and Mixed-symmetry Collective Nuclear States
The global correlation in the observed variation with mass number of the
and summed transition strengths is examined for rare earth nuclei. It is
shown that a theory of correlated and fermion pairs with a simple
pairing plus quadrupole interaction leads naturally to this universality. Thus
a unified and quantitative description emerges for low-lying quadrupole and
dipole strengths.Comment: In press, Phys. Rev. Lett. 199
Temperature Dependence of Damping and Frequency Shifts of the Scissors Mode of a trapped Bose-Einstein Condensate
We have studied the properties of the scissors mode of a trapped
Bose-Einstein condensate of Rb atoms at finite temperature. We measured
a significant shift in the frequency of the mode below the hydrodynamic limit
and a strong dependence of the damping rate as the temperature increased. We
compared our damping rate results to recent theoretical calculations for other
observed collective modes finding a fair agreement. From the frequency
measurements we deduce the moment of inertia of the gas and show that it is
quenched below the transition point, because of the superfluid nature of the
condensed gas.Comment: 5 pages, 4 figure
Scissors modes in triaxial metal clusters
We study the scissors mode (orbital M1 excitations) in small Na clusters,
triaxial metal clusters and and the
close-to-spherical , all described in DFT with detailed ionic
background. The scissors modes built on spin-saturated ground and
spin-polarized isomeric states are analyzed in virtue of both macroscopic
collective and microscopic shell-model treatments. It is shown that the mutual
destruction of Coulomb and the exchange-correlation parts of the residual
interaction makes the collective shift small and the net effect can depend on
details of the actual excited state. The crosstalk with dipole and spin-dipole
modes is studied in detail. In particular, a strong crosstalk with spin-dipole
negative-parity mode is found in the case of spin-polarized states. Triaxiality
and ionic structure considerably complicate the scissors response, mainly at
expense of stronger fragmentation of the strength. Nevertheless, even in these
complicated cases the scissors mode is mainly determined by the global
deformation. The detailed ionic structure destroys the spherical symmetry and
can cause finite M1 response (transverse optical mode) even in clusters with
zero global deformation. But its strength turns out to be much smaller than for
the genuine scissors modes in deformed systems.Comment: 17 pages, 5 figure
Magnetic Dipole Sum Rules for Odd-Mass Nuclei
Sum rules for the total- and scissors-mode M1 strength in odd-A nuclei are
derived within the single-j interacting boson-fermion model. We discuss the
physical content and geometric interpretation of these sum rules and apply them
to ^{167}Er and ^{161}Dy. We find consistency with the former measurements but
not with the latter.Comment: 13 pages, Revtex, 1 figure, Phys. Rev. Lett. in pres
Hypoxia-induced downregulation of microRNA-186-5p in endothelial cells promotes non-small cell lung cancer angiogenesis by upregulating protein kinase C alpha
The tumor microenvironment stimulates the angiogenic activity of endothelial cells (ECs) to facilitate tumor vascularization,
growth, and metastasis. The involvement of microRNA-186-5p
(miR-186) in regulating the aberrant activity of tumor-associated ECs has so far not been clarified. In the present study,
we demonstrated that miR-186 is significantly downregulated
in ECs microdissected from human non-small cell lung cancer
(NSCLC) tissues compared with matched non-malignant lung
tissues. In vitro analyses of primary human dermal microvascular ECs (HDMECs) exposed to different stimuli indicated
that this miR-186 downregulation is triggered by hypoxia
via activation of hypoxia-inducible factor 1 alpha (HIF1a).
Transfection of HDMECs with miR-186 mimic (miR-186m)
significantly inhibited their proliferation, migration, tube
formation, and spheroid sprouting. In contrast, miR-186
inhibitor (miR-186i) exerted pro-angiogenic effects. In vivo,
endothelial miR-186 overexpression inhibited the vascularization of Matrigel plugs and the initial growth of tumors
composed of NSCLC cells (NCI-H460) and HDMECs. Mechanistic analyses revealed that the gene encoding for protein
kinase C alpha (PKCa) is a bona fide target of miR-186. Activation of this kinase significantly reversed the miR-186mrepressed angiogenic activity of HDMECs. These findings
indicate that downregulation of miR-186 in ECs mediates hypoxia-stimulated NSCLC angiogenesis by upregulating PKCa
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