Swimming upstream: input-output linkages and thedirection of product adoption

Multiproduct firms dominate production, and their product turnover contributes substantially to aggregate growth. Firms continually adapt their product mix, but what determines which products firms expand into? Theories of the firm propose that mulitproduct firms choose to make products which need the same know-how or inputs that can't be bought ‘off the shelf’. We empirically examine this rationale by testing for firm-level capabilities that are shared across products and manifested through input-output (IO) linkages. We show that a firm's idiosyncratic horizontal and vertical similarity to a product's IO structure predicts product adoption. Using product-specific policy changes for a firm's inputs and outputs, we show that input linkages are the most important, suggesting that firms' product capabilities depend more on economies of scope rather than product market complementarities

A theoretical and semiemprical correction to the long-range dispersion power law of stretched graphite

In recent years intercalated and pillared graphitic systems have come under increasing scrutiny because of their potential for modern energy technologies. While traditional \emph{ab initio} methods such as the LDA give accurate geometries for graphite they are poorer at predicting physicial properties such as cohesive energies and elastic constants perpendicular to the layers because of the strong dependence on long-range dispersion forces. `Stretching' the layers via pillars or intercalation further highlights these weaknesses. We use the ideas developed by [J. F. Dobson et al, Phys. Rev. Lett. {\bf 96}, 073201 (2006)] as a starting point to show that the asymptotic $C_3 D^{-3}$ dependence of the cohesive energy on layer spacing $D$ in bigraphene is universal to all graphitic systems with evenly spaced layers. At spacings appropriate to intercalates, this differs from and begins to dominate the $C_4 D^{-4}$ power law for dispersion that has been widely used previously. The corrected power law (and a calculated $C_3$ coefficient) is then unsuccesfully employed in the semiempirical approach of [M. Hasegawa and K. Nishidate, Phys. Rev. B {\bf 70}, 205431 (2004)] (HN). A modified, physicially motivated semiempirical method including some $C_4 D^{-4}$ effects allows the HN method to be used successfully and gives an absolute increase of about $2-3$ to the predicted cohesive energy, while still maintaining the correct $C_3 D^{-3}$ asymptotics

"Drinking in the Dark" (DID): a simple mouse model of binge-like alcohol intake

One of the greatest challenges that scientists face when studying the neurobiology and/or genetics of alcohol (ethanol) consumption is that most preclinical animal models do not voluntarily consume enough ethanol to achieve pharmacologically meaningful blood ethanol concentrations (BECs). Recent rodent models have been developed that promote binge-like levels of ethanol consumption associated with high BECs (i.e., ≥100 mg/dl). This unit describes procedures for an animal model of binge-like ethanol drinking which has come to be called "drinking in the dark" (DID). The "basic" variation of DID involves replacing the water bottle with a bottle containing 20% ethanol for 2 to 4 hr, beginning 3 hr into the dark cycle, on cages of singly-housed C57BL/6J mice. Using this procedure, mice typically consume enough ethanol to achieve BECs >100 mg/dl and to exhibit behavioral evidence of intoxication. An alternative two-bottle (ethanol and water) procedure is also described

The Comparative Advantage of Firms

Multiproduct firms dominate production, and their product turnover contributes substantially to aggregate growth. Theories propose that multiproduct firms grow by diversifying into products which need the same know-how or capabilities, but are less clear on what these capabilities are. Input output tables show firms co-produce in industries that share intermediate inputs, suggesting input capabilities drive multiproduct production patterns. We provide evidence for this in Indian manufacturing: the similarity of a firm’s input mix to an industry’s input mix predicts entry into that industry. We identify the direction of causality from the removal of size-based entry barriers in input markets which made firms more likely to enter industries that were similar in input use to their initial input mix. We rationalize this finding with a model of industry choice and economies of scope to estimate the importance of input capabilities in determining comparative advantage. Complementarities driven by input capabilities make a firm on average 5% (and up to 15%) more likely to produce in an industry. Entry barriers in input markets constrained the comparative advantage of firms and were equivalent to a 10.5 percentage point tariff on inputs

Fate and Persistence of Crude Oil Stranded on a Sheltered Beach

Detailed observations, mapping and sampling were conducted following an experimental spill of 15 cu m of crude oil adjacent to the coast at Cape Hatt, Baffin Island, N.W.T. The beach could not retain all of the oil that reached the shoreline, and as a result, one-third of the spill oil was recovered in cleanup activities on the water, approximately one-third was lost to the atmosphere and to the ocean and one-third remained stranded on the intertidal zone. The stranded oil was subject to natural cleaning processes during approximately 6 months of open-water periods from 1981 to 1983. Over this period the surface area of oil cover was reduced by approximately half, whereas estimates indicate that 80% of the oil initially stranded (5.3 cu m) was removed. This natural removal of stranded oil occurred in a very sheltered environment. The reduction of the surface area and of the volume of oil resulted primarily from the physical processes associated with wave activity and ground-water leaching. By 1983 an asphalt pavement had developed in the upper intertidal zone on the beach-face slope. Total hydrocarbon concentrations of samples collected from the asphalt pavement indicated a significant increase in oil-in-sediment values in this zone to concentrations in the order of 2-5%. Oil removed from the beach was transported into the adjacent nearshore bottom sediments, where oil concentrations increased sixfold between 1981 and 1983. Physio-chemical weathering rates were relatively rapid immediately following the release of the oil, as the lower molecular weight (C1 to C10) hydrocarbons evaporated. Subsequent physio-chemical changes were heterogeneous .... The primary conclusion from the investigations undertaken to date is that oil is removed in substantial quantities from the intertidal zone even in such a sheltered, low-energy arctic environment. Similar changes should also be expected from comparable environments in lower latitudes.Key words: oil spill, natural oil weathering, asphalt pavement, beached oilMots clés: déversement de pétrole, dégradation naturelle du pétrole, plaque d’asphalte, pétrole échou&eacute

Population Genomics Reveals Seahorses (Hippocampus erectus) of the Western Mid-Atlantic Coast to Be Residents Rather than Vagrants

Understanding population structure and areas of demographic persistence and transients is critical for effective species management. However, direct observational evidence to address the geographic scale and delineation of ephemeral or persistent populations for many marine fishes is limited. The Lined seahorse (Hippocampus erectus) can be commonly found in three western Atlantic zoogeographic provinces, though inhabitants of the temperate northern Virginia Province are often considered tropical vagrants that only arrive during warm seasons from the southern provinces and perish as temperatures decline. Although genetics can locate regions of historical population persistence and isolation, previous evidence of Virginia Province persistence is only provisional due to limited genetic sampling (i.e., mitochondrial DNA and five nuclear loci). To test alternative hypotheses of historical persistence versus the ephemerality of a northern Virginia Province population we used a RADseq generated dataset consisting of 11,708 single nucleotide polymorphisms (SNP) sampled from individuals collected from the eastern Gulf of Mexico to Long Island, NY. Concordant results from genomic analyses all infer three genetically divergent subpopulations, and strongly support Virginia Province inhabitants as a genetically diverged and a historically persistent ancestral gene pool. These results suggest that individuals that emerge in coastal areas during the warm season can be considered “local” and supports offshore migration during the colder months. This research demonstrates how a large number of genes sampled across a geographical range can capture the diversity of coalescent histories (across loci) while inferring population history. Moreover, these results clearly demonstrate the utility of population genomic data to infer peripheral subpopulation persistence in difficult-to-observe species

Cross-reactivity among iodinated contrast agents: should we be concerned?

Background Although several papers deal with "cross-reactivity" in patients with iodinated contrast medium (ICM) hypersensitivity reactions (HSRs), there is no in-depth knowledge of this phenomenon. To define ICM-groups as potential reaction partners and to identify any potential clinical relevance in patients with ICM-HSRs. Methods The literature database PubMed was searched for eligible papers dealing with ICM-allergy and "cross-reactivity". The data presented by the papers was analyzed and individual patient data was extracted for re-evaluation based on a definition for both 'polyvalent reactivity' and 'cross-reactivity' as well as for chemical structure-dependent ICM-groups. Results Twenty-five original papers (with n=340 extracted patients) formed the study population. Incidences of polyvalent reactivity were non-significantly higher than incidences of cross-reactivity (both range from 0% to 100%). Crossover evaluation in reaction pairings (culprit ICM A with ICM B versus culprit ICM B with ICM A) showed concordance of only 30%. Data support rather non-cross-reactivity (individual reaction pattern) than cross-reactivity constellations. Conclusions The obtained results favour an individual reaction pattern, rather than a reactivity driven by chemical structures and so-called cross-reactivity

The Comparative Advantage of Firms

Multiproduct firms dominate production, and their product turnover contributes substantially to aggregate growth. Theories propose that multiproduct firms grow by diversifying into products which need the same know-how or capabilities, but are less clear on what these capabilities are. Input output tables show firms co-produce in industries that share intermediate inputs, suggesting input capabilities drive multiproduct production patterns. We provide evidence for this in Indian manufacturing: the similarity of a firm’s input mix to an industry’s input mix predicts entry into that industry. We identify the direction of causality from the removal of size-based entry barriers in input markets which made firms more likely to enter industries that were similar in input use to their initial input mix. We rationalize this finding with a model of industry choice and economies of scope to estimate the importance of input capabilities in determining comparative advantage. Complementarities driven by input capabilities make a firm on average 5% (and up to 15%) more likely to produce in an industry. Entry barriers in input markets constrained the comparative advantage of firms and were equivalent to a 10.5 percentage point tariff on inputs

The comparative advantage of firms

Multiproduct firms dominate production, and their product turnover contributes substantially to aggregate growth. Theories propose that multiproduct firms grow by diversifying into products which need the same know-how or capabilities, but are less clear on what these capabilities are. Input-output tables show firms coproduce in industries that share intermediate inputs, suggesting input capabilities drive multiproduct production patterns. We provide evidence for this in Indian manufacturing: the similarity of a firm's input mix to an industry's input mix predicts entry into that industry. We identify the direction of causality from the removal of size-based entry barriers in input markets which made firms more likely to enter industries that were similar in input use to their initial input mix. We rationalize this finding with a model of industry choice and economies of scope to estimate the importance of input capabilities in determining comparative advantage. Complementarities driven by input capabilities make a firm on average 5% (and up to 15%) more likely to produce in an industry. Entry barriers in input markets constrained the comparative advantage of firms and were equivalent to a 10.5 percentage point tariff on inputs