An Empirical Approach to Cosmological Galaxy Survey Simulation: Application to SPHEREx Low-Resolution Spectroscopy

Highly accurate models of the galaxy population over cosmological volumes are necessary in order to predict the performance of upcoming cosmological missions. We present a data-driven model of the galaxy population constrained by deep 0.1-8 $\rm \mu m$ imaging and spectroscopic data in the COSMOS survey, with the immediate goal of simulating the spectroscopic redshift performance of the proposed SPHEREx mission. SPHEREx will obtain over the full-sky $R\sim41$ spectrophotometry at moderate spatial resolution ($\sim6"$) over the wavelength range 0.75-4.18 $\rm \mu m$ and $R\sim135$ over the wavelength range 4.18-5 $\rm \mu m$. We show that our simulation accurately reproduces a range of known galaxy properties, encapsulating the full complexity of the galaxy population and enables realistic, full end-to-end simulations to predict mission performance. Finally, we discuss potential applications of the simulation framework to future cosmology missions and give a description of released data products

Forensic and psychiatric aspects of joint suicide with carbon monoxide

A case of joint suicide of a young woman and man who became acquainted in a suicide web forum and used this platform to make an appointment to commit suicide together is described. During their investigation, police were able to reconstruct the events by analysing the computer of the deceased women which was also found with the bodies. An indoor charcoal burning unit was used to release carbon monoxide as the method of suicid

Asymmetrical dynamics of voltage spread in retinal horizontal cell networks

This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.Lateral voltage spread in electrically coupled retinal horizontal cell networks is the substrate of center-surround antagonism in bipolar and ganglion cells. We studied its spatial and temporal properties in more detail in turtle L1 horizontal cells by using a contrast border as light stimulus. Experimental data were contrasted with expectations from a linear continuum model to specify the impact of nonlinearities. The assumptions for the diffusion term of the continuum model were justified by neurobiotin labeling. Measured voltage spread revealed two different length constants Λ+ and Λ0, under illuminated and nonilluminated regions of the retina, respectively, as predicted by the linear model. Length constants in the illuminated region showed strong temporal dynamics. For the initial phase of the horizontal cell responses Λ+ was larger than Λo. This was also in accordance with the model. Right at the peak of the response, however, Λ+ dropped below Λo and did not change any more. It is this temporal reversal of asymmetry in voltage spread and not the decrease of Λ+ itself that is lacked by the linear model. The observed independence of the mean ratio Λ+/Λo from light intensity in both the peak and the plateau phases of horizontal cell responses contradicts the linear assumption, too. These two effects have to be addressed to local nonlinearities in the horizontal cell network like a negative feedback loop from photoreceptors and/or voltage-dependent conductances. Due to the failure of the linear model, firm conclusions about the membrane resistance and the coupling resistance of the horizontal cell network cannot be drawn from length constant measurements.Peer Reviewe

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads to resistance in Streptococcus sanguis. To reveal this stalling mechanism we obtained 3.6-angstrom-resolution cryo-EM structures of ErmBL-stalled ribosomes with erythromycin. The nascent peptide adopts an unusual conformation with the C-terminal Asp10 side chain in a previously unseen rotated position. Together with molecular dynamics simulations, the structures indicate that peptide-bond formation is inhibited by displacement of the peptidyl-tRNA A76 ribose from its canonical position, and by non-productive interactions of the A-tRNA Lys11 side chain with the A-site crevice. These two effects combine to perturb peptide-bond formation by increasing the distance between the attacking Lys11 amine and the Asp10 carbonyl carbon. The interplay between drug, peptide and ribosome uncovered here also provides insight into the fundamental mechanism of peptide-bond formation

Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes

DNA oligonucleotides (ODN) applied to an organism are known to modulate the innate and adaptive immune system. Previous studies showed that a CpG-containing ODN (CpG-1-PTO) and interestingly, also a non-CpG-containing ODN (nCpG-5-PTO) suppress inflammatory markers in skin. In the present study it was investigated whether these molecules also influence cell apoptosis. Here we show that CpG-1-PTO, nCpG-5-PTO, and also natural DNA suppress the phosphorylation of PKB/Akt in a cell-type-specific manner. Interestingly, only epithelial cells of the skin (normal human keratinocytes, HaCaT and A-431) show a suppression of PKB/Akt. This suppressive effect depends from ODN lengths, sequence and backbone. Moreover, it was found that TGFα-induced levels of PKB/Akt and EGFR were suppressed by the ODN tested. We hypothesize that this suppression might facilitate programmed cell death. By testing this hypothesis we found an increase of apoptosis markers (caspase 3/7, 8, 9, cytosolic cytochrome c, histone associated DNA fragments, apoptotic bodies) when cells were treated with ODN in combination with low doses of staurosporin, a well-known pro-apoptotic stimulus. In summary the present data demonstrate DNA as a modulator of apoptosis which specifically targets skin epithelial cells

A description of the first open-source community release of MISTRA-v9.0: a 0D/1D atmospheric boundary layer chemistry model

We present MISTRA-v9.0, a one-dimensional (1D) and box (0D) atmospheric chemistry model. The model includes a detailed particle description with regards to the microphysics, gas–particle interactions, and liquid-phase chemistry within particles. Version 9.0 (v9.0) is the first release of MISTRA as an open-source community model. A major review of the code has been performed along with this public version release to improve the user friendliness and platform independence of the model. The purpose of this public release is to maximise the benefit of MISTRA to the community by making the model freely available and easier to use and develop. This paper presents a thorough description of the model characteristics and components. We show some examples of simulations reproducing previous studies with MISTRA, finding that v9.0 is consistent with previous versions

Science Impacts of the SPHEREx All-Sky Optical to Near-Infrared Spectral Survey: Report of a Community Workshop Examining Extragalactic, Galactic, Stellar and Planetary Science

SPHEREx is a proposed SMEX mission selected for Phase A. SPHEREx will carry out the first all-sky spectral survey and provide for every 6.2" pixel a spectra between 0.75 and 4.18 μm [with R∼41.4] and 4.18 and 5.00 μm [with R∼135]. The SPHEREx team has proposed three specific science investigations to be carried out with this unique data set: cosmic inflation, interstellar and circumstellar ices, and the extra-galactic background light. It is readily apparent, however, that many other questions in astrophysics and planetary sciences could be addressed with the SPHEREx data. The SPHEREx team convened a community workshop in February 2016, with the intent of enlisting the aid of a larger group of scientists in defining these questions. This paper summarizes the rich and varied menu of investigations that was laid out. It includes studies of the composition of main belt and Trojan/Greek asteroids; mapping the zodiacal light with unprecedented spatial and spectral resolution; identifying and studying very low-metallicity stars; improving stellar parameters in order to better characterize transiting exoplanets; studying aliphatic and aromatic carbon-bearing molecules in the interstellar medium; mapping star formation rates in nearby galaxies; determining the redshift of clusters of galaxies; identifying high redshift quasars over the full sky; and providing a NIR spectrum for most eROSITA X-ray sources. All of these investigations, and others not listed here, can be carried out with the nominal all-sky spectra to be produced by SPHEREx. In addition, the workshop defined enhanced data products and user tools which would facilitate some of these scientific studies. Finally, the workshop noted the high degrees of synergy between SPHEREx and a number of other current or forthcoming programs, including JWST, WFIRST, Euclid, GAIA, K2/Kepler, TESS, eROSITA and LSST

Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques

Atherosclerosis is a major cause of mortality and morbidity, which is mainly driven by complications such as myocardial infarction and stroke. These complications are caused by thrombotic arterial occlusion localized at the site of high-risk atherosclerotic plaques, of which early detection and therapeutic stabilization are urgently needed. Here we show that near-infrared autofluorescence is associated with the presence of intraplaque hemorrhage and heme degradation products, particularly bilirubin by using our recently created mouse model, which uniquely reflects plaque instability as seen in humans, and human carotid endarterectomy samples. Fluorescence emission computed tomography detecting near-infrared autofluorescence allows in vivo monitoring of intraplaque hemorrhage, establishing a preclinical technology to assess and monitor plaque instability and thereby test potential plaque-stabilizing drugs. We suggest that near-infrared autofluorescence imaging is a novel technology that allows identification of atherosclerotic plaques with intraplaque hemorrhage and ultimately holds promise for detection of high-risk plaques in patients

Semantic indeterminacy in object relative clauses

This article examined whether semantic indeterminacy plays a role in comprehension of complex structures such as object relative clauses. Study 1 used a gated sentence completion task to assess which alternative interpretations are dominant as the relative clause unfolds; Study 2 compared reading times in object relative clauses containing different animacy configurations to unambiguous passive controls; and Study 3 related completion data and reading data. The results showed that comprehension difficulty was modulated by animacy configuration and voice (active vs. passive). These differences were well correlated with the availability of alternative interpretations as the relative clause unfolds, as revealed by the completion data. In contrast to approaches arguing that comprehension difficulty stems from syntactic complexity, these results suggest that semantic indeterminacy is a major source of comprehension difficulty in object relative clauses. Results are consistent with constraint-based approaches to ambiguity resolution and bring new insights into previously identified sources of difficulty. (C) 2007 Elsevier Inc. All rights reserved