Factors predicting adequate lymph node yield in patients undergoing pancreatoduodenectomy for malignancy

BACKGROUND: Most pancreatoduodenectomy resections do not meet the minimum of 12 lymph nodes recommended by the American Joint Committee on Cancer for accurate staging of periampullary malignancies. The purpose of this study was to investigate factors affecting the likelihood of adequate nodal yield in pancreatoduodenectomy specimens subject to routine pathological assessment. METHODS: Six hundred sixty-two patients subject to pancreatoduodenectomy between 1990 and 2013 for pancreatic, ampullary, and common bile duct cancers were reviewed. Predictors of yielding at least 12 lymph nodes were evaluated with a logistic regression model, and a survival analysis was carried out to verify the prognostic implications of nodal counts. RESULTS: The median number of evaluated nodes was 17 (interquartile range 11 to 25), and less than 12 lymph nodes were reported in surgical specimens of 179 (27 %) patients. Tumor diameter ≥20 mm (odds ratio [OR] 2.547, 95 % confidence interval [CI] 1.225 to 5.329, P = 0.013), lymph node metastases (OR 2.642, 95 % CI 1.378 to 5.061, P = 0.004), and radical lymphadenectomy (OR 5.566, 95 % CI 2.041 to 15.148, P = 0.01) were significant predictors of retrieving 12 or more lymph nodes. Lymph node counts did not influence the overall prognosis of the patients. However, a subgroup analysis carried out for individual cancer sites demonstrated that removing at least 12 lymph nodes is associated with better prognosis for pancreatic cancer. CONCLUSIONS: Few variables affect adequate nodal yield in pancreatoduodenectomy specimens subject to routine pathological assessment. Considering the ambiguities related to the only modifiable factor identified, appropriate pathology training should be considered to increase nodal yield rather than more aggressive lymphatic dissection

Analysis of complications of laparoscopic management of abdominal diseases related to extended indications

Introduction: The introduction of minimally invasive procedures has changed the pattern of surgical complications.Some were only incidentally described in open surgery. Others significantly changed in character or incidence.Aim: We present the incidence, character and dynamics of important complications of laparoscopic procedures withinthe entire period of application of this technique.Material and methods: Patients operated on laparoscopically in the 2nd Department of General Surgery of theJagiellonian University between 1992 and 2009 (n = 8732) were included in the study. In order to follow the dynamicsof complication rates the study period was divided into 3 sub-periods: 1) 1992-1997, 2) 1998-2003, 3) 2004-2009.There were 2343 laparoscopic procedures performed in the 1st period, 3310 in the 2nd and 3079 in the 3rd.Results: The proportion of procedures other than cholecystectomy gradually increased: 1) –22.79%, 2) –31.81%,3) –40.05%. Overall conversion rate was 2.91%; in the 1st period it was 3.97%, in the 2nd 1.81%, and in the 3rd 3.28%.Complication-driven conversion rates were 0.60%, 0.27%, and 0.26%, respectively. Bleeding and biliary tree injurieswere the most common causes. Complications requiring reoperations occurred in 0.48% of patients, and theirincidence remained constant. Haemorrhage and intra-abdominal abscesses were observed most often. Use oflaparoscopic technique in their management increased in consecutive periods from 20% in the 1st, 45.83% in the 2nd,to 53.57% in the 3rd time period.Conclusions: The introduction of new advanced procedures did not increase overall complication rate. Change in theirnature and more common use of laparoscopic technique in their management were noted