Managing transition risk : toward an interdisciplinary understanding of strategies in the oil industry

How actors react to change is a crucial question for social scientists interested in global energy system transformation (EST). The global oil industry's response to the challenges associated with climate change and EST is a particular topic of discussion. Here, we argue for an interdisciplinary approach, bringing together insights from multiple disciplines within the social sciences that study oil companies, to further our understanding of what they are doing and why they are doing it. Although research on the political economy and socio-technical nature of EST has led to important insights, it tends to treat the global oil industry as a monolith with common interests and strategic objectives. We argue that the analytical and conceptual tools provided by the management and business literature can help unpack this ‘black box’. We explain how this is the case by exploring some of these tools and applying them to a novel heuristic, the ‘Transition Strategy Continuum’ that helps categorise and analyse the emerging strategies of the publicly-traded ‘International Oil Companies’ (IOCs). As such, we respond to the call for interdisciplinarity raised in the inaugural issue of this Journal. Ultimately, we want social scientists working on energy to take serious insights from other fields of inquiry that help illuminate the complexities of the task of transformation ahead for the IOCs and other related stakeholders

Supplementing glycosylation: A review of applying nucleotide-sugar precursors to growth medium to affect therapeutic recombinant protein glycoform distributions

The final publication is available at Elsevier via https://dx.doi.org/10.1016/j.biotechadv.2018.06.008 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/Glycosylation is a critical quality attribute (CQA) of many therapeutic proteins, particularly monoclonal antibodies (mAbs), and is a major consideration in the approval of biosimilar biologics due to its effects to therapeutic efficacy. Glycosylation generates a distribution of glycoforms, resulting in glycoproteins with inherent molecule-to-molecule heterogeneity, capable of activating (or failing to activate) different effector functions of the immune system. Glycoforms can be affected by the supplementation of nucleotide-sugar precursors, and related components, to culture growth medium, affecting the metabolism of glycosylation. These supplementations has been demonstrated to increase nucleotide-sugar intracellular pools, and impact glycoform distributions, but with varied results. These variations can be attributed to five key factors: Differences between cell platforms (enzyme/transporter expression levels); differences between recombinant proteins produced (glycan-site accessibility); the fermentation and sampling timeline (glucose availability and exoglycosidase accumulation); glutamine levels (affecting ammonia levels, which impact Golgi pH, as well as UDP-GlcNAc pools); and finally, a lack of standardized metrics for observing shifts in glycoform distributions (glycosylation indices) across different experiments. The purpose of this review is to provide detail and clarity on the state of the art of supplementation strategies for nucleotide-sugar precursors for affecting glycosylation in cell culture processes, and to apply glycosylation indices for standardized comparisons across the field.NSERC Strategic Network Grant [MabNet-NETGP 380070-08

New technical approach for the repair of an abdominal wall defect after a transverse rectus abdominis myocutaneous flap: a case report

<p>Abstract</p> <p>Introduction</p> <p>Breast reconstruction with autologous tissue transfer is now a standard operation, but abnormalities of the abdominal wall contour represent a complication which has led surgeons to invent techniques to minimize the morbidity of the donor site.</p> <p>Case presentation</p> <p>We report the case of a woman who had bilateral transverse rectus abdominis myocutaneous flap (TRAM-flap) breast reconstruction. The surgery led to the patient developing an enormous abdominal bulge that caused her disability in terms of abdominal wall and bowel function, pain and contour. In the absence of rectus muscle, the large defect was repaired using a combination of the abdominal wall component separation technique of Ramirez et al and additional mesh augmentation with a lightweight, large-pore polypropylene mesh (Ultrapro^®).</p> <p>Conclusion</p> <p>The procedure of Ramirez et al is helpful in achieving a tension-free closure of large defects in the anterior abdominal wall. The additional mesh augmentation allows reinforcement of the thinned lateral abdominal wall.</p

Rethinking energy geopolitics : towards a geopolitical economy of global energy transformation

We are in the midst of a global energy system transformation (GEST) which is rewiring the world economy, opening new axes of political contestation, and revolutionising the energetic basis of human civilisation. Energy geopolitics has not yet reconciled itself to this challenge. The field has traditionally been preoccupied with the dependence of Western states on cross-border flows of fossil fuels. More recently, efforts have been made to prospectively map out what the geopolitics of a fully renewable world might look like. What both literatures miss, however, is the very fact of the GEST: that we are living through a changing and contested process of global transformation, across interacting high- and low-emissions systems, whose contours are open and actively constructed over time. In this paper, we start to develop a provisional framework to make sense of the GEST, that is able to capture the full scale of the transformation, and its dynamic, contingent, constructed nature. We attend to three areas of geopolitical economy: the wide-ranging material dimensions of the transformation, its geographical space-making, and its conflict-ridden political economy. We then apply this framework to two case studies, one looking at the fraught role of fossil gas as a ‘transition fuel’, the other at lithium-ion batteries

Global energy scenarios : a geopolitical reality check

The ongoing Global Energy System Transformation (GEST) has attracted the attention of multiple academic disciplines and practitioners, approaching the process with different analytical and conceptual tools. We explore the ‘integration gap’ that exists between, on the one hand, Energy System Modelling and the stylised scenarios they use, and on the other, energy geopolitics. We consider how these approaches can complement each other to further our understanding of the global energy system’s future. Using a novel qualitative analytical framework, we review the extent to which a range of state-of-the-art global energy scenarios capture and reflect key issues in energy geopolitics in their narratives and model implementation. We find that few scenarios consider geopolitics in any depth. Those that do often treat it as a barrier to decarbonisation efforts that are aligned with the climate objectives of the Paris Agreement. Normative, Paris-aligned scenarios describe smooth processes of change where cooperation and coordination between countries are assumed and where geopolitics is often completely absent. Our findings emphasise the need for a more intricate understanding of the difference between ‘paper transitions’ and the real-world messiness and complexities of GEST, where geopolitics has a dual quality of simultaneously accelerating and hindering the transformation process

Global epidemiology of Neisseria gonorrhoeae in infertile populations: protocol for a systematic review.

INTRODUCTION: A key target of the WHO's 'Global Health Sector Strategy on sexually transmitted infections, 2016-2021' is achieving 90% reduction in Neisseria gonorrhoeae (gonorrhoea for short) incidence globally by 2030. Though untreated, gonorrhoea has been linked to infertility, the epidemiology of this infection in infertile populations remains poorly understood and somewhat a neglected area of reproductive health. Our proposed systematic review aims to fill this gap by characterising comprehensively gonorrhoea infection in infertile populations globally. METHODS AND ANALYSIS: All available studies of gonorrhoea infection in infertile populations, including infertility clinic attendees, will be systematically reviewed informed by Cochrane Collaboration guidelines. Findings will be reported following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data sources will be searched using broad index terms exploded to cover all subheadings and free text terms with no language or year restriction. Any epidemiological measure in infertile populations based on primary data will be eligible for inclusion. Measures based on different assay types will be extracted as separate studies for different analyses. Only one biospecimen type per assay type will be considered based on a predefined priority order. Samples including fewer than 10 participants or assessing infection in the upper genital tract will be excluded. Quality assessments will be conducted for all measures included in the review. Meta-analyses will be implemented using DerSimonian-Laird random effect models to estimate the mean prevalence of gonorrhoea in infertile populations globally, and stratified by WHO region, assay type, sex, infertility type, infertility diagnosis, among other factors. Detailed heterogeneity assessment will be performed, and potential sources of between-study heterogeneity will be explored using meta-regression. Review will be conducted from 26 March 2018 to 28 July 2019. ETHICS AND DISSEMINATION: An institutional review board clearance is not required as all data are publicly available. The findings will be disseminated through a peer-reviewed publication and international scientific meetings/workshops with key stakeholders. PROSPERO REGISTRATION NUMBER: CRD42018102934

adolescents and young adults with cancer care in asia the joint esmo siope siop asia survey

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