The nature of the high boiler degradation products from irradiated Santowax OMP

Based on the 1st author's M.S. thesis, Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1965"MIT-334-11."Includes bibliographical references (pages 89-92)Contract no. AT(38-1)-334M.I.T. DSR Project no. 981

Organic moderator-coolant in-pile irradiation loop for the MIT nuclear reactor : October 1, 1958 to October 1, 1959

Includes bibliographical references (leaf 34)First annual report; to October 1, 1958 to October 1, 1959Work performed under contract with Atomics International of North American Aviation, Inc. N9-S-514Division of Sponsored Research Project no. 8091Atomic Energy Commission contract no. AT(10-1)-106

Temozolomide is additive with cytotoxic effect of irradiation in canine glioma cell lines

Background: Similar to human glioblastoma patients, glial tumours in dogs have high treatment resistance and a guarded prognosis. In human medicine, the addition of temozolomide to radiotherapy leads to a favourable outcome in vivo as well as a higher antiproliferative effect on tumour cells in vitro. Objectives: The aim of the study was to determine the radio- and temozolomide-sensitivity of three canine glial tumour cell lines and to investigate a potential additive cytotoxic effect in combined treatment. Additionally, we wanted to detect the level of MGMT promoter methylation in these cell lines and to investigate a potential association between MGMT promoter methylation and treatment resistance. Methods: Cells were treated with various concentrations of temozolomide and/or irradiated with 4 and 8 Gy. Radiosensitization by temozolomide was evaluated using proliferation assay and clonogenic assay, and MGMT DNA methylation was investigated using bisulfite next-generation sequencing. Results: In all tested canine cell lines, clonogenicity was inhibited significantly in combined treatment compared to radiation alone. All canine glial cell lines tested in this study were found to have high methylation levels of MGMT promoter. Conclusions: Hence, an additive effect of combined treatment in MGMT negative canine glial tumour cell lines in vitro was detected. This motivates to further investigate the association between treatment resistance and MGMT, such as MGMT promoter methylation status

Radiopyrolysis

Statement of responsibility on title-page reads: E.A. Mason, T.H. Timmins, D.T. Morgan, and W.N. Bley"Issued: October 1966.""MIT-334-70 Reactor Technology."Also issued by T.H. Timmins and supervised by E.A. Mason as an Sc. D. thesis , Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1967Includes bibliographical references (pages A6.1-A6.7)MIT DSR Project no. 79819Work performed for the Savannah River Operations Office, U.S. Atomic Energy Commission under Contract no. AT(38-1)-33

Effect of reactor irradiation on Santowax OM and WR

Statement of responsibility on title page reads: E.A. Mason, M.L. Lee, S.T. Brewer, and W.N. Bley"Issued: June, 1968."Includes bibliographical referencesM.I.T. DSR Project no. 79819Work performed for the New York Operations Office, U. S. Atomic Energy Commission under contract No. AT(38-1)-33

Designing with Friction: Inverting Notions of Seamless Technology

There is growing unease and a sense within the design community of the value placed on efficient, simplified, and seamless interactions, with a growing awareness and documentation of their unintended consequences across society. By prioritizing ‘frictionless’ finance, healthcare, education products, and services, there has been a consorted effort to reduce or eliminate our daily frictions in the pursuit of efficiency and ease of use. The role of friction, however, is more nuanced than this, with a growing appreciation for designing with frictions: leveraging features usually considered problematic or exploring the benefits, barriers, and complexity beyond hindering users. In seeking a more balanced understanding of friction in systems design, this workshop will offer ways of bringing friction to the fore of design and examining its role across the domains of care, privacy, security, repairability, and autonomous vehicles. Participants will contribute to an exhibition of frictions before taking part in sessions that will unpack digital systems, identify frictions, and examine the ethical ambiguities posed by the addition or removal of friction in particular contexts. In employing the concept of friction as a critical and constructive design lens, we seek to develop further a Human-Computer Interaction (HCI) agenda for future discourse that inverts and provokes preconceptions and assumptions of a seamless digital landscape

In-pile loop irradiation studies of organic coolant materials : progress report, October 1, 1965 - December 31, 1965

"Issued: April 1, 1966.""AEC Research and Development Report"--Cover"MIT-334-48 ,Reactor Technology, Standard TID 4500."Includes bibliographical references (leaf 28)Progress report; October 1, 1965 - December 31, 1965M.I.T. project no. DSR 9819U.S. Atomic Energy Commission, Savannah River Operations Office contract no. AT(38-1)-33