Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum

Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitrobiological activity of four of the compounds on the Plasmodium falciparumchloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 /iM as the lowest inhibitory concentration

Dynamics of the attractive 1D Bose gas: analytical treatment from integrability

The physics of the attractive one-dimensional Bose gas (Lieb-Liniger model) is investigated with techniques based on the integrability of the system. Combining a knowledge of particle quasi-momenta to exponential precision in the system size with determinant representations of matrix elements of local operators coming from the Algebraic Bethe Ansatz, we obtain rather general analytical results for the zero-temperature dynamical correlation functions of the density and field operators. Our results thus provide quantitative predictions for possible future experiments in atomic gases or optical waveguides.Comment: 26 pages, 5 figure

Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH

Advances in light-sheet and confocal microscopy now allow imaging of cleared large biological tissue samples and enable the 3D appreciation of cell and protein localization in their native organ environment. However, the sample preparations for such imaging are often onerous, and their capability for antigen detection is limited. Here, we describe FLASH (fast light-microscopic analysis of antibody-stained whole organs), a simple, rapid, fully customizable technique for molecular phenotyping of intact tissue volumes. FLASH utilizes non-degradative epitope recovery and membrane solubilization to enable the detection of a multitude of membranous, cytoplasmic and nuclear antigens in whole mouse organs and embryos, human biopsies, organoids and Drosophila. Retrieval and immunolabeling of epithelial markers, an obstacle for previous clearing techniques, can be achieved with FLASH. Upon volumetric imaging, FLASH-processed samples preserve their architecture and integrity and can be paraffin-embedded for subsequent histopathological analysis. The technique can be performed by scientists trained in light microscopy and yields results in <1 week

Investigating corroboration of self-perceived posttraumatic growth among Sri Lankan Tamil survivors of ethnopolitical warfare through trait, domain, and profile agreement approaches.

Though research on assessing posttraumatic growth has been severely critiqued, some evidence suggests close others can observe and report changes in individuals following traumatic life events and are sensitive to idiosyncratic ways in which changes manifest. We extended these findings by investigating corroboration of self-perceived posttraumatic growth (PTG) and depreciation (PTD) as measured by the Posttraumatic Growth Inventory–42 (PTGI-42) among Sri Lankan Tamil war survivors (n = 200). Informants slightly corroborated overall levels of PTG and PTD, while a more nuanced profile analysis procedure revealed overall—but not distinctive—profile agreement. This suggests self–other agreement is modest and may partly reflect shared narratives and collective cultural understandings about how people change after trauma. Results demonstrate further that informants were not sensitive to idiosyncratic ways in which target individuals had changed. Together, the lack of validity evidence suggests that the PTGI-42 may be inadequate in some cross-cultural contexts as a measure of nuanced posttraumatic change (i.e., as a measure of specific changes in the five theorized domains of growth and depreciation). Future work should emphasize culture- and context-sensitive measurement of posttraumatic change, particularly focusing on methods other than retrospective self-reports, such as prospective longitudinal designs

Applied Personality Assessment: A 'Cronbachian' Perspective in Open Peer Commentary and Author's Response

Lievens's proposal that personality psychology would benefit from using applied tools of assessment—situation judgement tests and assessment centre exercises—was appropriate, especially as these tools focus on real-world criteria in high-stakes situations. Their use would help to integrate (specific) situationally influenced intra-individual differences (variability) and (general) inter-individual differences (diversity). Lievens's proposal also raised a broader issue: each assessment tool yields unique information, and together they have potential to provide a truly comprehensive model of personality based on the ‘Cronbachian’ perspective that has, so far, not been realized. Copyright © 2017 European Association of Personality Psycholog

Posttraumatic growth as positive personality change: evidence, controversies and future directions

This target article focuses on the construct of post-traumatic growth—positive psychological change experienced as a result of the struggle with highly challenging life circumstances. Prominent theories of post-traumatic growth define it in terms of personality change, and as a result, this area of research should be of great interest to personality psychologists. Despite this fact, most of the research on this topic has not been sufficiently informed by relevant research in personality psychology, and much of the extant research suffers from significant methodological limitations. We review the literature on post-traumatic growth, with a particular focus on how researchers have conceptualized it and the specific methodological issues associated with these conceptualizations. We outline some ways in which personality science can both be enriched by the study of this phenomenon and inform rigorous research on post-traumatic growth and provide a series of guidelines for future research of post-traumatic growth as positive personality change