253 research outputs found

    Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum

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    Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitrobiological activity of four of the compounds on the Plasmodium falciparumchloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 /iM as the lowest inhibitory concentration

    Investigating the veracity of self-reported post-traumatic growth: a profile analysis approach

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    Research into posttraumatic growth—positive psychological change that people report in their relationships, priorities in life, and self-perception after experiences of adversity—has been severely critiqued. We investigated the degree to which community members’ friends and relatives corroborated targets’ self-perceived positive and negative changes as measured by the Posttraumatic Growth Inventory-42. We found corroboration only for negative changes when we examined overall (averaged) scores. However, using a profile analysis procedure, we found significant participant–informant agreement on the domains of change that had relatively higher scores in the target’s profile and those that had relatively lower scores. Our results demonstrate that informants were able to observe that targets had changed and were sensitive to the idiosyncratic ways in which these changes had manifested in targets’ behavior

    The development of a light-weight, long-life diphacinone rodent bait

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    Ross, J.G., Eason, C.T., Sam, S., Shapiro, L., Blackie, H., MacMorran, D., Aylett, P., Tucker, N., Razzaq, H

    Dynamics of the attractive 1D Bose gas: analytical treatment from integrability

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    The physics of the attractive one-dimensional Bose gas (Lieb-Liniger model) is investigated with techniques based on the integrability of the system. Combining a knowledge of particle quasi-momenta to exponential precision in the system size with determinant representations of matrix elements of local operators coming from the Algebraic Bethe Ansatz, we obtain rather general analytical results for the zero-temperature dynamical correlation functions of the density and field operators. Our results thus provide quantitative predictions for possible future experiments in atomic gases or optical waveguides.Comment: 26 pages, 5 figure

    Enteric neurons increase maternal food intake during reproduction.

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    Reproduction induces increased food intake across females of many animal species1-4, providing a physiologically relevant paradigm for the exploration of appetite regulation. Here, by examining the diversity of enteric neurons in Drosophila melanogaster, we identify a key role for gut-innervating neurons with sex- and reproductive state-specific activity in sustaining the increased food intake of mothers during reproduction. Steroid and enteroendocrine hormones functionally remodel these neurons, which leads to the release of their neuropeptide onto the muscles of the crop-a stomach-like organ-after mating. Neuropeptide release changes the dynamics of crop enlargement, resulting in increased food intake, and preventing the post-mating remodelling of enteric neurons reduces both reproductive hyperphagia and reproductive fitness. The plasticity of enteric neurons is therefore key to reproductive success. Our findings provide a mechanism to attain the positive energy balance that sustains gestation, dysregulation of which could contribute to infertility or weight gain

    Self-related consequences of death fear and death denial

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    This study explores self-related outcomes (e.g., esteem, self-concept clarity, existential well-being) as a function of the interaction between self-reported levels of death fear and death denial. Consistent with the idea that positive existential growth can come from individuals facing, rather than denying, their mortality (Cozzolino, 2006), the authors observed that not fearing and denying death can bolster important positive components of the self. That is, individuals low in death denial and death fear evidenced an enhanced self that is valued, clearly conceived, efficacious, and that has meaning and purpose
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