Chronic Kidney Disease – Where Next? : Predicting Outcomes And Planning Care Pathways

Peer reviewedPublisher PD

Malaria: Existence Perpetuated by a Counterfeit Drug Industry

Malaria is a mosquito-borne disease that has plagued society for thousands of years. Malaria is often overlooked from the perspective of wealthier industrialized countries due to prevention efforts largely eliminating malaria from these locations. However, overlooking malaria’s continued global relevance is misinformed to the fact that nearly half the global population lives in regions at risk of malarial transmission. According to the CDC and WHO, such a high number of people at risk has subsequently led to an estimated 241 million cases and over 627 thousand deaths in 2020 alone. The purpose for the present research is to examine the continued prominence of malaria and highlight an often-ignored contributory factor to malaria’s perpetuated existence: the production of counterfeit antimalarial medications and treatments. This issue is a main contributor to the continued existence of malaria, a largely preventable disease. Manufacturer greed is at the heart of this industry and is further exacerbated by inadequate international regulations. A plethora of issues are the byproduct of this industry. Namely, perpetuated poverty levels, increased child morbidity and mortality rates, and the development of treatment-resistant strains of malaria. In order to prevent global ramifications from occurring, countries must see this industry as problematic to the world as a whole and not just to malaria endemic regions

A Research Agenda for Linked Closed Data

While it is preferable that Linked Data is published without access or licence restrictions, there will always remain certain datasets which, perhaps due to financial considerations, cannot be published as Linked Open Data. If these valuable datasets do join the Web of Linked Data, it will be as Linked Closed Data - Linked Data with access and license restrictions. In this paper, we outline a research agenda for Linked Closed Data that considers the effects that access and license restrictions may have on the Web of Linked Data. If implemented poorly, access restrictions have the potential to break URI resolvability, but even when implemented well, we can expect them to affect dataset selection processes and inter-dataset link creation rates. Additionally, there remains the technical challenge of developing and standardising access restriction and automated payment techniques for the Web of Linked Data

Long Term Prognosis after Acute Kidney Injury (AKI) - What is the Role of Baseline Kidney Function and Recovery? A Systematic Review

Peer reviewedPublisher PD

Consuming Linked Closed Data

The growth of the Linked Data corpus will eventually pre- vent all but the most determined of consumers from including every Linked Dataset in a single undertaking. In addition, we anticipate that the need for effective revenue models for Linked Data publishing will spur the rise of Linked Closed Data, where access to datasets is restricted. We argue that these impeding changes necessitate an overhaul of our current practices for consuming Linked Data. To this end, we propose a model for consuming Linked Data, built on the notion of continuous Information Quality assessment, which brings together a range of existing research and highlights a number of avenues for future work

Did She Mention My Name?: Citation of Academic Authority by the Supreme Court of Canada, 1985-1990

Readers of court judgments will have observed that in the course of expressing reasons for the decisions they reach, judges commonly refer to books and articles written by academics. This is not surprising. Many scholarly publications contain information, arguments and opinions pertinent to the choices that judges must make, and lawyers commonly refer to such works in the written and oral arguments they present to courts. We would therefore expect the judges who must assess and respond to such arguments to make mention of that scholarly material. Moreover a certain portion of academic writing-in particular, a preponderance of law review articles-is written as more or less direct exhortation tojudges about how to decide cases expected to come before them.1 Possibly this is no more than a rhetorical stance, for it may be that law professors are really writing to other law professors (or to no one), and that the practice of pretending to talk to appellate courts is simply a stylistic device which they ritualistically, perhaps unthinkingly, adopt. But presumably some portion of the writing that legal scholars ostensibly direct at judges is actually intended to be read by them and to influence the decisions they make. In any event, given the amount of writing couched as advice to judges, the amount of writing on legal matters generally, and lawyers\u27 practice of citing such material in argument, it comes as no shock to see that judges make reference to academic publications in their judgments

Arthroscopic transosseous rotator cuff repair: A prospective study on cost savings, surgical time, and outcomes

Objectives: Health expenditures in the United States are outpacing national income, and affordability has become a major policy issue. Over 500,000 rotator cuff repairs (RCR) are performed annually in the United States making RCR a potential source of cost savings. Arthroscopic trans-osseous equivalent (TOE) repair using a double row of anchors has shown superior biomechanical strength compared to other techniques, but at a higher cost. The arthroscopic transosseous (TO) repair is a novel technique allowing arthroscopic rotator cuff repair to be performed without suture anchors. Arthroscopic TO repair may be a means to provide similarly excellent patient outcomes while lowering the cost of care. The primary purpose is to compare the price differential and time of surgery for an arthroscopic rotator cuff repair using anchorless TO repair verses an anchor trans-osseous equivalent (TOE) repair. A secondary purpose of the study was to evaluate outcomes at 6 months postoperatively. Methods: A prospective, case-controlled study evaluating arthroscopic rotator cuff repair using two techniques was performed. The study group consisting of 21 patients undergoing TO repair was compared to a control group consisting of 22 patients undergoing TOE repair. The groups were controlled for size of tear, biceps treatment, acromioplasty, distal clavicle excision, and labral pathology. The primary outcome measures were surgical time as well as total cost of implants and equipment for each surgery, determined by an independent third party, Atlanticare Hospital. Secondary outcomes were changes in the SST, VAS, and SANE scores. Results: Mean total surgical implant/equipment cost per procedure for TOE repair was $2348.03 (SD 490.30) and for TO repair was$1204.97 (SD 330.69; p\u3c0.0001). Mean cut to close time for TOE repair was 85 minutes (95% CI is 77-90) verses 74 (95% CI = 71-98) for TO repair. A log rank test revealed no difference in time (p =0.95). A linear regression model was developed to evaluate the change in SST, VAS, and SANE scores from pre-op to 6 months follow-up. Our study was underpowered but no difference in outcome was observed. Conclusion: Arthroscopic TO rotator cuff repair is a cost savings and time neutral technique compared to TOE repair. A mean of $1100 can be saved in surgical cost per case. In a country that performs over 500,000 RCRs annually, utilizing a TO repair technique can provide substantial cost savings to the healthcare system. © The Author(s) 2015

Running away from the taskscape : ultramarathon as ‘dark ecology’

Drawing on reflections from a collaborative autoethnography, this article argues that ultramarathon running is defied by a 'dark' ecological sensibility (Morton 2007, 2010, 2016), characterised by moments of pain, disgust, and the macabre. In contrast to existing accounts, we problematise the notion that runners 'use' nature for escape and/or competition, while questioning the aesthetic-causal relationships often evinced within these accounts. With specific reference to the discursive, embodied, spatial and temporal aspects of the sport, we explore the way in which participants begin to appreciate the immense power of nature, while being humbled by the fragile and unstable foundations of human experience. Accordingly this article contributes novel insights into the human-nature complex that seek to move beyond Romantic analyses towards a more sophisticated understanding of the relationships between (nature) sport, people and place