Atopic dermatitis and ABO blood group

BACKGROUND: Atopic dermatitis is a chronic recurrent genetically determined skin disease affecting all age groups. PURPOSES: To study epidemiological and environmental factors, clinical patterns and the relationship of atopic dermatitis with ABO blood group system. METHODS: In 30 atopic dermatitis patients blood group distribution was compared with the distribution in 1500 relative donors of the blood bank of the same institute. FINDINGS: There were 18 males (60%) and 12 females (40%). Family and personal history of atopy were observed in 21 (70%(and 19 cases (63.3%) respectively. CONCLUSIONS: Blood group O subjects were significantly less in the study population in comparison to control. LIMITATION: Hospital based study with small sample size; hence the result cannot be generalized

MULTIPLE GENERALIZED XANTHOGRANULOMA IN ADULT: CASE REPORT AND TREATMENT

Xanthogranuloma is a benign, asymptomatic, and self-healing disorder of non-Langerhans cell histiocytosis, affecting mostly infants, children, and rarely adults. Diagnosis is easy in typical cases but become more complex in unusual forms. We report a case of a 28-year-old male patient who presented with multiple diffuse brown-to-yellowish papulonodular eruptions over extremities, ears, face, trunk, and extensors of joints with almost bilaterally symmetrical distribution for a period of one month. Histopathological examination of the skin biopsy specimen revealed features of xanthogranuloma. The patient was put on isotretinoin 20 mg once daily. Most of the lesions subsided or flattened within two months of isotretinoin therapy. This case is interesting because of the severity and atypical nature of the disease and also, the patient responded with isotretinoin therapy. But further study is required to observe the effectiveness of isotretinoin in xanthogranuloma