Modeling the cost effectiveness of injury interventions in lower and middle income countries: opportunities and challenges

BACKGROUND: This paper estimates the cost-effectiveness of five interventions that could counter injuries in lower and middle income countries(LMICs): better traffic enforcement, erecting speed bumps, promoting helmets for bicycles, promoting helmets for motorcycles, and storing kerosene in child proof containers. METHODS: We adopt an ingredients based approach to form models of what each intervention would cost in 6 world regions over a 10 year period discounted at both 3% and 6% from both the governmental and societal perspectives. Costs are expressed in local currency converted into US $2001. Each of these interventions has been assessed for effectiveness in a LMIC in limited region, these effectiveness estimates have been used to form models of disability adjusted life years (DALYs) averted for various regions, taking account of regional differences in the baseline burden of injury. RESULTS: The interventions modeled in this paper have cost effectiveness ratios ranging from US$5 to $556 per DALY averted depending on region. Depending on local acceptability thresholds many of them could be judged cost-effective relative to interventions that are already adopted. Enhanced enforcement of traffic regulations is the most cost-effective interventions with an average cost per DALY of$64 CONCLUSION: Injury counter measures appear to be cost-effective based on models. More evaluations of real interventions will help to strengthen the evidence basis

Analyses of \u3ci\u3eD\u3c/i\u3e\u3csup\u3e+\u3c/sup\u3e→\u3ci\u3eK\u3c/i\u3e\u3csub\u3e\u3ci\u3eS\u3c/i\u3e\u3c/sub\u3e\u3csup\u3e0\u3c/sup\u3e\u3ci\u3eK\u3c/i\u3e\u3csup\u3e+\u3c/sup\u3e and \u3ci\u3eD\u3c/i\u3e\u3csup\u3e+\u3c/sup\u3e → \u3ci\u3eK\u3c/i\u3e\u3csub\u3e\u3ci\u3eS\u3c/i\u3e\u3c/sub\u3e\u3csup\u3e0\u3c/sup\u3eπ\u3csup\u3e+\u3c/sup\u3e

Using data collected with the CLEO II detector at the Cornell Electron Storage Ring, we present new measurements of the branching fractions for D+→KSK+and D+ → KSπ+ . These results are combined with other CLEO measurements to extract the ratios of isospin amplitudes and phase shifts for D → KK and D → K π

Status of the US Long Baseline Neutrino Experiment Study

The US Long Baseline Neutrino Experiment Study was commissioned jointly by Brookhaven National Laboratory and Fermi National Accelerator Laboratory to investigate the potential for future U.S. based long baseline neutrino oscillation experiments beyond the currently planned program. The Study focused on MW class convention at neutrino beams that can be produced at Fermilab or BNL. The experimental baselines are based on two possible detector locations: (1) off-axis to the existing Fermilab NuMI beamline at baselines of 700 to 810 km and (2) NSF's proposed future Deep Underground Science and Engineering Laboratory (DUSEL) at baselines greater than 1000 km. Two detector technologies are considered: a megaton class Water Cherenkov detector deployed deep underground at a DUSEL site, or a 100kT Liquid Argon Time-Projection Chamber (TPC) deployed on the surface at any of the proposed sites. The physics sensitivities of the proposed experiments are summarized. We find that conventional horn focused wide-band neutrino beam options from Fermilab or BNL aimed at a massive detector with a baseline of > 1000 km have the best sensitivity to CP violation and the neutrino mass hierarchy for values of the mixing angle {theta}{sub 13} down to 2.2{sup o}

The US Long Baseline Neutrino Experiment Study

The US Long Baseline Neutrino Experiment Study was commissioned jointly by Brookhaven National Laboratory (BNL)and Fermi National Accelerator Laboratory (FNAL) to investigate the potential for future U.S. based long baseline neutrino oscillation experiments using MW class conventional neutrino beams that can be produced at FNAL. The experimental baselines are based on two possible detector locations: (1) off-axis to the existing FNAL NuMI beamline at baselines of 700 to 810 km and (2) NSF's proposed future Deep Underground Science and Engineering Laboratory (DUSEL) at baselines greater than 1000km. Two detector technologies are considered: a megaton class Water Cherenkov detector deployed deep underground at a DUSEL site, or a 100kT Liquid Argon Time-Projection Chamber (TPC) deployed on the surface at any of the proposed sites. The physics sensitivities of the proposed experiments are summarized. We find that conventional horn focused wide-band neutrino beam options from FNAL aimed at a massive detector with a baseline of > 1000km have the best sensitivity to CP violation and the neutrino mass hierarchy for values of the mixing angle {theta}{sub 13} down to 2{sup o}

Search for the decay B→D_(s1)^+ (2536)X

We have searched for the decay B⃗D_(s1)^+(2536)X and measured an upper limit for the inclusive branching fraction of B(B⃗D_(s1)^+X)<0.96% at the 90% confidence level. This limit is small compared with the total expected B⃗D^((*))D^((*))KX rate. Assuming factorization, the D_(s1)^+ decay constant is constrained to be fD_(s1)^+<114 MeV at the 90% confidence level, at least 2.5 times smaller than that of D_s^+

Selection rules in three-body B decay from factorization

Extending the dynamics underlying the factorization calculation of two-body decays, we propose simple selection rules for nonresonant three-body B decays. We predict, for instance, that in the Dalitz plot of B^0-->D^0-bar\pi^+\pi^-, practically no events should be found in the corner of E(\pi^+) < \Lambda_{QCD} as compared with the corner of E(\pi^-) < \Lambda_{QCD}. We also predict that there should be very few three-body decay events with a soft meson resonance and two energetic mesons or meson resonances. The selection rules are quite different from the soft pion theorem, since they apply to different kinematical regions. For B^0 -->D^0-bar\pi^+\pi^-, the latter predicts that the decay matrix element vanishes in the zero-four-momentum limit of \pi^+ instead of \pi^-. Since this marked difference from the soft pion theorem is directly related to the issue of short-distance QCD dominance in the FSI of two-body B decays, experimental test of the selection rules will shed light on strong interaction dynamics of B decay.Comment: 12 pages in REVTEX including 3 eps figure