203 research outputs found
The BAHAMAS project: the CMB--large-scale structure tension and the roles of massive neutrinos and galaxy formation
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Recent studies have presented evidence for tension between the constraints on Omega_m and sigma_8 from the cosmic microwave background (CMB) and measurements of large-scale structure (LSS). This tension can potentially be resolved by appealing to extensions of the standard model of cosmology and/or untreated systematic errors in the modelling of LSS, of which baryonic physics has been frequently suggested. We revisit this tension using, for the first time, carefully-calibrated cosmological hydrodynamical simulations, which thus capture the back reaction of the baryons on the total matter distribution. We have extended the BAHAMAS simulations to include a treatment of massive neutrinos, which currently represents the best motivated extension to the standard model. We make synthetic thermal Sunyaev-Zel'dovich effect, weak galaxy lensing, and CMB lensing maps and compare to observed auto- and cross-power spectra from a wide range of recent observational surveys. We conclude that: i) in general there is tension between the primary CMB and LSS when adopting the standard model with minimal neutrino mass; ii) after calibrating feedback processes to match the gas fractions of clusters, the remaining uncertainties in the baryonic physics modelling are insufficient to reconcile this tension; and iii) invoking a non-minimal neutrino mass, typically of 0.2-0.4 eV (depending on the priors on the other relevant cosmological parameters and the datasets being modelled), can resolve the tension. This solution is fully consistent with separate constraints on the summed neutrino mass from the primary CMB and baryon acoustic oscillations, given the internal tensions in the Planck primary CMB dataset
From RNAi Screens to Molecular Function in Embryonic Stem Cells
- Author
- A Henschel
- A Reynolds
- AC Gingras
- AL Jackson
- AL Jackson
- AL Jackson
- AW Bird
- B Xuan
- BD Parsons
- C Buecker
- C Tong
- D Szklarczyk
- D Yang
- F Calegari
- FA Habermann
- Frank Buchholz
- G Hu
- G Keller
- GB Udy
- GJ Hannon
- H Amano
- H Niwa
- H Riele te
- I Chambers
- I Poser
- IG Brons
- Ina Poser
- J Kim
- J Silva
- JA Thomson
- JP Muyrers
- JR Hutchins
- JW Myers
- JW Myers
- JZ Zhang
- K Okita
- K Takahashi
- L Ding
- L Ding
- Li Ding
- M Pritsker
- M Sarov
- Maciej Paszkowski-Rogacz
- MJ Evans
- N Ivanova
- NY Chia
- P Lassus
- PJ Tesar
- QL Ying
- QL Ying
- R Abujarour
- R Jian
- R Kittler
- R Kittler
- R Kittler
- S Lubitz
- S Mohr
- SM Elbashir
- T Kocher
- TG Fazzio
- Y Yoshida
- Y Zhang
- Publication venue
- Humana Press Inc
- Publication date
- 01/01/2011
- Field of study
The ability of embryonic stem (ES) cells to generate any of the around 220 cell types of the adult body has fascinated scientists ever since their discovery. The capacity to re-program fully differentiated cells into induced pluripotent stem (iPS) cells has further stimulated the interest in ES cell research. Fueled by this interest, intense research has provided new insights into the biology of ES cells in the recent past. The development of large-scale and high throughput RNAi technologies has made it possible to sample the role of every gene in maintaining ES cell identity. Here, we review the RNAi screens performed in ES cells to date and discuss the challenges associated with these large-scale experiments. Furthermore, we provide a perspective on how to streamline the molecular characterization following the initial phenotypic description utilizing bacterial artificial chromosome (BAC) transgenesis
Kinematics of the Southern Rhodope Core Complex (North Greece)
- Author
- A Harkovska
- A Kilias
- A Kilias
- A Kokkinakis
- A Kounov
- A Liati
- A Liati
- A Liati
- A Liati
- A Liati
- A Liati
- A Marakis
- A Moro Del
- B Wernicke
- B Wernicke
- BC Burchfiel
- C Kissel
- C Kolocotroni
- C Tirel
- CB Papazachos
- CB Papazachos
- D Berthé
- D Gapais
- D Kondopoulou
- D Sokoutis
- DA Dinter
- DA Dinter
- DA Dinter
- Dimitrios Sokoutis
- E Hejl
- ED Mposkos
- F Kockel
- G Ranalli
- GS Lister
- H Haubold
- IG Paishin
- J Dixon
- J Driessche Van Den
- J Mascle
- J Wakabayashi
- J-P Brun
- Jean-Pierre Brun
- JP Burg
- JP Burg
- L Block
- L Jolivet
- L Lee
- LE Ricou
- LJ Sonder
- MD Crittenden
- N Lalechos
- N Lyberis
- N Wawrzenitz
- P Bird
- P Gautier
- P Gautier
- P Gautier
- P Gautier
- P Gautier
- P Kronberg
- P Turpaud
- RD Hyndman
- S Dimitriadis
- S Dimitriadis
- T Reischmann
- TV Gerya
- W Harre
- W Meyer
- WR Buck
- X Le Pichon
- Publication venue
- Publication date
- 01/01/2007
- Field of study
The Southern Rhodope Core Complex is a wide metamorphic dome exhumed in the northern Aegean as a result of large-scale extension
from mid-Eocene to mid-Miocene times. Its roughly triangular shape is bordered on the SW by the Jurassic and Cretaceous metamorphic
units of the Serbo-Macedonian in the Chalkidiki peninsula and on the N by the eclogite bearing gneisses of the Sideroneron
massif. The main foliation of metamorphic rocks is flat lying up to 100 km core complex width. Most rocks display a stretching
lineation trending NEâ SW. The Kerdylion detachment zone located at the SW controlled the exhumation of the core complex from
middle Eocene to mid-Oligocene. From late Oligocene to mid-Miocene exhumation is located inside the dome and is accompanied
by the emplacement of the synkinematic plutons of Vrondou and Symvolon. Since late Miocene times, extensional basin sediments
are deposited on top of the exhumed metamorphic and plutonic rocks and controlled by steep normal faults and flat-ramp-type
structures. Evidence from Thassos Island is used to illustrate the sequence of deformation from stacking by thrusting of the
metamorphic pile to ductile extension and finally to development of extensional Plio-Pleistocene sedimentary basin. Paleomagnetic
data indicate that the core complex exhumation is controlled by a 30� dextral rotation of the Chalkidiki block. Extensional
displacements are restored using a pole of rotation deduced from the curvature of stretching lineation trends at core complex
scale. It is argued that the Rhodope Core Complex has recorded at least 120 km of extension in the North Aegean, since the
last 40 My
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
- Author
- Abrignani S
- Adams D
- Altucci L
- Amin V
- Amit I
- Antonarakis SE
- Aparicio S
- Arima T
- Arrigoni L
- Arts R
- Asnafi V
- Badosa ME
- Bae JB
- Bassler K
- Beck S
- Berkman B
- Bernstein BE
- Bilenky M
- Bird A
- Bock C
- Boehm B
- Bourque G
- Breeze CE
- Brors B
- Bujold D
- Burren O
- Bussemakers MJ
- Butterworth A
- Campo E
- Carrillo-de-Santa-Pau E
- Chadwick L
- Chan KM
- Chen W
- Cheung TH
- Chiapperino L
- Choi NH
- Chung HR
- Clarke L
- Connors JM
- Cronet P
- Danesh J
- de Almeida M
- Dermitzakis M
- Drewes G
- Durek P
- Dyke S
- Dylag T
- Eaves CJ
- Ebert P
- Eils J
- Eils R
- Ennis CA
- Enver T
- Feingold EA
- Felder B
- Ferguson-Smith A
- Fitzgibbon J
- Flicek P
- Foo RSY
- Fraser P
- Frontini M
- Furlong E
- Gakkhar S
- Gasparoni G
- Gasparoni N
- Geschwind DH
- Glažar P
- Graf T
- Grosveld F
- Guan XY
- Guigo R
- Gut IG
- Hamann A
- Han BG
- Harris RA
- Heath S
- Helin K
- Hengstler JG
- Heravi-Moussavi A
- Herrup K
- Hill S
- Hilton JA
- Hitz BC
- Horsthemke B
- Hu M
- Hwang JY
- Ip NY
- Ito T
- Javierre BM
- Jenko S
- Jenuwein T
- Joly Y
- Jones SJM
- Kanai Y
- Kang HG
- Karsan A
- Kiemer AK
- Kim SC
- Stunnenberg HG
- Publication venue
- Publication date
- 17/11/2016
- Field of study
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal at http://www.cell.com/consortium/IHEC) highlight the coordinated achievements of IHEC teams to gather and interpret comprehensive epigenomic datasets to gain insights in the epigenetic control of cell states relevant for human health and disease
Establishment of epigenetic patterns in development
- Author
- A Bird
- A Kohlmaier
- A Meissner
- A Nagy
- A Ralston
- A Tsumura
- AC Ferguson-Smith
- Anton Wutz
- AP Bracken
- B Schuettengruber
- BD Fodor
- C Beisel
- C Chazaud
- CS Nabel
- D Landeira
- D O'Carroll
- D Pasini
- D Pullirsch
- E Li
- E Li
- F Fuks
- F Lienert
- F Lohmann
- F Mohn
- G Csankovszki
- G Ficz
- G Guo
- G Li
- H Niwa
- H Sasaki
- H Wu
- HM Herz
- IG Brons
- IJ Majewski
- J Nichols
- J Rossant
- J Sharif
- J Silva
- J Wang
- JC Peng
- JC Scheuermann
- JE Dodge
- JK Stock
- JL Rinn
- JW Voncken
- K Blair
- K Iqbal
- K Kaji
- K Kaji
- K Plath
- K Williams
- LA Boyer
- LS Yeap
- M Bostick
- M Guttman
- M Hemberger
- M Ku
- M Leeb
- M Leeb
- M Leeb
- M Napoles de
- M Okano
- M Pawlak
- M Sakaue
- M Tachibana
- M Tahiliani
- M Tan
- Martin Leeb
- ME Blewitt
- MM Dawlaty
- O Yildirim
- P Yuan
- PJ Tesar
- R Eskeland
- RK Ng
- S Augui
- S Erhardt
- S Ito
- S Schoeftner
- S Seenundun
- S Shaver
- S Yamanaka
- SH Orkin
- SJ Arnold
- SJ Chamberlain
- SS Gehani
- T Graf
- T Hamatani
- T Kunath
- T Sado
- TP Gu
- TS Mikkelsen
- U Elling
- W Mak
- WA Pastor
- WT Poueymirou
- X Shen
- Y Marahrens
- YF He
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2012
- Field of study
The distinct cell types of the body are established from the fertilized egg in development and assembled into functional tissues. Functional characteristics and gene expression patterns are then faithfully maintained in somatic cell lineages over a lifetime. On the molecular level, transcription factors initiate lineage-specific gene expression programmmes and epigenetic regulation contributes to stabilization of expression patterns. Epigenetic mechanisms are essential for maintaining stable cell identities and their disruption can lead to disease or cellular transformation. Here, we discuss the role of epigenetic regulation in the early mouse embryo, which presents a relatively well-understood system. A number of studies have contributed to the understanding of the function of Polycomb group complexes and the DNA methylation system. The role of many other chromatin regulators in development remains largely unexplored. Albeit the current picture remains incomplete, the view emerges that multiple epigenetic mechanisms cooperate for repressing critical developmental regulators. Some chromatin modifications appear to act in parallel and others might repress the same gene at a different stage of cell differentiation. Studies in pluripotent mouse embryonic stem cells show that epigenetic mechanisms function to repress lineage specific gene expression and prevent extraembryonic differentiation. Insights into this epigenetic “memory” of the first lineage decisions help to provide a better understanding of the function of epigenetic regulation in adult stem cell differentiation
Spin asymmetries A1 and structure functions g1 of the proton and the deuteron from polarized high energy muon scattering.
- Author
- Adeva B
- Akdogan T
- Arik E
- Arvidson A
- Badelek B
- Bardin G
- Baum Günter
- Berglund P
- Betev L
- Bird IG
- Birsa R
- Bjorkholm P
- Boutemeur M
- Bradamante F
- Bravar A
- Bressan A
- Bultmann S
- Burtin E
- Cavata C
- Crabb D
- Cranshaw J
- Cuhadar T
- Dalla Torre S
- de Botton N
- de Groot N
- de Lesquen A
- Derro B
- Deshpande A
- Dhawan S
- Dulya C
- Dyring A
- Eichblatt S
- Faivre JC
- Fasching D
- Feinstein F
- Fernandez C
- Forthmann S
- Frois B
- Gallas A
- Garzon JA
- Gilly H
- Giorgi M
- Goertz S
- Golutvin IA
- Gracia G
- Haft K
- Hasegawa T
- Hautle P
- Hayashi N
- Heusch CA
- Horikawa N
- Hughes VW
- Igo G
- Ishimoto S
- Iwata T
- Kabuss EM
- Kageya T
- Karev A
- Kessler HJ
- Ketel TJ
- Kiryluk J
- Kiryushin I
- Kishi A
- Kisselev Y
- Klostermann L
- Kramer D
- Krivokhijine V
- Kroger W
- Kukhtin V
- Kurek K
- Kyynarainen J
- Lamanna M
- Landgraf U
- Le Goff JM
- Lehar F
- Lichtenstadt J
- Lindqvist T
- Litmaath N
- Lowe M
- Magnon A
- Mallot GK
- Marie F
- Martin A
- Martino J
- Matsuda T
- Mayes B
- McCarthy JS
- Medved K
- Meyer W
- Miller David
- Miyachi Y
- Mori K
- Moromisato J
- Nagaitsev A
- Nassalski J
- Naumann L
- Niinikoski TO
- Oberski JEJ
- Ogawa A
- Ozben C
- Perdekamp MG
- Pereira H
- Perrot-Kunne F
- Peshekhonov D
- Piegia R
- Pinsky L
- Platchkov S
- Plo M
- Pose D
- Postma H
- Pretz J
- Puntaferro R
- Pussieux T
- Radel G
- Reicherz G
- Rijllart A
- Roberts J
- Rock S
- Rodriguez M
- Rondio E
- Ropelewski L
- Sabo I
- Saborido J
- Sandacz A
- Savin I
- Schiavon P
- Schiller A
- Schuler KP
- Seitz R
- Semertzidis Y
- Sergeev S
- Shanahan P
- Sichtermann EP
- Simeoni F
- Smirnov GI
- Staude A
- Steinmetz A
- Stiegler U
- Stuhrmann H
- Szleper M
- Tessarotto F
- Thers D
- Tlaczala W
- Tripet A
- Unel G
- van Dantzig R
- van Middelkoop G
- Velasco M
- Vogt J
- von Goeler E
- von Harrach D
- Voss R
- Whitten C
- Willumeit R
- Windmolders R
- Wislicki W
- Witzmann A
- Ylostalo J
- Zamiatin NI
- Zanetti AM
- Zaremba K
- Zhao J
- Publication venue
- Publication date
- 01/01/1998
- Field of study
Adeva B, Akdogan T, Arik E, et al. Spin asymmetries A(1) and structure functions g(1) of the proton and the deuteron from polarized high energy muon scattering. Phys.Rev. D. 1998;58(11): 112001.We present the final results of the spin asymmetries A(1) and the spin structure functions g(1) of the proton and the deuteron in the kinematic range 0.0008 < x < 0.7 and 0.2 < Q(2) < 100 GeV2. For the determination of A(1), in addition to the usual method which employs inclusive scattering events and includes a large radiative background at low x, we use a new method which minimizes the radiative background by selecting events with at least one hadron as well as a muon in the final state. We find that this hadron method gives smaller errors for x < 0.02, so it is combined with the usual method to provide the optimal set of results. [S0556-2821(98)07017-9]
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
- Author
- Aanensen DM
- Abudahab K
- Adams A
- Adams H
- Adeniji K
- Afifi S
- Aggarwal D
- Agranoff D
- Agwuh K
- Ahmad SSY
- Ahmed KA
- Aigrain L
- Ail D
- Alcolea-Medina A
- Aldera EL
- Alegria A
- Alex B
- Alikhan N-F
- Allara E
- Allen S
- Amato R
- Andrikopoulos P
- Angus B
- Angyal A
- Annett T
- Aplin S
- Ariani CV
- Armstrong JA
- Asad H
- Ash A
- Ashfield P
- Ashford F
- Ashish A
- Ashworth M
- Asiimwe IG
- Atkinson D
- Atkinson L
- Attwood SW
- Auckland C
- Aydin A
- Bach B
- Baillie JK
- Baker DJ
- Baker P
- Bakshi S
- Balcazar CE
- Ball J
- Barclay WS
- Bari S
- Barlow G
- Barlow SL
- Barnass S
- Barrett JC
- Barrett N
- Barrow M
- Barton E
- Bashton M
- Bassett AR
- Bassford C
- Basude S
- Batra R
- Baxter C
- Baxter D
- Bayzid N
- Beadsworth M
- Beaver C
- Beckett AH
- Beckwith SM
- Bedford L
- Beer R
- Beggs A
- Bellis KL
- Bernatoniene J
- Berridge J
- Berry C
- Berry L
- Bertolusso B
- Best A
- Best N
- Betteridge E
- Bibby D
- Bicknell K
- Binns D
- Birchley A
- Bird PW
- Bishop C
- Blacow R
- Blakey V
- Blane B
- Bogaert D
- Bolt F
- Bonfield J
- Bonner S
- Bonsall D
- Booth L
- Boswell T
- Bosworth A
- Bothma P
- Bourgeois Y
- Boyd O
- Bradley DT
- Breen C
- Brennan B
- Bresner C
- Breuer J
- Bridgett S
- Brittain-Long R
- Bronner IF
- Brooks E
- Broos A
- Brown JR
- Brown R
- Bucca G
- Buchan SL
- Buck D
- Bull M
- Bullock K
- Bulteel N
- Burden T
- Burns PJ
- Burtenshaw A
- Burton-Fanning S
- Byaruhanga T
- Byott M
- Campbell S
- Carabelli AM
- Cargill JS
- Carlile M
- Carlucci N
- Carracedo AD
- Carson G
- Caruth V
- Carvalho SF
- Casey A
- Cass E
- Castigador A
- Catalan J
- Catterall BWA
- Chadwick D
- Chadwick D
- Chalker V
- Chaloner NJ
- Chambler D
- Chand M
- Chand M
- Chappell JG
- Charalampous T
- Chatterton W
- Chaudhry Y
- Chechi K
- Chee N
- Child J
- Chukkambotla S
- Churcher CM
- Clark G
- Clark JJ
- Clark T
- Clarke EA
- Clarke P
- Clohisey S
- Cogger BJ
- Cole K
- Cole S
- Cole S
- Collini P
- Collins J
- Colquhoun R
- Connor M
- Connor TR
- Cook KF
- Cooke GS
- Coombes J
- Cooper L
- Corden S
- Cormie C
- Correia GDS
- Cortes N
- Cosgrove C
- Cotic M
- Cotton S
- Cottrell S
- Coupland L
- Cox A
- Cox H
- Cox M
- Craine N
- Crawford L
- Cross A
- Crown MR
- Crudgington D
- Cumley N
- Cupitt J
- Curran MD
- Curran T
- Cutino-Moguel M-T
- da Silva Filipe A
- da Silva Filipe A
- Dabrera G
- Dalton J
- Darby AC
- Dark P
- Davidson RK
- Davies A
- Davies RM
- Davis C
- Davis T
- Dawson C
- de Angelis D
- De Lacy E
- de Oliveira Martins L
- de Silva TI
- Debebe J
- Denton-Smith R
- Dervisevic S
- Dervisevic S
- Dewar R
- Dey J
- Dias J
- Dincarslan O
- Dobie D
- Docherty AB
- Donegan C
- Dong D
- Dong T
- Donnison P
- Donohue C
- Dorman MJ
- Douthwaite S
- Downing F
- Driscoll M
- Drummond A
- du Plessis L
- Duckworth N
- Dumas M-E
- Dunachie S
- Dunn C
- Dunning J
- DuRand I
- Durham J
- Dushianthan A
- Dyer P
- Dyer T
- Eastick K
- Easton LJ
- Eccles R
- Edgeworth J
- Edwards S
- El Bouzidi K
- Eldirdiri S
- Ellaby N
- Elliott A
- Elliott S
- Eltringham G
- Ensell L
- Erkiert MJ
- Essex S
- Evans A
- Evans C
- Evans C
- Evans JM
- Everson W
- Eziefula C
- Fairley DJ
- Fallon K
- Fanaie A
- Farr BW
- Fearn C
- Fegan C
- Feltwell T
- Ferguson L
- Fina L
- Finch L
- Finn A
- Fisher LWS
- Flaherty L
- Flaviani F
- Fleming VM
- Fletcher T
- Forrest S
- Foster T
- Foster-Nyarko E
- Foulkes BH
- Foulser L
- Fragakis M
- Frampton D
- Francois S
- Fraser C
- Freeman TM
- Fryer H
- Fuchs M
- Fuller W
- Fullerton D
- Gajee K
- Galai K
- Gallagher A
- Gallagher E
- Gallagher MD
- Gallis M
- Gamble C
- Garcia-Dorival I
- Garg A
- Garg S
- Garg S
- Gaskin A
- Gatica-Wilcox B
- Geidelberg L
- Gemmell M
- Georgana I
- George RP
- Gifford L
- Gilbert L
- Girgis ST
- Girvan M
- Gkrania-Klotsas E
- Glaysher S
- Godden J
- Goldsmith A
- Goldstein EJ
- Golubchik T
- Gomes AN
- Gonçalves S
- Goodfellow IG
- Goodwin S
- Goudarzi S
- Gourtovaia M
- Graham C
- Graham C
- Graham L
- Grant PR
- Green A
- Green CA
- Green LR
- Greenaway J
- Greenhalf W
- Gregory R
- Griffin JL
- Griffiths F
- Guest M
- Gunning P
- Gunson RN
- Gupta RK
- Gupta RK
- Gutierrez B
- Haldenby ST
- Halpin S
- Hamilton WL
- Hansford SE
- Haque T
- Hardwick H
- Hardy E
- Harris KA
- Harrison EM
- Harrison EM
- Harrison I
- Harrison J
- Hart J
- Hartley C
- Hartley JA
- Hartshorn S
- Harvey D
- Harvey M
- Harvey WT
- Hassan-Ibrahim MO
- Havalda P
- Hawcutt DB
- Heaney J
- Helmer T
- Henderson JH
- Hendry R
- Hesketh AR
- Hey J
- Heyburn D
- Higginson EE
- Hill JD
- Hill V
- Hilson RA
- Hilvers E
- Hiscox JA
- Hobrok M
- Hodgson L
- Holden MTG
- Hollis A
- Holmes A
- Holmes AH
- Holmes CW
- Holmes N
- Hopes R
- Horby PW
- Hormis A
- Hornsby HR
- Hosmillo M
- Houlihan C
- Howson-Wells HC
- Hsu NS
- Hubb J
- Huckson H
- Hughes J
- Hughes M
- Hughes W
- Hutchings S
- Idle G
- Ijaz S
- Illingworth CJ
- Impey R
- Irish-Tavares D
- Iturriza-Gomara M
- Izuagbe R
- Jackson B
- Jackson C
- Jackson C
- Jackson DK
- Jackson KA
- Jackson LM
- Jacobs M
- Jahun AS
- Jain S
- James K
- James V
- Jeanes C
- Jeffries AR
- Jennings P
- Jensen RL
- Jeremiah S
- Jermy A
- John M
- Johnson K
- Johnson R
- Johnston I
- Jones CB
- Jones CR
- Jones H
- Jones N
- Jones O
- Jones S
- Jones TR
- Joseph A
- Judges S
- Kaliappan A
- Kasipandian V
- Kay GL
- Kay S
- Keating S
- Keatley J-P
- Keeley AJ
- Kegg S
- Kelsey M
- Kendall J
- Kenyon A
- Kermack LM
- Kerrison C
- Kerslake I
- Khakh M
- Khandaker S
- Khoo S
- Kidd SP
- Kimuli M
- King K
- Kirk S
- Kitchen C
- Kitchman K
- Kiy RT
- Klenerman P
- Knight BA
- Knight JC
- Koch O
- Koduri G
- Koshy C
- Koshy G
- Koukorava C
- Kraemer MUG
- Kumziene-Summerhayes S
- Kwiatkowski D
- Lackenby A
- Laha S
- Laing KG
- Laird S
- Lake A
- Lampejo T
- Langford CF
- Lant S
- Larkin S
- Latawiec D
- Lavelle-Langham L
- Lavin D
- Law A
- Law A
- Lawton AI
- Le-Viet T
- Lee D
- Lee J
- Lee J
- Leeming G
- Lefteri D
- Leiner T
- Lensing SV
- Leonard S
- Lett L
- Levett LJ
- Lewis J
- Lewis K
- Lewis MR
- Liddle J
- Liggett S
- Liggi S
- Lillie P
- Lillie PJ
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- Publication venue
- iScience
- Publication date
- 01/01/2021
- Field of study
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.This work is supported by the UK Medical Research Council (MRC); Chinese Academy of Medical Sciences(CAMS) Innovation Fund for Medical Sciences (CIFMS), China; National Institute for Health Research (NIHR)Oxford Biomedical Research Centre, and UK Researchand Innovation (UKRI)/NIHR through the UK Coro-navirus Immunology Consortium (UK-CIC). Sequencing of SARS-CoV-2 samples and collation of data wasundertaken by the COG-UK CONSORTIUM. COG-UK is supported by funding from the Medical ResearchCouncil (MRC) part of UK Research & Innovation (UKRI),the National Institute of Health Research (NIHR),and Genome Research Limited, operating as the Wellcome Sanger Institute. T.I.d.S. is supported by a Well-come Trust Intermediate Clinical Fellowship (110058/Z/15/Z). L.T. is supported by the Wellcome Trust(grant number 205228/Z/16/Z) and by theUniversity of Liverpool Centre for Excellence in Infectious DiseaseResearch (CEIDR). S.D. is funded by an NIHR GlobalResearch Professorship (NIHR300791). L.T. and S.C.M.are also supported by the U.S. Food and Drug Administration Medical Countermeasures Initiative contract75F40120C00085 and the National Institute for Health Research Health Protection Research Unit (HPRU) inEmerging and Zoonotic Infections (NIHR200907) at University of Liverpool inpartnership with Public HealthEngland (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford.L.T. is based at the University of Liverpool. M.D.P. is funded by the NIHR Sheffield Biomedical ResearchCentre (BRC – IS-BRC-1215-20017). ISARIC4C is supported by the MRC (grant no MC_PC_19059). J.C.K.is a Wellcome Investigator (WT204969/Z/16/Z) and supported by NIHR Oxford Biomedical Research Centreand CIFMS. The views expressed are those of the authors and not necessarily those of the NIHR or MRC
Measurement of the tt¯tt¯ production cross section in pp collisions at √s=13 TeV with the ATLAS detector
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- Yoshihara K
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- Yue X
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- Zaffaroni E
- Zahreddine J
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zeitnitz C
- Zeißner SV
- Zemaityte G
- Zeng JC
- Zenin O
- Zenz S
- Zerradi S
- Zerwas D
- Zgubič M
- Zhang B
- Zhang DF
- Zhang G
- Zhang J
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- Zhang L
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- Zhang R
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- Zhang X
- Zhang X
- Zhang Z
- Zhao P
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou H
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/11/2021
- Field of study
A measurement of four-top-quark production using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 139 fb−1 is presented. Events are selected if they contain a single lepton (electron or muon) or an opposite-sign lepton pair, in association with multiple jets. The events are categorised according to the number of jets and how likely these are to contain b-hadrons. A multivariate technique is then used to discriminate between signal and background events. The measured four-top-quark production cross section is found to be 26+17−15 fb, with a corresponding observed (expected) significance of 1.9 (1.0) standard deviations over the background-only hypothesis. The result is combined with the previous measurement performed by the ATLAS Collaboration in the multilepton final state. The combined four-top-quark production cross section is measured to be 24+7−6 fb, with a corresponding observed (expected) signal significance of 4.7 (2.6) standard deviations over the background-only predictions. It is consistent within 2.0 standard deviations with the Standard Model expectation of 12.0 ± 2.4 fb
Measurements of W+W−+ ≥ 1 jet production cross-sections in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abed Abud A
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Achkar B
- Adam Bourdarios C
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akilli E
- Akimov AV
- Al Khoury K
- Alberghi GL
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alunno Camelia E
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Aranzabal N
- Araujo Ferraz V
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Arrubarrena Tame ZP
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Asimakopoulou EM
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- Zhemchugov A
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- Zinonos Z
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2021
- Field of study
Fiducial and differential cross-section measurements of W+W− production in
association with at least one hadronic jet are presented. These measurements are sensitive
to the properties of electroweak-boson self-interactions and provide a test of perturbative
quantum chromodynamics and the electroweak theory. The analysis is performed using
proton-proton collision data collected at p
s = 13TeV with the ATLAS experiment, corresponding
to an integrated luminosity of 139 fb−1. Events are selected with exactly one oppositely
charged electron-muon pair and at least one hadronic jet with a transverse momentum
of pT > 30 GeV and a pseudorapidity of |�| < 4.5. After subtracting the background
contributions and correcting for detector effects, the jet-inclusive W+W−+ � 1 jet fiducial
cross-section and W+W−+ jets differential cross-sections with respect to several kinematic
variables are measured. These measurements include leptonic quantities, such as the lepton
transverse momenta and the transverse mass of the W+W− system, as well as jet-related
observables such as the leading jet transverse momentum and the jet multiplicity. Limits on
anomalous triple-gauge-boson couplings are obtained in a phase space where interference
between the Standard Model amplitude and the anomalous amplitude is enhanced
Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s = 13 TeV
- Author
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- Abbott B
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- Abhayasinghe DK
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and Otq(8), where the limits on the latter are the most stringent to date. [Figure not available: see fulltext.]
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