Taste masking of cefuroxime axetil by ion exchange resin complex

The antibiotic cefuroxime axetil is extremely bitter. The present study deals with development of taste-masked resinates of cefuroxime axetil using ion exchange resins. The drug resin complexation procedure was optimized with respect to drug to resin ratio and pH of medium. Taste masked complex was characterized by FTIR, DSC and XRPD studies. In vitro release studies revealed complete drug release from the complex within 120 min in 0.1N HCl solution whereas less than 5 % drug was released from taste masked complex in 60 sec in simulated salivary fluid (pH 6.2) which found to be insufficient to impart bitter taste. The taste-masked complex was then formulated into a suspension dosage form using sodium carboxymethyl cellulose as suspending agent. The suspension was evaluated for various quality control parameters and in vivo studies were carried out to check bioavailability of drug from suspension.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Taste masking of oral pregabalin liquid preparation by using ion exchange resins

The purpose of this study was to use cation exchange resins to mask Pregabalin's unpleasant taste. Dowex-50, a crosslinked polystyrene backbone, was employed. DRCs were synthesised in batches with drug-to-resin ratios of 1:1, 1:2, and 1:3. The optimal drug-to-resin ratio as well as the time required for maximum complexation were discovered. In this work, an attempt was made to develop a taste-masked Pregabalin solution using a simple, rapid, and cost-effective flavour masking approach, such as complexation among ion exchange resin, that could be acceptable to industries. To mask the flavour, researchers used a combination of ion-exchange resins such as doshion P 542, Tulsion 344, Indion 234, Indion 204, and Kyron T 114, as well as formulation into a solution. The generated suspensions were tested for taste, drug content, particle size, viscosity, sedimentation volume, drug release, and accelerated stability. Kyron T 114 has been shown to effectively disguise the drug among the various resins. The newly developed formulation also has the benefit of simplifying the manufacturing process and being cost-effective. According to drug release studies, the entire medicament was released within 20 minutes.&nbsp

Development and modification of the natural polymers by converting them into nanobiocomposite

The main target ofTthis study is to develop an  antibacterial  chitosan  nanocomposite  fabric  among  in  situ   crated   silver  nanoparticles  utilizing   Vitex  leafTextract,  which  i s amedicinal herb. The CNCFs were evaluated using scanning  electron  microscopy  (SEM), Fourier transform infrared (FT-IR) spectroscopy,Xray diffraction (XRD), and antimicrobial testing. Additionally, these CNCFs have excellent antibacterial characteristics. These CNCFs could be used  in medical  applic  ations like surgical aprons, wound cleansing, wound  dressing,  and  hospital  bed  mat erials, as they were manufactured utilising a simple and environmentally acceptable approach