ODSurf : Modélisation et réalisation d'une couche de roulement de chaussée optimisée, dense et peu bruyante

ODSurf project is following a previous P2RN project dealing with the emission and propagation of rolling noise, carried out in the framework of the German-French collaboration DEUFRAKO. During P2RN, an optimum pavement texture in terms of the noise emission was calculated. The current ODSurf project was mainly dedicated to the development and implementation of low noise new technologies and new materials adapted to urban environment. Original solutions have been investigated, implemented and tested on-site. In parallel to these technological approaches, new models have been developed to better characterize various physical phenomena produced when a tyre is rolling on a textured pavement. Vibration phenomena, air pumping and the horn effect were specifically studied and the main results are detailed in this document. In addition to the modelling approach, this project includes a strong experimental component useful for model validation and also to allow an acoustic classification of road surfaces. The measures presented in this report were carried out both on test tracks and actual site on which were positioned the optimized conventional or industrially designed coatings, both in France and Germany. Finally, this report is ending with the common database "DEUFRABASE". It includes the noise produced by light and heavy vehicles running on a large panel of French and German road surfaces for various propagation configurations. Updated at the end of the project, this database posted on the Ifsttar server will be soon freely available online. From its current design, it will easily allow regular updates in terms of site configurations and new road surfaces. It thus will be a good tool to estimate the acoustic impact of traffic for many suburban and urban situations. Following the results achieved during the project, the next steps will concern on one hand, the improvement and integration of the various modelling approaches of different tyre noise generation phenomena in a "unique" tool in order to have an overall estimation of the impact of road surfaces on the sound level produced by road traffic and secondly, to extend the DEUFRABASE to more realistic situations.Le projet ODSurf fait suite à un précédent projet P2RN, relatif à l'émission et la propagation du bruit de roulement, réalisé dans le cadre de la collaboration franco-allemande DEUFRAKO. Au cours de P2RN, une texture de chaussée optimale du point de vue de l'émission sonore avait été calculée. L'actuel projet ODSurf a été principalement dédié à l'élaboration et la mise en oeuvre de nouvelles technologies à faible bruit et de nouveaux matériaux adaptés au milieu urbain. Des solutions originales ont été imaginées, mises en oeuvre sur site et testées. Parallèlement à ces approches technologiques, de nouveaux modèles ont été développés pour mieux caractériser les divers phénomènes physiques mis en jeu lors du roulement d'un pneumatique sur une chaussée texturée. Les phénomènes vibratoires, de pompage d'air ainsi que l'effet dièdre ont été plus particulièrement étudiés et les principaux résultats sont détaillés dans le présent document. Outre l'approche modélisation, ce projet a fait l'objet d'une forte composante expérimentale utile à la fois pour la validation des modèles mais aussi pour permettre une classification acoustique des revêtements routiers. Les mesures présentées dans ce rapport ont été réalisées à la fois sur pistes d'essai et sur site réel sur lesquels ont été mis en place les revêtements optimisés de conception classique ou industrielle, tant en France et qu'en Allemagne. Enfin, ce document se termine par la base de données commune « DEUFRABASE ». Elle regroupe les émissions sonores produites par le roulement de véhicules légers et lourds sur un large panel de revêtements routiers français et allemands pour diverses configurations de propagation. Mise à jour en fin de projet, cette base déposée sur le serveur de l'Ifsttar sera prochainement accessible gratuitement en ligne. De par sa conception actuelle, elle permettra aisément des mises à jour régulières tant en termes de configurations de sites que de nouveaux revêtements de chaussée. Elle permettra ainsi d'être un bon outil pour estimer l'impact acoustique du trafic routier pour de multiples configurations périurbaines et urbaines. A la lumière des résultats enregistrés au cours de ce projet, les étapes futures concerneront d'une part, l'amélioration et l'intégration des diverses approches de modélisation des différents phénomènes de génération de bruit de roulement dans un outil « unique » afin d'avoir une estimation globale de l'impact des couches de roulement sur le niveau sonore produit par le trafic routier et d'autre part, d'étendre la DEUFRABASE à un plus grand nombre de situations réalistes

Investigating Factors Associated with Depressive Symptoms of Chronic Kidney Diseases in China with Type 2 Diabetes

Aim. To assess the depressive symptoms status of chronic kidney diseases in Nantong, China, with type 2 diabetes and to identify factors associated with depressive symptoms. Methods. In this cross-sectional analytic study, 210 type 2 diabetic patients were recruited from the Second Affiliated Hospital of Nantong University. Depressive symptoms were assessed with the depression subscale of the Hospital Anxiety and Depression Scale (HAD-D). The quality of life was measured with the RAND 36-Item Health Survey (SF-36). And the independent risk factors of depressive symptoms were assessed by using a stepwise forward model of logistic regression analysis. Results. The mean age of the study subjects was 57.66 years (SD: 11.68). Approximately 21.4% of subjects reported depressive symptoms (n=45). Forward stepwise logistic regression analysis showed that female gender (P=0.010), hypertension (P=0.022), Stage IV (P=0.003), and Stage V (P<0.001) were significant risk factors for depressive symptoms. The quality of life of individuals with HAD-D score <11 was significantly better compared with individuals with HAD-D score ≥ 11. Conclusions. These results indicate that clinicians should be aware that female patients with chronic kidney diseases with T2DM in their late stage with hypertension are at a marked increased risk of depressive symptoms. Providing optimal care for the psychological health of this population is vital

A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus.

MicroRNAs (miRNAs) are small noncoding RNAs that modulate the cellular transcriptome at the post-transcriptional level. miRNA plays important roles in different disease manifestation, including type 2 diabetes mellitus (T2DM). Many studies have characterized the changes of miRNAs in T2DM, a complex systematic disease; however, few studies have integrated these findings and explored the functional effects of the dysregulated miRNAs identified. To investigate the involvement of miRNAs in T2DM, we obtained and analyzed all relevant studies published prior to 18 October 2016 from various literature databases. From 59 independent studies that met the inclusion criteria, we identified 158 dysregulated miRNAs in seven different major sample types. To understand the functional impact of these deregulated miRNAs, we performed targets prediction and pathway enrichment analysis. Results from our analysis suggested that the altered miRNAs are involved in the core processes associated with T2DM, such as carbohydrate and lipid metabolisms, insulin signaling pathway and the adipocytokine signaling pathway. This systematic survey of dysregulated miRNAs provides molecular insights on the effect of deregulated miRNAs in different tissues during the development of diabetes. Some of these miRNAs and their mRNA targets may have diagnostic and/or therapeutic utilities in T2DM

Investigating Factors Associated with Depressive Symptoms of Chronic Kidney Diseases in China with Type 2 Diabetes

Aim. To assess the depressive symptoms status of chronic kidney diseases in Nantong, China, with type 2 diabetes and to identify factors associated with depressive symptoms. Methods. In this cross-sectional analytic study, 210 type 2 diabetic patients were recruited from the Second Affiliated Hospital of Nantong University. Depressive symptoms were assessed with the depression subscale of the Hospital Anxiety and Depression Scale (HAD-D). The quality of life was measured with the RAND 36-Item Health Survey (SF-36). And the independent risk factors of depressive symptoms were assessed by using a stepwise forward model of logistic regression analysis. Results. The mean age of the study subjects was 57.66 years (SD: 11.68). Approximately 21.4% of subjects reported depressive symptoms ( = 45). Forward stepwise logistic regression analysis showed that female gender ( = 0.010), hypertension ( = 0.022), Stage IV ( = 0.003), and Stage V ( &lt; 0.001) were significant risk factors for depressive symptoms. The quality of life of individuals with HAD-D score &lt;11 was significantly better compared with individuals with HAD-D score ≥ 11. Conclusions. These results indicate that clinicians should be aware that female patients with chronic kidney diseases with T2DM in their late stage with hypertension are at a marked increased risk of depressive symptoms. Providing optimal care for the psychological health of this population is vital

Differences in rhizospheric microbial communities between cultivated and wild endangered Glyptostrobus pensilis

Glyptostrobus pensilis is an endangered species belonging to the Cupressaceae family. The comprehensive examination of soil characteristics and rhizosphere microbial communities is vital for conservation efforts, as it provides insights into the necessary environmental conditions for safeguarding and ensuring the viability of rare and endangered species. In this study, the diversity and composition of bacterial and fungal communities were compared in the roots and rhizosphere soils of cultivated and wild G. pensilis in Guangxi, China. The results revealed that, at the phylum level, the rhizosphere of cultivated G. pensilis was significantly enriched with Verrucomicrobiota, Acidobacteriota, Glomeromycota, and Chloroflexi, while wild G. pensilis was significantly enriched with Planctomycetota, Basidiomycota, and Ascomycota. Symbiotic network analysis indicated that the bacterial network in the cultivated G. pensilis rhizosphere had higher edge values, average degree, clustering coefficient, and network density, while the fungal network in the wild G. pensilis rhizosphere had higher node values, edge values, average degree, and clustering coefficient. Moreover, functional prediction results suggested that bacteria in cultivated G. pensilis showed higher metabolic activity, with fungi primarily acted as saprotrophs and symbionts. In contrast, bacteria in wild G. pensilis displayed lower metabolic activity, with fungi predominantly functioning as saprotrophs. The analysis linking rhizospheric microbial diversity to soil environmental factors showed a closer association for the wild G. pensilis microbial community, suggesting a stronger influence of soil environmental factors. The Random Forest (RF) highlighted that the total phosphorus and total potassium levels were key influencing factors for rhizospheric microbes in cultivated G. pensilis, while available potassium levels were crucial for those in wild G. pensilis. These differences underscore the significant strategies for G. pensilis in adapting to different habitats, which may be intricately linked to land management practices and soil environmental factors. Among these, phosphorus and potassium are significantly associated with the rhizosphere microorganisms of G. pensilis. Therefore, continuous monitoring of nutrient availability and regular supplementation of phosphorus and potassium fertilizers in the rhizosphere are recommended during the cultivation and ex-situ conservation of G. pensilis

Effects of supplemental lighting with different light qualities on growth and secondary metabolite content of Anoectochilus roxburghii

Background Anoectochilus roxburghii is a widespread herbaceous plant with high medicinal value. Wild A. roxburghii resources face extinction due to their slow growth rate and over exploitation. The growing market demand has led to advances in the field of artificial planting of A. roxburghii. Methods to increase the economic benefits of cultivation and the production of medicinal ingredients are very useful. Methods A. roxburghii was exposed to red light, blue light (BL), yellow light (YL), green light, or white light as supplemental lighting at night (18:00–02:00) in a greenhouse or were left in darkness (control, CK) to investigate the effects of various light qualities on growth indices, photosynthetic pigments, chlorophyll fluorescence, root vitality, stomatal density, soluble proteins, sugars, and the accumulation of secondary metabolites. Results Supplementation of BL had a positive effect on A. roxburghii growth and secondary metabolite accumulation. Leaf number, stem diameter, fresh weight, dry weight, chlorophyll a content, and secondary metabolite (total flavonoids, total polyphenols) content increased significantly. YL treatment showed significantly higher soluble sugar and polysaccharide contents than the control. Discussion BL treatment was conducive to promoting the growth and accumulation of secondary metabolites (total flavonoids, total polyphenols); YL treatment significantly increased the content of soluble sugar and polysaccharides more than the control. Polysaccharides and total flavonoids are important medicinal ingredients of Anoectochilus, so future research will focus on the combination of blue and YL

Deciphering male influence in gynogenetic Pengze crucian carp (Carassius auratus var. pengsenensis): insights from Nanopore sequencing of structural variations

In this study, we investigate gynogenetic reproduction in Pengze Crucian Carp (Carassius auratus var. pengsenensis) using third-generation Nanopore sequencing to uncover structural variations (SVs) in offspring. Our objective was to understand the role of male genetic material in gynogenesis by examining the genomes of both parents and their offspring. We discovered a notable number of male-specific structural variations (MSSVs): 1,195 to 1,709 MSSVs in homologous offspring, accounting for approximately 0.52%–0.60% of their detected SVs, and 236 to 350 MSSVs in heterologous offspring, making up about 0.10%–0.13%. These results highlight the significant influence of male genetic material on the genetic composition of offspring, particularly in homologous pairs, challenging the traditional view of asexual reproduction. The gene annotation of MSSVs revealed their presence in critical gene regions, indicating potential functional impacts. Specifically, we found 5 MSSVs in the exonic regions of protein-coding genes in homologous offspring, suggesting possible direct effects on protein structure and function. Validation of an MSSV in the exonic region of the polyunsaturated fatty acid 5-lipoxygenase gene confirmed male genetic material transmission in some offspring. This study underscores the importance of further research on the genetic diversity and gynogenesis mechanisms, providing valuable insights for reproductive biology, aquaculture, and fostering innovation in biological research and aquaculture practices

Molecular cloning and expression analysis of the MaASR1 gene in banana and functional characterization under salt stress

Background: Abscisic acid (ABA)-, stress- and ripening-induced protein (ASR) is plant-specific hydrophilic transcriptional regulators involved in sucrose stress and wounding in banana. However, it is not known whether banana ASR genes confer salt stress tolerance. The contexts of the studywas to analysis the sequence characterization of banana ASR1, and identify its expression patterns and function under salt stress using quantitative real-time PCR (qPCR) and overexpression in Arabidopsis . The purpose was to evaluate the role of banana ASR1 to salt stress tolerance employed by plants. Results: A full-length cDNA isolated from banana fruitwas named MaASR1, and it had a 432 bp open reading frame (ORF) encoding 143 amino acids. MaASR1 was preferential expression in roots and leaves compared to low expression in fruits, rhizomes and flowers. Under salt stress, the expression of MaASR1 quickly increased and highest expression level was detected in roots and leaves at 4 h, and then gradually decreased. These results suggested that MaASR1 expression was induced under salt stress. MaASR1 protein was localized in the nucleus and plasma membrane. MaASR1 was transformed to Arabidopsis and verified by southern and northern analysis, transgenic lines L14 and L38 integrated one and two copies of MaASR1, respectively, while overexpression in transgenic lines provided evidence for the role of MaASR1 to salt stress tolerance. Conclusions: This study demonstrated that overexpression of MaASR1 in Arabidopsis confers salt stress tolerance by reducing the expression of ABA/stress-responsive genes, but does not affect the expression of the ABA-independent pathway and biosynthesis pathway genes

Body Image Disturbances Have Impact on the Sexual Problems in Chinese Systemic Lupus Erythematosus Patients

SLE might affect all aspects of life including sexual functioning; previous study found that body image disturbance (BID) was the most powerful predictors of impaired partner relationships and sexual function. The current study investigated the relationship among disease parameters, quality of life, the psychological status, BID, and sexual problems in Chinese patients with SLE. A self-report survey design was administered to 168 SLE patients and 210 healthy individuals. Our results showed that 86 (55.1%) SLE patients reported impaired relationships with a sexual partner or partners, and 100 (64.1%) patients reported impaired sexual function which were significantly higher than the control group (31.6%, 35.7%, rep.). Age, marital status, depression, and BIDQ were the most powerful predictors of impaired partner relationships, while BIDQ3 and education, disease activity, and depression were the most significant causes of impaired sexual function. The study for first time reported Chinese SLE patients had sexual problems and BID was associated with sexual problems. So, early detection and interventions might not only rehabilitate the patients and their loved ones, but also improve overall health outcomes and reduce the direct and indirect costs of their medical care