Enhancing Classification Performance through FeatureBoostThyro: A Comparative Study of Machine Learning Algorithms and Feature Selection

Early-stage prediction of a disease is an important and challenging task. The application of machine learning techniques is playing an important role in this era. Thyroid is one of the chronic endocrine diseases, and approximately 42 million people in India are affected by this disease. This paper presents a comprehensive investigation into the enhancement of classification performance through the novel ‘FeatureBoostThyro’ (FBT) model. The study evaluates various machine learning algorithms, including stochastic gradient descent (SGD), K nearest neighbor (KNN), logistic regression (LR), naive bayes (NB), and support vector machine (SVM), in conjunction with diverse feature selection methods. The research systematically explores the impact of feature selection techniques such as information gain, relief F, chi-square, gini index, forward selection, backward selection, recursive feature elimination, and LASSO on model performance across the chosen algorithms. The analysis reveals notable variations in performance metrics, including accuracy, precision, recall, and F1-score, providing valuable insights into the interplay between algorithm and feature selection. One main contribution of this research is the introduction of the FBT model, which consistently outperforms other models across various feature selection methods, making it a promising tool for addressing complex classification tasks. The findings contribute to a broader understanding of model selection and optimization in machine learning applications. The proposed model undergoes evaluation using two distinct datasets: the primary dataset acquired from Lata Mangeshkar Hospital in Nagpur and the secondary dataset obtained from the UCI dataset

Comparison of two ultra-widefield cameras with high image resolution and wider view for identifying diabetic retinopathy lesions

Purpose: To compare the effectiveness of the Optos P200dTx and Zeiss Clarus 50fundus cameras in detecting diabetic retinopathy (DR) lesions. Methods: A cross-sectional study was conducted among 243 patients with clinically diagnoseddiabetesmellituswhowerereferredforaneyeexaminationfromtwotertiary eye care centers in Chennai, India. Patients underwent DR screening based on mydriatic fundal images acquired by both fundal cameras. Fundal images from the two separate devices for each eye were compared based on accurately identified pathological retinal lesions with respect to type and location. Results: When studying lesions of the central retina, they were better identified by the Zeiss Clarus compared with the Optos P200dTx, with six out of eight being statistically significant (P < 0.05). However, lesions of the mid-peripheral retina and peripheral retina were better identified by the Optos P200dTx than the Zeiss Clarus, with three out of eight lesions and five out of eight lesions being statistically significant (P < 0.05), respectively. Based on the color and size of lesions, the Optos P200dTx had a higher chance (59.6%) of missing white lesions than did the Zeiss Clarus (17%) (P < 0.0001). Consequently, small-and medium-sized lesions were missed more by the Optos P200dTx (30.72% and 32.63%, respectively) than the Zeiss Clarus (22.3% and 19.30%, respectively). Conclusions: The capability of detecting or missing a particular DR lesion among diabetics differed between the two cameras based on effective field of view, resolution, and the retinal zone being imaged. Translational Relevance: The choice of which ultra-widefield camera to be used for screening DR can be based on the greater prevalence of central versus peripheral retinal lesions noted in the patient population seen in a clinical practice

Management as a factor of production in the semi-arid tropics of rural South India

Using time series, cross-sectional data, the paper describes and explains interfarm variations in managerial performance in the semi arid tropics of rural South India. The study focuses on the consequences of personal characteristics on efficiency as measured by relative productivity differences in net returns to management. Managerial performance is statistically evaluated with respect to farmers in the same village. The study is based on data for five cropping years from 1975/76 to 1979/80 collected from the ICRISAT Village Level Studies. Farming experience was the overriding consideration separating good from bad managers. Older farmers, those born into traditional farming, and those who practised hands-on farming, had significantly higher returns to management. These results emphasize the importance in understanding occupational status by migration interactio

Early adoption of improved vertisol technology options and double cropping in Begumgunj, Madhya Pradesh

Perceptions of 25 verification trial watershed and neighboring farmers were elicited to assess the early acceptance of the Vertisol technology options tested in Begumgunj from 1982-83 to 1984-85. The economic analysis showed the main economic advantage of the improved technology stemmed from the highly profitable soybean/pigeonpea intercrop which substituted for traditional rainy season fallow - postrainy season wheat. Despite its impressive performance in the trials, interest in the soybean/pigeonpea intercrop has waned with only four of 25 farmers growing it in 1986-87. Frost risk was the most common explanation for the lack of interest. Preference for postrainy season subsistence crops instead of pigecnpea was also cited by several farmers. Not mentioned by farmers, but perhaps an important explanation, is tne difficulty of suing intercrops in rows with modern seed drills..

Common Features and Contrasts in Labor Relations in the Semiarid Tropics of India

The main objectives of this paper are (1) to document and explain labor market arrangements in different agroclimatic and socioeconomic zones on the basis of intensive survey data; (2) to explore linkages of transactions in labor markets with transactions in other markets such as those for credit, draft power, and outputs, as well as linkages between caste status and type of labor performed; and (3) to characterize, as far as possible, the changes, if any, in labor relations over time

Common Features And Contrasts In Labor Relations In The Semiarid Tropics Of India

'I he niaitt ohjcctivcs of this paper are (I) to document and explain labor market arranpcnients in tlifl'ercnt agroclimatic and socicwonomic zones on the basis of intensive survey data; (2) to explore linkages of transactions in labor ninrkets \rith transactions in other mnrkets such as those for credit. dral't po\sfer, ant1 outpitt~a. s well as linkages bctween caste status and type of labor perfornied: and (3) to characterize. iIS far as possible. thc changes. if any, in labor relations over time

Methylation-Dependent Binding of the Epstein-Barr Virus BZLF1 Protein to Viral Promoters

The switch between latent and lytic Epstein-Barr virus (EBV) infection is mediated by the viral immediate-early (IE) protein, BZLF1 (Z). Z, a homologue of c-jun that binds to AP1-like motifs (ZREs), induces expression of the BRLF1 (R) and BRRF1 (Na) viral proteins, which cooperatively activate transcription of the Z promoter and thereby establish a positive autoregulatory loop. A unique feature of Z is its ability to preferentially bind to, and activate, the methylated form of the BRLF1 promoter (Rp). To date, however, Rp is the only EBV promoter known to be regulated in this unusual manner. We now demonstrate that the promoter driving transcription of the early BRRF1 gene (Nap) has two CpG-containing ZREs (ACGCTCA and TCGCCCG) that are only bound by Z in the methylated state. Both Nap ZREs are highly methylated in cells with latent EBV infection. Z efficiently activates the methylated, but not unmethylated, form of Nap in reporter gene assays, and both ZREs are required. Z serine residue 186, which was previously shown to be required for Z binding to methylated ZREs in Rp, but not for Z binding to the AP1 site, is required for Z binding to methylated Nap ZREs. The Z(S186A) mutant cannot activate methylated Nap in reporter gene assays and does not induce Na expression in cells with latent EBV infection. Molecular modeling studies of Z bound to the methylated Nap ZREs help to explain why methylation is required for Z binding, and the role of the Z Ser186 residue. Methylation-dependent Z binding to critical viral promoters may enhance lytic reactivation in latently infected cells, where the viral genome is heavily methylated. Conversely, since the incoming viral genome is initially unmethylated, methylation-dependent Z activation may also help the virus to establish latency following infection

Multivariable control of a grid-connected wind energy conversion system with power quality enhancement

This document is the Accepted Manuscript version of the following article: Kaddour Fouad, Houari Merabet Boulouiha, Ahmed Allali, Ali Taibi, and Mouloud Denai, ‘Multivariable control of a grid-connected wind energy conversion system with power quality enhancement’, Energy Systems, Vol. 9 (1): 25-57, February 2018. The final publication is available at Springer via: https://doi.org/10.1007/s12667-016-0223-7This paper proposes the design of a multivariable robust control strategy for a variable-speed WECS based on a SCIG. Optimal speed control of the SCIG is achieved by a conventional PI controller combined with a MPPT strategy. DTC-SVM technique based on a simple Clarke transformation is used to control the generator-side three-level converter in the variable speed WECS. The flow of real and reactive power between the inverter and the grid is controlled via the grid real and reactive currents and the DC link voltage using multivariable H∞ control. The overall WECS and control scheme are developed in Matlab/Simulink and the performance of the proposed control strategy is evaluated via a set of simulation scenarios replicating various operating conditions of the WECS such as variable wind speed and asymmetric single grid faults. The power quality of the WECS system under H∞ control control approach is assessed and the results show a significant improvement in the total harmonic distorsion as compared to that achieved with a classical PI control.Peer reviewedFinal Accepted Versio

Methylation profiling of Epstein-Barr virus immediate-early gene promoters, BZLF1 and BRLF1 in tumors of epithelial, NK- and B-cell origins

<p>Abstract</p> <p>Background</p> <p>Epstein-Barr virus (EBV) establishes its latency in EBV-associated malignancies, accompanied by occasionally reactivated lytic cycle. Promoter CpG methylation of EBV genome plays an essential role in maintaining viral latency. Two immediate-early (IE) genes, BZLF1 and BRLF1, induce the switch from latent to lytic infection. Studies of methylation-dependent binding of BZLF1 and BRLF1 to EBV promoters have been well reported, but little is known about the methylation status of <it>BZLF1 </it>and <it>BRLF1 </it>promoters (Zp and Rp) in tumor samples.</p> <p>Methods</p> <p>We evaluated the methylation profiles of Zp and Rp by methylation-specific PCR (MSP) and bisulfite genomic sequencing (BGS), as well as <it>BZLF1 </it>and <it>BRLF1 </it>expression by semiquantitative reverse transcription (RT)-PCR in tumors of epithelial, NK- and B-cell origins.</p> <p>Results</p> <p>We found that both Zp and Rp were hypermethylated in all studied EBV-positive cell lines and tumors of lymphoid (B- or NK cell) or epithelial origin, while unmethylated Zp and Rp alleles were detected in cell lines expressing <it>BZLF1 </it>and <it>BRLF1</it>. Following azacytidine treatment or combined with trichostatin A (TSA), the expression of <it>BZLF1 </it>and <it>BRLF1 </it>was restored along with concomitant promoter demethylation, which subsequently induced the reactivation of early lytic gene <it>BHRF1 </it>and late lytic gene <it>BLLF1</it>.</p> <p>Conclusions</p> <p>Hypermethylation of Zp and Rp mediates the frequent silencing of <it>BZLF1 </it>and <it>BRLF1 </it>in EBV-associated tumors, which could be reactivated by demethylation agent and ultimately initiated the EBV lytic cascade.</p