Spontaneous bilateral adrenal hemorrhage of pregnancy

Spontaneous adrenal hemorrhage of pregnancy is an acute hemorrhage into the adrenal gland in pregnancy in the absence of trauma, tumor or decoagulant therapy. This can have catastrophic consequences on the mother and the baby and if the hemorrhage involves both the adrenal glands the risk is aggravated because of the high incidence of resulting adrenal insufficiency. We report a case of spontaneous bilateral adrenal hemorrhage in pregnancy resulting in adrenal crisis. A 26 year old primigravida presented at 32 weeks of gestation initially with right sided infrascapular pain and one month later with similar pain in the left side associated with high blood pressure. Imaging with ultrasound and MRI was suggestive of bilateral adrenal mass probably hemorrhage; 2 days following the second episode of pain she developed drowsiness and hypotension and a diagnosis of primary adrenal insufficiency was confirmed by a low serum cortisol and high ACTH. She stabilized with hydrocortisone therapy and the fetus was closely monitored. At 37 weeks she had a normal vaginal delivery under steroid cover. Repeat MRI abdomen 3 months after delivery showed resolution of the hemorrhage but biochemically she continued to be cortisol insufficient at 1 year of follow up. Prompt diagnosis of adrenal hemorrhage in pregnancy and treatment of adrenal insufficiency along with close fetal monitoring usually results in good perinatal outcome in spontaneous adrenal hemorrhage of pregnancy

IMPLEMENTATION OF INTERNET BROWSING ON SET TOP BOX USING ARM LINUX

Internet browser such as Mozilla, IE etc. is a computer program which allows a person to show and communicate with text, images, videos, music along with other information on the web. There's a necessity to integrate Internet browsing feature on Tuner (STB) being an additional feature to supply value to interactive television services. Despite the fact that it is possible to perform this type of task, but supplying a great design having a capable processor and operating system which can handle handling more present and advanced with economical looks to become challenging. The Expansion atmosphere requires a Desktop with Linux OS configured with 32 bit Direct Facebook package. The Frame Buffer support needs to be enabled during Linux Installation. ARM core processors and Linux operating-system (OS) may are employed in implementation of interactive television. ARM is among the most licensed and therefore prevalent processor cores on the planet and used particularly in portable products because of low power consumption and reasonable performance (MIPS / watt) and Linux is definitely a free operating-system with higher versatility and guaranteed tile system. Present paper presents an implementation of Internet browsing baked into STB using ARM processors and Linux OS.

Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage

Serine hydroxymethyltransferase (SHMT) from Bacillus stearothermophilus (bsSHMT) is a pyridoxal 5′-phosphate-dependent enzyme that catalyses the conversion of L-serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. In addition, the enzyme catalyses the tetrahydrofolate-independent cleavage of 3-hydroxy amino acids and transamination. In this article, we have examined the mechanism of the tetrahydrofolate-independent cleavage of 3-hydroxy amino acids by SHMT. The three-dimensional structure and biochemical properties of Y51F and Y61A bsSHMTs and their complexes with substrates, especially L-allo-Thr, show that the cleavage of 3-hydroxy amino acids could proceed via Cα proton abstraction rather than hydroxyl proton removal. Both mutations result in a complete loss of tetrahydrofolate-dependent and tetrahydrofolate-independent activities. The mutation of Y51 to F strongly affects the binding of pyridoxal 5′-phosphate, possibly as a consequence of a change in the orientation of the phenyl ring in Y51F bsSHMT. The mutant enzyme could be completely reconstituted with pyridoxal 5′-phosphate. However, there was an alteration in the λmax value of the internal aldimine (396 nm), a decrease in the rate of reduction with NaCNBH3 and a loss of the intermediate in the interaction with methoxyamine (MA). The mutation of Y61 to A results in the loss of interaction with Cα and Cβ of the substrates. X-Ray structure and visible CD studies show that the mutant is capable of forming an external aldimine. However, the formation of the quinonoid intermediate is hindered. It is suggested that Y61 is involved in the abstraction of the Cα proton from 3-hydroxy amino acids. A new mechanism for the cleavage of 3-hydroxy amino acids via Cα proton abstraction by SHMT is proposed

Seroprevalence of transfusion transmitted infections in voluntary and replacement blood donors in a tertiary care hospital blood bank of Anantapur, Andhra Pradesh, India: 5 years retrospective study

Background: Critical part of transfusion is effective screening of TTI, to reduce the risk of transmission is as safe as possible. The present study has undertaken to focus on seroprevalence of TTIs among both voluntary and replacement donors and also to project epidemiological data of TTIs in this community.Methods: This is a retrospective study conducted from January 2014 to December 2018. All blood samples collected from donors were screened for HIV, HBV, HCV, Syphilis and malaria according to blood bank policy. Before drawing blood, donors were asked to fill pre structured Blood bank questionnaire and consent form.Results: In this present 5-year study, total number of blood donor population was 54937, among them voluntary donors were 33891 and replacement donors were 21046. Out of 33891 voluntary donors, 33486(98.8%) were males and remaining 405(1.19%) were females. All replacement donors (21046) were males. The seroprevalence of HBV was highest, 1.82% (1003/54937) followed by HCV 0.31% (175/54937) in all the donors. The seropositivity for HIV is 0.23% (129/54937), for syphilis 0.04% (24/54937) and for malaria 0.01% (6/54937).Conclusions: National blood transfusion policy should be strengthening the standards and quality of screening across the country. For blood screening, resources and appropriate screening assays must be available at all health centres

Dietary Diversity and Its Relationship with Nutritional Status among Adolescents and Adults in Rural India

Dietary diversity is associated with household or individual food availability and intake of nutrients from different food groups and is an important component of nutritional outcome. This study examined the Nutrient Adequacy Ratio (NAR) and the Mean Adequacy Ratio (MAR) of three dietary diversity indices and their relationship with the nutritional status of adolescents and adults in rural regions of two states in India, Wardha district in Maharashtra and Koraput district in Odisha, in 2014. Individual dietary diversity was calculated using 24-hour diet recall (FS24hr) data and household dietary diversity was measured with food frequency data using Berry’s index (DDI) and food scores (FSFFQ). The nutritional status of individuals was assessed using anthropometric indices. The diets in both locations were cereal dominated. It was observed that 51% of adolescent boys and 27% of adolescent girls had ‘thinness’ and stunting. The prevalence of undernutrition was higher among adult women (48%) than adult men (36%). The mean diversity indices were FS24hr of 8, DDI of 89–90 and FSFFQ of 64–66 in the two locations. The FS24hr was found to be positively correlated with the NAR of all nutrients while DDI and FSFFQ were correlated with seven and six nutrients, respectively. The DDI and FS24hr showed an association with MAR if the two locations were combined together. Sensitivity and specificity analysis showed that FS24hr gave more true positives than false positives and the area under the Receiver Operating Characteristic curve was 0.68, implying that this measure truly differentiates individuals having low dietary diversity with low MAR from those with low dietary diversity and a high MAR. All three measures of dietary diversity showed a linear association with the nutritional outcomes of adults, while in the adolescent group only DDI showed a relationship. It is concluded that 24-hour diet recall is a good measure for studying the relationship between dietary diversity and nutritional status in adults

HRI – "In the wild” In Rural India: A Feasibility Study

This work was conducted to investigate the technological acceptance and social perception of a robot helper in a rural context. A feasibility study was carried out in a rural village in India with 11 participants with a water carrying task for the robot. A strong cultural influence was found in terms of gender perception of the robot, most participants perceived the robot’s gender as a female despite of the robot having a male’s voice. The overall social perception and usefulness of the robot was observed to be positive. We report some initial results and also some practical and logistical challenges while running such studies “in the wild” with rural subjects in this paper

IMPACT OF OZONE CONCENTRATION ON OCEAN COLOUR RETRIEVALS FOR OCM-2

Ozone being an absorbing gas have a significant impact on OCM-2 bands 510 nm, 555 nm and 620 nm which are using for retrieval of major geophysical parameters like Chlorophyll and suspended sediment concentrations. A study has been carried out to analyse the impact of Ozone concentration by ingesting near real time from OMI (Ozone Monitoring Instrument) on Aura instead of Climatology V2013 (2004–13) with a resolution of 1 × 1 deg for ocean colour retrievals from OCM-2 sensor using SeaWiFS Data Analysis System (SeaDAS). The spectral behaviour of Ozone transmittance has been studied for various bands of OCM-2 by using both Climatology and near real time inputs. We could observe maximum relative error percentage about 12 % from Climatology to NRT in Ozone concentration and 0.28 %, 0.66 % and 0.72 % of maximum mean relative error in ozone transmittance at 512 nm, 557 nm and 620 nm. We calculated error budgets induced by ozone in remote sensing reflectance(/sr) where in we could observe mean relative error percentage of 0.52 % in 491 nm, 1.12 % in 512 nm and 4.28 % 557 nm a bands respectively

Child Under-weight and Agricultural Productivity in India: Implications for Public Provisioning and Women’s Agency

This study is part of the ongoing research program on Leveraging Agriculture for Nutrition in South Asia (LANSA) funded by UK Aid from the Department for International Development, UK. The authors are consultants or regular staff of M.S. Swaminathan Research Foundation, India, one of the six partner institutions of LANSA.A recent global hunger index indicated a 12 percent decline in child underweight rates. This study attempts an empirical explanation of the factors that influence child underweight rates at the district level. Agricultural land productivity, share of women educated above the secondary level and participating in work, maternal, and child health seem to contribute to the reduction in child underweight. However government health and water supply facilities turn out to be ineffective