Testosterone replacement therapy among HIV-infected men in the CFAR Network of Integrated Clinical Systems

The objectives of this study were to determine the rate of testosterone replacement therapy (TRT) initiation, TRT predictors and associated monitoring in HIV-infected men

Consumo de drogas ilegales, apoyo familiar y factores relacionadosen estudiantes universitarios. Un estudio transversal basado en datosdel Proyecto uniHcos

Objective: To assess the prevalence of illegal drug use in college students on any previous occasion, duringthe previous year and the previous month, and to analyze the relationship between illegal drug use andfamily support and other factors.Methods: A cross-sectional study using data from students participating in the uniHcos project (n = 3767)was conducted. The prevalence and age of onset of consumption of cannabis, non-prescription sedatives,stimulants and depressants was evaluated. Polyconsumption was also assessed. The independent vari-ables were: family support, age, residence, and employment status. To determine the factors related todrug use multivariate logistic regression models stratified by gender were fitted.Results: Differences between men and women in prevalence of illegal drug use except non-prescriptionsedatives were observed. In both genders, less family support was associated with higher consumptionof all drugs, except depressants, and with polyconsumption. To be studying and looking for work wasrelated to cannabis and stimulant use and to polyconsumption among women, but only to cannabis useamong men.Conclusions: These results support the notion that the start of university studies is a particularly relevantstage in the onset of illegal drug use and its prevention, and that consumption may be especially associatedwith family support.Objetivo: Evaluar la prevalencia del consumo de drogas ilegales en estudiantes universitarios y analizarla relación entre dicho consumo, el apoyo familiar y otros factores.Método: Se realizó un dise?no transversal basado en datos de participantes en el proyecto uniHcos (n =3767). Se evaluaron la prevalencia y la edad de inicio del consumo de cannabis, tranquilizantes sin receta,estimulantes y depresores, y el policonsumo. Como variables independientes se consideraron el apoyofamiliar, la edad, la residencia y la situación laboral. Para la determinación de los factores asociados alconsumo de drogas se ajustaron modelos de regresión logística estratificados por sexo.Resultados: Se observaron diferencias entre hombres y mujeres en la prevalencia del consumo de todaslas drogas ilegales, excepto tranquilizantes sin receta. En ambos sexos, cuanto peor apoyo familiar, mayorconsumo de todas las drogas, excepto depresores y policonsumo. Encontrarse estudiando y buscandotrabajo se relacionó con el consumo de cannabis, estimulantes y policonsumo en las mujeres, y solo concannabis en los hombres.Conclusiones: Los resultados de este estudio aportan nueva evidencia a favor de que el inicio de la etapauniversitaria es un momento de especial relevancia en el inicio del consumo de drogas ilegales y suprevención, pudiendo este consumo estar especialmente relacionado con el apoyo familiar

Prevalence, anatomic distribution, and correlates of Chlamydia trachomatis and Neisseria gonorrhoeae infections among a cohort of men who have sex with men in Hanoi, Vietnam

Background: Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) disproportionately affect men who have sex with men (MSM). Data on the prevalence, anatomical distribution, and correlates of NG and CT infections among MSM in Vietnam are limited.Methods: Between July 2017 and April 2019, MSM 16 years or older, without HIV were enrolled into an observational cohort study. Baseline data, including sociodemographics, sexual behavior, and HIV status were collected. NG and CT testing were performed on urine, rectal, and pharyngeal specimens. Multivariate logistic regression models identified factors associated with NG and CT infections at baseline.Results: In total, 1489 participants underwent NG/CT testing. The median age was 22 years (IQR: 20 – 26). There were 424 (28.5%) NG or CT infections; 322 (21.6%) with CT and 173 (11.6%) with NG. Rectal infections were most common for CT (73.9%), while pharyngeal infections were most common for NG (70.5%). Independent risk factors for CT or NG infection included: ≥2 sex partners in the prior month (adjusted odds ratio [aOR] = 2.04; 95% CI: 1.44, 2.91), condomless anal sex (aOR = 1.44, 95% CI: 1.12, 1.86), and meeting sex partners online (aOR = 1.35; 95% CI: 1.03, 1.76). Recent genitourinary or rectal symptoms were not associated with infections.Conclusions: The overall and extragenital prevalence of NG and CT infections were high within this sample of young MSM without HIV in Hanoi. Testing limited to urethral specimens would have missed nearly three-quarters of CT and NG infections, supporting the need for routine testing at multiple anatomic sites

Prevalence, anatomic distribution, and correlates of Chlamydia trachomatis and Neisseria gonorrhoeae infections among a cohort of men who have sex with men in Hanoi, Vietnam.

Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) disproportionately affect men who have sex with men (MSM). Data on the prevalence, anatomical distribution, and correlates of NG and CT infections among MSM in Vietnam are limited.Between July 2017 and April 2019, MSM 16 years or older, without HIV were enrolled into an observational cohort study. Baseline data, including sociodemographics, sexual behavior, and HIV status were collected. NG and CT testing were performed on urine, rectal, and pharyngeal specimens. Multivariate logistic regression models identified factors associated with NG and CT infections at baseline.In total, 1489 participants underwent NG/CT testing. The median age was 22 years (IQR: 20 - 26). There were 424 (28.5%) NG or CT infections; 322 (21.6%) with CT and 173 (11.6%) with NG. Rectal infections were most common for CT (73.9%), while pharyngeal infections were most common for NG (70.5%). Independent risk factors for CT or NG infection included: ≥2 sex partners in the prior month (adjusted odds ratio [aOR] = 2.04; 95% CI: 1.44, 2.91), condomless anal sex (aOR = 1.44, 95% CI: 1.12, 1.86), and meeting sex partners online (aOR = 1.35; 95% CI: 1.03, 1.76). Recent genitourinary or rectal symptoms were not associated with infections.The overall and extragenital prevalence of NG and CT infections were high within this sample of young MSM without HIV in Hanoi. Testing limited to urethral specimens would have missed nearly three-quarters of CT and NG infections, supporting the need for routine testing at multiple anatomic sites

Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic

The prevalence of the coronavirus SARS-CoV-2 disease has resulted in the unprecedented collection of health data to support research. Historically, coordinating the collation of such datasets on a national scale has been challenging to execute for several reasons, including issues with data privacy, the lack of data reporting standards, interoperable technologies, and distribution methods. The coronavirus SARS-CoV-2 disease pandemic has highlighted the importance of collaboration between government bodies, healthcare institutions, academic researchers and commercial companies in overcoming these issues during times of urgency. The National COVID-19 Chest Imaging Database, led by NHSX, British Society of Thoracic Imaging, Royal Surrey NHS Foundation Trust and Faculty, is an example of such a national initiative. Here, we summarise the experiences and challenges of setting up the National COVID-19 Chest Imaging Database, and the implications for future ambitions of national data curation in medical imaging to advance the safe adoption of artificial intelligence in healthcare.</p