89 research outputs found
Stili di potere. Linguaggio politico, genere ed eros nella poesia imperiale romana
Lâarticolo offre alcune riflessioni sul rapporto tra potere, genere ed eros nella poesia imperiale romana: interpretando testi elegiaci ed epici di Ovidio e di Stazio, indaga il linguaggio della politica e del potere, il suo uso in relazione al genere e il suo rapporto con idee, linguaggio ed immagini, e codificazioni letterarie dellâamore. Si analizza in primo luogo una declinazione al femminile del linguaggio dellâambizione politica nelle Epistulae ex Ponto di Ovidio, nella Consolatio ad Helviam matrem di Seneca e nella Tebaide di Stazio (il modello di una donna ambitiosa pro â a favore di â un uomo amato, opposto al paradigma della donna ambitiosa per â per mezzo di â un congiunto); in secondo luogo, lâamore del potere attribuito alla dea dellâamore nella rappresentazione ovidiana di una Venere imperialista nelle Metamorfosi; infine, la matrice elegiaca del desiderio maschile di potere come desiderio erotico nella Tebaide, dove il ritratto platonico del tiranno come schiavo si trasforma nel servitium amoris del tiranno
Teseo, la clementia e la punizione dei tiranni: esemplaritĂ e pessimismo nel finale della Tebaide
Il ruolo di Teseo e della clementia nel finale della Tebaide si scontrano interpretazioni opposte del poema, in una polarizzazione che riproduce il dibattito critico sullâEneide. Letture sovversive e pessimistiche, o, al contrario, ottimistiche e celebrative, oscurano la complessitĂ di una chiusa in cui convivono esemplaritĂ e pessimismo, come nelle Supplici di Euripide. La Tebaide Ăš un discorso sul potere che inscrive in sĂ© la coscienza di una crisi; la frattura fra i primi undici libri e il dodicesimo spezza forma epica e discorso politico in due parti complementari e in tensione fra loro: allâepica del nefas si contrappone infine unâepica del vincitore, a una spedizione maledetta una guerra giusta, alla degenerazione del potere assoluto lâapparizione di una regalitĂ clemente; la proposta ideologica del finale sta al resto del poema come il De clementia sta alle tragedie di Seneca: rappresenta uno sforzo di ricostruzione dei valori su cui si fonda lâistituto imperiale. Ripensando in termini attuali lâopposizione fra Atene e Tebe nelle Supplici, Stazio trasforma il confronto euripideo fra democrazia e tirannide in un contrasto fra re e tiranno, fra clementia e inclementia regum, fra Teseo e Creonte. La costruzione del personaggio di Teseo mette in ombra la tradizione catulliana, selezionando i tratti che fanno dellâeroe nazionale ateniese un simbolo politico, adottato dai piĂč vari discorsi del potere. Lâassociazione di Teseo con la sovranitĂ clemente e con la punizione dei tiranni ha un precedente nellâHercules furens di Seneca. La moderazione di Teseo in battaglia Ăš illustrata con un paradigma animale (il leone mite con la preda) tradizionale nelle esortazioni alla clementia
Evaluation of solubility enhancement, antioxidant activity, and cytotoxicity studies of kynurenic acid loaded cyclodextrin nanosponge
α-cyclodextrin and α-cyclodextrin polymers as oxygen nanocarriers to limit hypoxia/reoxygenation injury: Implications from an in vitro model
The incidence of heart failure (HF) is increasing worldwide and myocardial infarction (MI), which follows ischemia and reperfusion (I/R), is often at the basis of HF development. Nanocarriers are interesting particles for their potential application in cardiovascular disease. Impaired drug delivery in ischemic disease is challenging. Cyclodextrin nanosponges (NS) can be considered innovative tools for improving oxygen delivery in a controlled manner. This study has developed new α-cyclodextrin-based formulations as oxygen nanocarriers such as native α-cyclodextrin (α-CD), branched α-cyclodextrin polymer (α-CD POLY), and α-cyclodextrin nanosponges (α-CD NS). The three different α-CD-based formulations were tested at 0.2, 2, and 20 ”g/mL to ascertain their capability to reduce cell mortality during hypoxia and reoxygenation (H/R) in vitro protocols. H9c2, a cardiomyoblast cell line, was exposed to normoxia (20% oxygen) or hypoxia (5% CO2 and 95% N2). The different formulations, applied before hypoxia, induced a significant reduction in cell mortality (in a range of 15% to 30%) when compared to samples devoid of oxygen. Moreover, their application at the beginning of reoxygenation induced a considerable reduction in cell death (12% to 20%). α-CD NS showed a marked efficacy in controlled oxygenation, which suggests an interesting potential for future medical application of polymer systems for MI treatment
'In Vitro', 'In Vivo' and 'In Silico' Investigation of the Anticancer Effectiveness of Oxygen-Loaded Chitosan-Shelled Nanodroplets as Potential Drug Vector
Assessment of antioxidant and drug releasing properties of cellulose fabrics functionalized with polymeric nanoparticles as potential biofunctional garments
Drug administration through skin raised a great interest as a not invasive and sustained method to
deliver active substances both at topical and systemic levels. Biofunctional textiles are a new class
of materials that combine conventional fabrics with advanced drug delivery systems in order to
develop a wearable functional biomaterial [1].
The present research aims to functionalize cellulosic fabrics (e.g. cotton and viscose) with
curcumin (CUR)-loaded polycaprolactone (PCL) nanoparticles (NPs) in order to assess their
potential as biofunctional garments.
The NPs were produced by the flash nanoprecipitation technique in a confined impinging jet mixer. Such technology was proven to be a simple and scalable approach to produce polymeric
nanoparticles; moreover it was successfully applied to curcumin encapsulation [2].
Nanoparticles were then characterized in terms of size and zeta potential by dynamic light
scattering (DLS), while the loading capacity (LC%) and encapsulation efficiency (EE%) were
measured by exploiting fluorescence spectroscopy.
Cotton and viscose fabrics were functionalized by imbibition with the NPs suspensions and the
effectiveness of the treatment was observed under wide-field fluorescence microscopy.
The release properties of the nanoparticles suspensions were studied in vitro in a multicompartment rotating cell, while the curcumin release from textile support was tested ex vivo in a Franz diffusion cell using porcine skin as membrane. Furthermore, the antioxidant activity of the
NPs and of the functionalized fabrics was measured by electron paramagnetic resonance
spectroscopy.
Curcumin loaded NPs were successfully prepared with good control of particle size and loading
capacity, high stability over several days and encapsulation efficiency higher than 99%.
Nanoparticles were successfully attached to the textiles material as evidenced by fluorescent
imaging. The prepared materials showed an improved antioxidant activity and the capability of
controlling curcumin release both in vivo and ex vivo.
The present research shows the possibility of producing biofunctional materials by simple and
scalable process and opens a route for a new generation of garments that can benefit people health
Histological and serological features of acute liver injury after SARS-CoV-2 vaccination
Codoni G, Kirchner T, Engel B, Villamil AM, Efe C, StÀttermayer AF, Weltzsch
JP, Sebode M, Bernsmeier C, Lleo A, Gevers TJ, KupÄinskas L, Castiella A, Pinazo J, De Martin E,
Bobis I, Sandahl TD, Pedica F, Invernizzi F, Del Poggio P, Bruns T, Kolev M, Semmo N, Bessone
F, Giguet B, Poggi G, Ueno M, Jang H, Elpek GĂ, Soylu NK, Cerny A, Wedemeyer H, Vergani D,
Mieli-Vergani G, Lucena MI, Andrade RJ, Zen Y, Taubert R, Beretta-Piccoli BT, Histological and
serological features of acute liver injury after SARS-CoV-2 vaccination, JHEP Reports (2022), doi:
https://doi.org/10.1016/j.jhepr.2022.100605.Liver injury with autoimmune features after vaccination against Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2) is increasingly reported. We investigated a large international cohort of patients with acute hepatitis arising after SARS-CoV-2 vaccination, focusing on histological and serological features
Un distico sospetto, Penelope e la âDoloniaâ. Nota a Ovidio, âHeroidesâ 1, 39-40
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