Sufficient conditions for the anti-Zeno effect

The ideal anti-Zeno effect means that a perpetual observation leads to an immediate disappearance of the unstable system. We present a straightforward way to derive sufficient conditions under which such a situation occurs expressed in terms of the decaying states and spectral properties of the Hamiltonian. They show, in particular, that the gap between Zeno and anti-Zeno effects is in fact very narrow.Comment: LatEx2e, 9 pages; a revised text, to appear in J. Phys. A: Math. Ge

Stability and instability in parametric resonance and quantum Zeno effect

A quantum mechanical version of a classical inverted pendulum is analyzed. The stabilization of the classical motion is reflected in the bounded evolution of the quantum mechanical operators in the Heisenberg picture. Interesting links with the quantum Zeno effect are discussed.Comment: 6 pages, 3 figure

Purification through Zeno-like Measurements

A series of frequent measurements on a quantum system (Zeno-like measurements) is shown to result in the ``purification'' of another quantum system in interaction with the former. Even though the measurements are performed on the former system, their effect drives the latter into a pure state, irrespectively of its initial (mixed) state, provided certain conditions are satisfied.Comment: REVTeX4, 4 pages, 1 figure; to be published in Phys. Rev. Lett. (2003

Prospective Biorepository Participants' Perspectives on Access to Research Results

Disclosure of individual research results to research participants has been the subject of professional guidelines as well as scholarly commentary, yet controversy remains. To gather data on participant perspectives, we interviewed 40 individuals from the Durham, North Carolina area about a biorepository consent form and conducted an in-depth analysis of responses to a series of questions concerning access to research results. Cross-cutting themes emerged about (1) the nature of research; (2) the nature of research results; (3) expectations concerning access to research results; and (4) practical issues in providing access to research results. Our findings highlight the importance for sound policy development of soliciting stakeholder input, and exploring the complexities behind their evaluations

The decay law can have an irregular character

Within a well-known decay model describing a particle confined initially within a spherical $\delta$ potential shell, we consider the situation when the undecayed state has an unusual energy distribution decaying slowly as $k\to\infty$; the simplest example corresponds to a wave function constant within the shell. We show that the non-decay probability as a function of time behaves then in a highly irregular, most likely fractal way.Comment: 4 pages, 3 eps figure

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

In Saccharomyces cerevisiae, chemical or genetic inhibition of proteasome activity induces new proteasome synthesis promoted by the transcription factor RPN4. This ensures that proteasome activity is matched to demand. This transcriptional feedback loop is conserved in mammals, but its molecular basis is not understood. Here, we report that nuclear factor erythroid-derived 2-related factor 1 (Nrf1), a transcription factor of the cap “n” collar basic leucine zipper family, but not the related Nrf2, is necessary for induced proteasome gene transcription in mouse embryonic fibroblasts (MEFs). Promoter-reporter assays revealed the importance of antioxidant response elements in Nrf1-mediated upregulation of proteasome subunit genes. Nrf1^(−/−) MEFs were impaired in the recovery of proteasome activity after transient treatment with the covalent proteasome inhibitor YU101, and knockdown of Nrf1 in human cancer cells enhanced cell killing by YU101. Taken together, our results suggest that Nrf1-mediated proteasome homeostasis could be an attractive target for therapeutic intervention in cancer

Survival law in a potential model

The radial equation of a simple potential model has long been known to yield an exponential decay law in lowest order (Breit-Wigner) approximation. We demonstrate that if the calculation is extended to fourth order the decay law exhibits the quantum Zeno effect. This model has further been studied numerically to characterize the extra exponential time parameter which compliments the lifetime. We also investigate the inverse Zeno effect.Comment: 16 pages, 2 tables, 3 figures, AMS-Te

Quantum Zeno effect in a probed downconversion process

The distorsion of a spontaneous downconvertion process caused by an auxiliary mode coupled to the idler wave is analyzed. In general, a strong coupling with the auxiliary mode tends to hinder the downconversion in the nonlinear medium. On the other hand, provided that the evolution is disturbed by the presence of a phase mismatch, the coupling may increase the speed of downconversion. These effects are interpreted as being manifestations of quantum Zeno or anti-Zeno effects, respectively, and they are understood by using the dressed modes picture of the device. The possibility of using the coupling as a nontrivial phase--matching technique is pointed out.Comment: 11 pages, 4 figure

Certificates of Confidentiality: Protecting Human Subject Research Data in Law and Practice

The federal Certificate of Confidentiality plays an important role in research on sensitive topics by authorizing researchers to refuse to disclose identifiable research data in response to subpoenas in any legal setting. However, there is little known about how effective Certificates are in practice. This article draws on our legal and empirical research on this topic to fill this information gap. It includes a description of the purpose of Certificates, their legislative and regulatory history, and a summary of the few reported and unreported cases that have dealt with Certificates. In addition, we outline other statutory confidentiality protections, compare them to the Certificate\u27s protections, and analyze some of the vulnerabilities of a Certificate\u27s protections. This analysis allows us to make specific recommendations for strengthening the protections afforded to research data

Quantum Zeno subspaces

The quantum Zeno effect is recast in terms of an adiabatic theorem when the measurement is described as the dynamical coupling to another quantum system that plays the role of apparatus. A few significant examples are proposed and their practical relevance discussed. We also focus on decoherence-free subspaces.Comment: 5 pages, 1 figure, to be published in Phys. Rev. Let