Financial Market Update

Am 22. und 23. März 2007 findet die CESifo International Spring Conference statt. Hauptthema der Veranstaltung ist die Verfassung der Finanzmärkte in einem Umfeld sich abschwächenden weltwirtschaftlichen Wachstums. Was sind die Risikopotentiale nach Jahren ohne nennenswerte Krisen angesichts hoher Liquidität und gestiegener Risikobereitschaft der Investoren? Diesem Thema widmet sich schwerpunktmäßig Axel Bertuch-Samuels, Stellvertretender Direktor der Abteilung Geld- und Kapitalmärkte des Internationalen Währungsfonds in Washington. In seinem Vortrag mit dem Titel "Challenges for Financial Markets in Slowing Global Growth?" wird er Überlegungen zur Aktualisierung des Financial Market Update im April 2007 präsentieren

The C-terminal extension unique to the long isoform of the shelterin component TIN2 enhances its interaction with TRF2 in a phosphorylation- and dyskeratosis congenita-cluster-dependent fashion

TIN2 is central to the shelterin complex, linking the telomeric proteins TRF1 and TRF2 with TPP1/POT1. Mutations in TINF2, which encodes TIN2, that are found in dyskeratosis congenita (DC) result in very short telomeres and cluster in a region shared by the two TIN2 isoforms, TIN2S (short) and TIN2L (long). Here we show that TIN2L, but not TIN2S, is phosphorylated. TRF2 interacts more with TIN2L than TIN2S, and both the DC-cluster and phosphorylation promote this enhanced interaction. The binding of TIN2L, but not TIN2S, is affected by TRF2-F120, which is also required for TRF2's interaction with end processing factors such as Apollo. Conversely, TRF1 interacts more with TIN2S than with TIN2L. A DC-associated mutation further reduces TIN2L-TRF1, but not TIN2S-TRF1, interaction. Cells overexpressing TIN2L or phosphomimetic-TIN2L are permissive to telomere elongation, whereas cells overexpressing TIN2S or phosphodead-TIN2L are not. Telomere lengths are unchanged in cell lines in which TIN2L expression has been eliminated by CRISPR/Cas9-mediated mutation. These results indicate that TIN2 isoforms are biochemically and functionally distinguishable, and that shelterin composition could be fundamentally altered in patients with TINF2 mutations

Modeling Growth and Telomere Dynamics in Saccharomyces Cerevisiae

A general branching process is proposed to model a population of cells of the yeast Saccharomyces cerevisiae following loss of telomerase. Previously published experimental data indicate that a population of telomerase-deficient cells regain exponential growth after a period of slowing due to critical telomere shortening. The explanation for this phenomenon is that some cells engage telomerase-independent pathways to maintain telomeres that allow them to become “survivors.” Our model takes into account random variation in individual cell cycle times, telomere length, finite lifespan of mother cells, and survivorship. We identify and estimate crucial parameters such as the probability of an individual cell becoming a survivor, and compare our model predictions to experimental data

Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106711/1/pbc24875.pd

Forschungssoftware in Bibliotheken

Software is increasingly acknowledged as valid research output. Academic libraries adapt to this change to become research software-ready. Software publication and citation are key areas in this endeavor. We present and discuss the current state of the practice of software publication and software citation, and discuss four areas of activity that libraries engage in: (1) technical infrastructure, (2) training and support, (3) software management and curation, (4) policies.Software wird zunehmend als gültiges Forschungsergebnis anerkannt. Wissenschaftliche Bibliotheken passen sich diesem Wandel an, um für Forschungssoftware gerüstet zu sein. Softwarepublikation und -zitierung sind hierbei Schlüsselbereiche. Wir präsentieren und diskutieren hier den aktuellen Praxisstand und heben vier Bereiche hervor, in denen Bibliotheken aktiv werden können, um für Forschungssoftware gerüstet zu sein: (1) technische Infrastruktur, (2) Schulung und Support, (3) Management und Kuratierung von Software, (4) Richtlinien.Peer Reviewe

Radiation characteristics of mushroom-like PPW LWAs: Analysis and experimental verification

The radiation characteristics of mushroom-like parallel-plate waveguide composite right/left-handed leaky-wave antennas (PPW CRLH LWAs) are presented, analyzed, mathematically modeled, and experimentally verified. For this purpose, a frequency-dependent formulation, based on a dispersive circuital model of the antenna, is proposed. The formulation inherently takes into account the mutual coupling between the slots, radiation losses, reactive fields, and the fluctuations of the radiated power with frequency. Very good agreement in the 1-D and 2-D radiation patterns obtained by the proposed formulation and the measured results from a PPW CRLH LWA prototype is found, validating both the antenna radiating properties and the proposed theory

Advancing Software Citation Implementation (Software Citation Workshop 2022)

Software is foundationally important to scientific and social progress, however, traditional acknowledgment of the use of others' work has not adapted in step with the rapid development and use of software in research. This report outlines a series of collaborative discussions that brought together an international group of stakeholders and experts representing many communities, forms of labor, and expertise. Participants addressed specific challenges about software citation that have so far gone unresolved. The discussions took place in summer 2022 both online and in-person and involved a total of 51 participants. The activities described in this paper were intended to identify and prioritize specific software citation problems, develop (potential) interventions, and lay out a series of mutually supporting approaches to address them. The outcomes of this report will be useful for the GLAM (Galleries, Libraries, Archives, Museums) community, repository managers and curators, research software developers, and publishers

A modal-based iterative circuit model for the analysis of CRLH leaky-wave antennas comprising periodically loaded PPW

A novel modal-based iterative circuit model is described for the calculation of the complex propagation constant of mushroom-like parallel-plate composite right/left handed leaky-wave antennas (PPW CRLH LWAs). The conventional lossless CRLH unit cell circuit is modified in order to consider the electromagnetic coupling to free space through a slot. For this purpose, a slot equivalent radiative structure, based on phased-array theory, is analyzed using a mode matching approach combined with Floquet's theorem. A direct correspondence between lumped elements and this radiative structure is found, leading to a frequency-dependent unit cell circuit model. A quickly converging iterative algorithm is then employed to determine the final element values of the unit cell. The proposed method is accurate, and it takes into account the structure physical dimensions. It also allows to obtain a balanced CRLH unit cell design without requiring any full-wave simulation, is several orders of magnitude faster than full-wave simulations, and provides a deep insight into the physics of the antenna radiation mechanism.Ministerio de Educación y Ciencia, Ref. TEC2010-21520-C04-0