Pharmacokinetics, safety and efficacy from randomized controlled trials of 1 and 2 mg nicotine bitartrate lozenges (Nicotinell)-3

<p><b>Copyright information:</b></p><p>Taken from "Pharmacokinetics, safety and efficacy from randomized controlled trials of 1 and 2 mg nicotine bitartrate lozenges (Nicotinell)"</p><p>http://www.biomedcentral.com/1472-6904/7/11</p><p>BMC Clinical Pharmacology 2007;7():11-11.</p><p>Published online 8 Oct 2007</p><p>PMCID:PMC2194660.</p><p></p>otine lozenges for abrupt quitting over the first 6 months of the French efficacy trial

Pharmacokinetics, safety and efficacy from randomized controlled trials of 1 and 2 mg nicotine bitartrate lozenges (Nicotinell)-0

<p><b>Copyright information:</b></p><p>Taken from "Pharmacokinetics, safety and efficacy from randomized controlled trials of 1 and 2 mg nicotine bitartrate lozenges (Nicotinell)"</p><p>http://www.biomedcentral.com/1472-6904/7/11</p><p>BMC Clinical Pharmacology 2007;7():11-11.</p><p>Published online 8 Oct 2007</p><p>PMCID:PMC2194660.</p><p></p>drawn before administration of each single dose (unconnected data points). Consecutive blood samples (connected data points) were drawn after administration of dose 1 (t = 0) and dose 12 (t = 11 h). The insert shows a blood nicotine peak after dosing at steady state obtained with blood draws after dose 12 (11–12 h)

Pharmacokinetics, safety and efficacy from randomized controlled trials of 1 and 2 mg nicotine bitartrate lozenges (Nicotinell)-1

<p><b>Copyright information:</b></p><p>Taken from "Pharmacokinetics, safety and efficacy from randomized controlled trials of 1 and 2 mg nicotine bitartrate lozenges (Nicotinell)"</p><p>http://www.biomedcentral.com/1472-6904/7/11</p><p>BMC Clinical Pharmacology 2007;7():11-11.</p><p>Published online 8 Oct 2007</p><p>PMCID:PMC2194660.</p><p></p>nicotine lozenge (unconnected data points). Consecutive blood samples (connected data points) were drawn after administration of dose 12 (t = 11 h), and the derived data points are connected. Plasma concentrations obtained with 1 mg lozenges were doubled for ease of comparison

Pharmacokinetics, safety and efficacy from randomized controlled trials of 1 and 2 mg nicotine bitartrate lozenges (Nicotinell)-2

<p><b>Copyright information:</b></p><p>Taken from "Pharmacokinetics, safety and efficacy from randomized controlled trials of 1 and 2 mg nicotine bitartrate lozenges (Nicotinell)"</p><p>http://www.biomedcentral.com/1472-6904/7/11</p><p>BMC Clinical Pharmacology 2007;7():11-11.</p><p>Published online 8 Oct 2007</p><p>PMCID:PMC2194660.</p><p></p>mg nicotine lozenge or 4 mg nicotine gum (unconnected data points). Consecutive blood samples (connected data points) were drawn after administration of dose 12 (t = 11 h)

Nicotine and PM2.5 concentrations (µg/m³) by season, area and smoking regulation (paired samples). IMPASHS study, 2009–2011.

a<p>Wilcoxon test for comparison of medians from indoor/outdoor areas.</p>b<p>Mann-Whitney U-test for comparison of medians from areas where smoking was allowed/banned.</p><p>LQ: Limit of quantification.</p>*<p>p<0.05.</p>**<p>p<0.006 (significance level of 0.05 adjusted for Bonferroni correction for 8 comparisons).</p

Nicotine and PM2.5 concentrations (µg/m³) by type of outdoor area (paired samples). IMPASHS study, 2009–2010.

a<p>Wilcoxon test for comparison of medians from indoor/outdoor areas.</p>b<p>Mann-Whitney U-test for comparison of medians from areas where smoking was allowed/banned.</p>c<p>Open area was defined as an outdoor area with no roof and no surrounding walls.</p>d<p>Semi-closed was defined as an outdoor area with at least one wall or roof.</p>*<p>p<0.05.</p>**<p>p<0.006 (significance level of 0.05 adjusted for Bonferroni correction for 8 comparisons).</p

Nicotine and PM2.5 concentrations (µg/m³) by type of venue, area and smoking regulation. IMPASHS study, 2009–2011.

a<p>Wilcoxon test for comparison of medians from indoor/outdoor areas.</p>b<p>Mann-Whitney U-test for comparison of medians from areas where smoking was allowed/banned.</p>*<p>p<0.05.</p>**<p>p<0.004 (significance level of 0.05 adjusted for Bonferroni correction for 12 comparisons).</p