A meta-analysis on progressive atrophy in intractable temporal lobe epilepsy Time is brain?

Objective: It remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is associated with cumulative brain damage, with no expert consensus and no quantitative syntheses of the available evidence. Methods: We conducted a systematic review and meta-analysis of MRI studies on progressive atrophy, searching PubMed and Ovid MEDLINE databases for cross-sectional and longitudinal quantitative MRI studies on drug-resistant TLE. Results: We screened 2,976 records and assessed eligibility of 248 full-text articles. Forty-two articles met the inclusion criteria for quantitative evaluation. We observed a predominance of cross-sectional studies, use of different clinical indices of progression, and high heterogeneity in age-control procedures. Meta-analysis of 18/1 cross-sectional/longitudinal studies on hippocampal atrophy (n 5 979 patients) yielded a pooled effect size of r 5 20.42 for ipsilateral atrophy related to epilepsy duration (95% confidence interval [CI] 20.51 to 20.32; p , 0.0001; I 2 5 65.22%) and r 5 20.35 related to seizure frequency (95% CI 20.47 to 20.22; p , 0.0001; I 2 5 61.97%). Sensitivity analyses did not change the results. Narrative synthesis of 25/3 crosssectional/longitudinal studies on whole brain atrophy (n 5 1,504 patients) indicated that .80% of articles reported duration-related progression in extratemporal cortical and subcortical regions. Detailed analysis of study design features yielded low to moderate levels of evidence for progressive atrophy across studies, mainly due to dominance of cross-sectional over longitudinal investigations, use of diverse measures of seizure estimates, and absence of consistent age control procedures. Conclusions: While the neuroimaging literature is overall suggestive of progressive atrophy in drug-resistant TLE, published studies have employed rather weak designs to directly demonstrate it. Longitudinal multicohort studies are needed to unequivocally differentiate aging from disease progression

Grids of stellar models. VIII. From 0.4 to 1.0 Msun at Z=0.020 and Z=0.001, with the MHD equation of state

We present stellar evolutionary models covering the mass range from 0.4 to 1 Msun calculated for metallicities Z=0.020 and 0.001 with the MHD equation of state (Hummer & Mihalas, 1988; Mihalas et al. 1988; D\"appen et al. 1988). A parallel calculation using the OPAL (Rogers et al. 1996) equation of state has been made to demonstrate the adequacy of the MHD equation of state in the range of 1.0 to 0.8 Msun (the lower end of the OPAL tables). Below, down to 0.4 Msun, we have justified the use of the MHD equation of state by theoretical arguments and the findings of Chabrier & Baraffe (1997). We use the radiative opacities by Iglesias & Rogers (1996), completed with the atomic and molecular opacities by Alexander & Fergusson (1994). We follow the evolution from the Hayashi fully convective configuration up to the red giant tip for the most massive stars, and up to an age of 20 Gyr for the less massive ones. We compare our solar-metallicity models with recent models computed by other groups and with observations. The present stellar models complete the set of grids computed with the same up-to-date input physics by the Geneva group [Z=0.020 and 0.001, Schaller et al. (1992), Bernasconi (1996), and Charbonnel et al. (1996); Z=0.008, Schaerer et al. (1992); Z=0.004, Charbonnel et al. (1993); Z=0.040, Schaerer et al. (1993); Z=0.10, Mowlavi et al. (1998); enhanced mass loss rate evolutionary tracks, Meynet et al. (1994)].Comment: Accepted for publication in A&A Supplement Serie

A complete characterization of plateaued Boolean functions in terms of their Cayley graphs

In this paper we find a complete characterization of plateaued Boolean functions in terms of the associated Cayley graphs. Precisely, we show that a Boolean function $f$ is $s$-plateaued (of weight $=2^{(n+s-2)/2}$) if and only if the associated Cayley graph is a complete bipartite graph between the support of $f$ and its complement (hence the graph is strongly regular of parameters $e=0,d=2^{(n+s-2)/2}$). Moreover, a Boolean function $f$ is $s$-plateaued (of weight $\neq 2^{(n+s-2)/2}$) if and only if the associated Cayley graph is strongly $3$-walk-regular (and also strongly $\ell$-walk-regular, for all odd $\ell\geq 3$) with some explicitly given parameters.Comment: 7 pages, 1 figure, Proceedings of Africacrypt 201

Developmental MRI markers cosegregate juvenile patients with myoclonic epilepsy and their healthy siblings

OBJECTIVE: MRI studies of genetic generalized epilepsies have mainly described group-level changes between patients and healthy controls. To determine the endophenotypic potential of structural MRI in juvenile myoclonic epilepsy (JME), we examined MRI-based cortical morphologic markers in patients and their healthy siblings. METHODS: In this prospective, cross-sectional study, we obtained 3T MRI in patients with JME, siblings, and controls. We mapped sulco-gyral complexity and surface area, morphologic markers of brain development, and cortical thickness. Furthermore, we calculated mean geodesic distance, a surrogate marker of cortico-cortical connectivity. RESULTS: Compared to controls, patients and siblings showed increased folding complexity and surface area in prefrontal and cingulate cortices. In these regions, they also displayed abnormally increased geodesic distance, suggesting network isolation and decreased efficiency, with strongest effects for limbic, fronto-parietal, and dorsal-attention networks. In areas of findings overlap, we observed strong patient-sibling correlations. Conversely, neocortical thinning was present in patients only and related to disease duration. Patients showed subtle impairment in mental flexibility, a frontal lobe function test, as well as deficits in naming and design learning. Siblings' performance fell between patients and controls. CONCLUSION: MRI markers of brain development and connectivity are likely heritable and may thus serve as endophenotypes. The topography of morphologic anomalies and their abnormal structural network integration likely explains cognitive impairments in patients with JME and their siblings. By contrast, cortical atrophy likely represents a marker of disease

On the correlation between Ca and Halpha solar emission and consequences for stellar activity observations

The correlation between Ca and Halpha chromospheric emission, known to be positive in the solar case, has been found to vary between -1 and 1 for other stars. Our objective is to understand the factors influencing this correlation in the solar case, and then to extrapolate our interpretation to other stars. We characterize the correlation between both types of emission in the solar case for different time scales. Then we determine the filling factors due to plages and filaments, and reconstruct the Ca and Halpha emission to test different physical conditions in terms of plage and filament contrasts. We have been able to precisely determine the correlation in the solar case as a function of the cycle phase. We interpret the results as reflecting the balance between the emission in plages and the absorption in filaments. We found that correlations close to zero or slightly negative can be obtained when considering the same spatio-temporal distribution of plages and filaments than on the sun but with greater contrast. However, with that assumption, correlations close to -1 cannot be obtained for example. Stars with a very low Halpha contrast in plages and filaments well correlated with plages could produce a correlation close to -1. This study opens new ways to study stellar activity, and provides a new diagnosis that will ultimately help to understand the magnetic configuration of stars other than the sun.Comment: 10 pages, 13 figures, accepted in Astronomy and Astrophysic

Automatic detection of limb prominences in 304 A EUV images

A new algorithm for automatic detection of prominences on the solar limb in 304 A EUV images is presented, and results of its application to SOHO/EIT data discussed. The detection is based on the method of moments combined with a classifier analysis aimed at discriminating between limb prominences, active regions, and the quiet corona. This classifier analysis is based on a Support Vector Machine (SVM). Using a set of 12 moments of the radial intensity profiles, the algorithm performs well in discriminating between the above three categories of limb structures, with a misclassification rate of 7%. Pixels detected as belonging to a prominence are then used as starting point to reconstruct the whole prominence by morphological image processing techniques. It is planned that a catalogue of limb prominences identified in SOHO and STEREO data using this method will be made publicly available to the scientific community

ENHANCEMENT OF MODE I FRACTURE TOUGHNESS OF ADHESIVELY BONDED SECONDARY JOINTS USING LAYUP PATTERNING OF CFRP

This work aims to analyse the influence of the CFRP layup patterning on the crack path of composite bonded joints and evaluate its effect on the mode I fracture toughness. An experimental program has been performed using Double Cantilever Beam tests with three different CFRP layup patterning and two adhesives. In addition, a finite element analysis was also implemented to further identify different damage mechanisms during the tests. The outcome shows that different substrate CFRP layup patterning results in distinct crack onsets and propagation paths during the tests, also influenced by the type of adhesive used. Furthermore, an enhancement of around 25% in the joint's onset fracture toughness was observed with the layup patterning compared to a reference joint (with unidirectional layup). Thus, the substrate's patterning morphology seems to be a promising method to increase the mode I fracture toughness of the studied secondary joints