El plan andaluz de atención a las altas capacidades intelectuales: panorama actual y perspectivas de futuro

En nuestro trabajo reconocemos la importancia de promulgar y desarrollar un Plan específico para detectar alumnos y alumnas de altas capacidades, de cara darles la respuesta educativa más adecuada. Analizamos las características del Plan promulgado y puesto en marcha por la Junta de Andalucía, tratando de ver de modo crítico y constructivo sus ventajas y limitaciones. Finalmente, se hacen algunas sugerencias para mejorar las limitaciones detectadas.In our work we recognize the importance of enacting and develop a specific plan to detect high ability students, facing them to the most appropriate educational response. We analyze the characteristics of the issued implemented by the Government of Andalusia, trying to see, in a critical and constructive way, its advantages and limitations. Finally, some suggestions are made to improve the identified limitations.peerReviewe

Persistent Pulmonary Hypertension in Corrected Valvular Heart Disease: Hemodynamic Insights and Long‐Term Survival

Insuficiència cardíaca; Hipertensió pulmonar; Malaltia valvular cardíacaInsuficiencia cardiaca; Hipertensión pulmonar; Enfermedad valvular cardíacaHeart failure; Pulmonary hypertension; Valvular heart diseaseBackground The determinants and consequences of pulmonary hypertension after successfully corrected valvular heart disease remain poorly understood. We aim to clarify the hemodynamic bases and risk factors for mortality in patients with this condition. Methods and Results We analyzed long‐term follow‐up data of 222 patients with pulmonary hypertension and valvular heart disease successfully corrected at least 1 year before enrollment who had undergone comprehensive hemodynamic and imaging characterization as per the SIOVAC (Sildenafil for Improving Outcomes After Valvular Correction) clinical trial. Median (interquartile range) mean pulmonary pressure was 37 mm Hg (32–44 mm Hg) and pulmonary artery wedge pressure was 23 mm Hg (18–26 mm Hg). Most patients were classified either as having combined precapillary and postcapillary or isolated postcapillary pulmonary hypertension. After a median follow‐up of 4.5 years, 91 deaths accounted for 4.21 higher‐than‐expected mortality in the age‐matched population. Risk factors for mortality were male sex, older age, diabetes mellitus, World Health Organization functional class III and higher pulmonary vascular resistance—either measured by catheterization or approximated from ultrasound data. Higher pulmonary vascular resistance was related to diabetes mellitus and smaller residual aortic and mitral valve areas. In turn, the latter correlated with prosthetic nominal size. Six‐month changes in the composite clinical score and in the 6‐minute walk test distance were related to survival. Conclusions Persistent valvular heart disease–pulmonary hypertension is an ominous disease that is almost universally associated with elevated pulmonary artery wedge pressure. Pulmonary vascular resistance is a major determinant of mortality in this condition and is related to diabetes mellitus and the residual effective area of the corrected valve. These findings have important implications for individualizing valve correction procedures.This study was funded by the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Spain, the European Union–European Regional Development Fund (EC07/90772 and PI19/00649), and the Consorcio de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)

Organizaciones supramoleculares de moléculas dendríticas con estructuras tipo "Bent-Core"

Resumen del póster presentado a la 6ª Jornada de Jóvenes Investigadores en Física y Química de Aragón celebrada en Zaragoza el 20 de noviembre de 2014.Beca de Colaboración del MEC y Beca de Iniciación a la Investigación del INA (A. M. B-S), Beca JAE-Predoc (M. M-A), Beca FPI (A. C.). Grupo de Cristales Líquidos y Polímeros: proyectos MAT2012-38538-CO3-01 y CTQ2012-35692 (MINECO-FEDER) y E04 (Gobierno de Aragón).Peer reviewe

Striking Variability in the Post-Reproductive Movements of Spanish Red Kites (Milvus milvus): Three Strategies, Sex Differences, and Changes over Time

It was assumed that the Spanish breeding population of the red kite (Milvus milvus) was resident, hence their movements were restricted to their breeding area for their entire lifecycle. However, recent observations indicated that the post-reproductive strategies of the red kite in Spain are more diverse. We tagged 47 breeding adult red kites in Spain and analyzed their movements during the post-reproductive period (July–February). We found three strategies in the population: migration (10%), sedentarism (70%), and sedentarism with post-reproductive movements (20%), based on seasonality and other movement parameters. Sedentarism with post-reproductive movements was a very variable strategy that involved all-direction wandering movements far away from the nest (up to 589 km) after breeding season, and then a returned journey toward the starting point in time for the next breeding season. Our results also suggest that sedentarism with post-reproductive movements is much more common in females than males. Furthermore, 17% of the individuals changed their strategy over the years. This study highlights the great individual variability and plasticity of the red kite and allows for a better understanding of spatial ecology in opportunistic raptors

Instructional Changes Adopted for an Engineering Course: Cluster Analysis on Academic Failure

As first-year students come from diverse backgrounds, basic skills should be accessible to everyone as soon as possible. Transferring such skills to these students is challenging, especially in highly technical courses. Ensuring that essential knowledge is acquired quickly promotes the student’s self-esteem and may positively influence failure rates. Metaphors can help do this. Metaphors are used to understand the unknown. This paper shows how we made a turn in student learning at the University of Almeria. Our hypothesis assumed that metaphors accelerate the acquisition of basic knowledge so that other skills built on that foundation are easily learned. With these goals in mind, we changed the way we teach by using metaphors and abstract concepts in a computer organisation course, a technical course in the first year of an information technology engineering degree. Cluster analysis of the data on collective student performance after this methodological change clearly identified two distinct groups. These two groups perfectly matched the before and after scenarios of the use of metaphors. The study was conducted during 11 academic years (2002/2003 to 2012/2013). The 475 observations made during this period illustrate the usefulness of this change in teaching and learning, shifting from a propositional teaching/learning model to a more dynamic model based on metaphors and abstractions. Data covering the whole period showed favourable evolution of student achievement and reduced failure rates, not only in this course, but also in many of the following more advanced courses.The paper is structured in five sections. The first gives an introduction, the second describes the methodology. The third section describes the sample and the study carried out. The fourth section presents the results and, finally, the fifth section discusses the main conclusions

Can the exercise mode determine lipid profile improvements in obese patients?

Influencia del modo de ejercicio sobre el perfil lipídic

Preparation of cellulose aerogels from ionic liquid solutions for supercritical impregnation of phytol

Producción CientíficaThe use of natural polysaccharides is especially attractive to the pharmaceutical industry because of their stability, availability, renewability and low toxicity. In this study, cellulose aerogels obtained from cellulose/ionic liquid solutions were prepared by supercritical drying with surface areas ranged from 154 to 434 m2 g−1, pore volume from 0.3 to 2.4 cm3 g−1 and pore diameter from 7.9 to 34 nm. Drug loading capacity was investigated by impregnating phytol as model compound into the aerogels, using supercritical CO2 at 100 bar, 40 °C and mass ratio of phytol per gram of aerogel 10:1. The quantity of drug present is consistent in each aerogel. The aerogel prepared from 2 wt% cellulose in [Emim][DEP] solution showed the highest loading capacity. The high amount of drug loaded (approx 50% w/w) in the cellulose aerogels prepared from ionic liquid solutions shows their potential uses in the pharmaceutical or medical industry.2019-07-252019-07-25Junta de Castilla y León VA295U14Marie Curie Program. Project DoHipMinisterio de Economía. Programa Ramon y Cajal, RyC RYC-2013-13976MOE (Ministry of Education of Malaysia

Delivery of miR-200c-3p Using Tumor-Targeted Mesoporous Silica Nanoparticles for Breast Cancer Therapy

[EN] Despite advancesin breast cancer treatment, it remainsthe leadingcause of cancer-related death in women worldwide. In this context,microRNAs have emerged as potential therapeutic targets but stillpresent some limitations for in vivo applications.Particularly, miR-200c-3p is a well-known tumor suppressor microRNAthat inhibits tumor progression and metastasis in breast cancer throughdownregulating ZEB1 and ZEB2. Basedon the above, we describe the design and validation of a nanodeviceusing mesoporous silica nanoparticles for miR-200c-3p delivery forbreast cancer treatment. We demonstrate the biocompatibility of thesynthesized nanodevices as well as their ability to escape from endosomes/lysosomesand inhibit tumorigenesis, invasion, migration, and proliferationof tumor cells in vitro. Moreover, tumor targetingand effective delivery of miR-200c-3p from the nanoparticles in vivo are confirmed in an orthotopic breast cancer mousemodel, and the therapeutic efficacy is also evidenced by a decreasein tumor size and lung metastasis, while showing no signs of toxicity.Overall, our results provide evidence that miR-200c-3p-loaded nanoparticlesare a potential strategy for breast cancer therapy and a safe andeffective system for tumor-targeted delivery of microRNAs.This research was supported by project PID2021-126304OB-C41 funded by MCIN/AEI/10.13039/501100011033/ and by European Regional Development Fund A way of doing Europe. Also, this study forms part of the Advanced Materials program (MFA/2022/049) and was supported by MCIN with funding from European Union NextGeneration EU(PRTR-C17.I1) and by Generalitat Valenciana. This study was also supported by Generalitat Valenciana (CIPROM/2021/007). This research was also supported by CIBER Consorcio Centro de Investigación Biomédica en Red CIBER-BBN(CB07/01/2012), CIBERONC(CB16/12/00481), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación. This work was also supported by Spanish Government and cofinanced by FEDER Funds (PI18/01219, PI21/01351) .I.G.-C. was funded by Margarita Salas post doctoral grant (European Union-Nextgeneration EU). A.A.-A. and A.L. were funded by Asociación Española Contra el Cancer.J.F.B. was funded by Instituto de Salud Carlos III and the European Social Fund for the financial support 'Sara Borrell' (CD19/00038). V.C.-N. was funded by Ministerio de Ciencia e Innovacio¿n (FPU grant), and J.M.C. was funded by Sociedad Española de Oncología Médica (Río Hortega-SEOM)Garrido-Cano, I.; Adam-Artigues, A.; Lameirinhas, A.; Blandez, JF.; Candela-Noguera, V.; Lluch, A.; Bermejo, B.... (2023). Delivery of miR-200c-3p Using Tumor-Targeted Mesoporous Silica Nanoparticles for Breast Cancer Therapy. ACS Applied Materials & Interfaces. 15(32):38323-38334. https://doi.org/10.1021/acsami.3c075413832338334153