Evolving drug therapies for chronic hepatitis C: Immunomodulation and beyond

Chronic hepatitis C infection is a major health problem and a leading cause of chronic liver disease. The hepatitis C virus was discovered in 1989 (1, 2). The virus is a small, enveloped, single-stranded, positive sense RNA virus and is a member of the hepacivirus genus in the family Flaviridae (3). Six major genotypes have been identified with several subtypes within each genotype (4). Viral replication occurs predominantly within hepatocytes in the liver but there is some evidence that it might also replicate outside the liver, in peripheral blood mononuclear cells, in lymphoid cells and in neurons (5, 6). Chronic hepatitis C infection can cause cirrhosis, digestive hemorrhage, liver failure and liver cancer

Spin-Orbit-Induced Kondo Size Effect in Thin Films with 5/2-spin Impurities

Recently, for spin $S=5/2$ impurities quite different size dependence of the Kondo contribution to the resistivity was found experimentally than for S=2. Therefore previous calculation about the effect of the spin-orbit-induced magnetic anisotropy on the Kondo amplitude of the resistivity is extended to the case of $S=5/2$ impurity spin which differs from the integer spin case as the ground state is degenerated. In this case the Kondo contribution remains finite when the sample size goes to zero and the thickness dependence in the Kondo resistivity is much weaker for Cu(Mn). The behavior of the Kondo coefficient as a function of the thickness depends on the Kondo temperature, that is somewhat stronger for larger $T_K$. Comparing our results with a recent experiment in thin Cu(Mn) films, we find a good agreement.Comment: 8 pages, ReVTeX + 4 figures (Postscript

Can lepton flavor violating interactions explain the LSND results?

If the atmospheric and the solar neutrino problem are both explained by neutrino oscillations, and if there are only three light neutrinos, then all mass-squared differences between the neutrinos are known. In such a case, existing terrestrial neutrino oscillation experiments cannot be significantly affected by neutrino oscillations, but, in principle there could be an anomaly in the neutrino flux due to new neutrino interactions. We discuss how a non-standard muon decay $\mu^+ \to e^+ \bar\nu_e \nu_\ell$ would modify the neutrino production processes of these experiments. Since $SU(2)_L$ violation is small for New Physics above the weak scale one can use related flavor-violating charged lepton processes to constrain these decays in a model independent way. We show that the upper bounds on $\mu \to 3e$, muonium-antimuonium conversion and $\tau \to \mu e e$ rule out any observable effect for the present experiments due to $\mu^+ \to e^+ \bar\nu_e \nu_\ell$ for $\ell=e,\mu,\tau$, respectively. Applying similar arguments to flavor-changing semi-leptonic reactions we exclude the possibility that the "oscillation signals" observed at LSND are due to flavor-changing interactions that conserve total lepton number.Comment: 21 pages, 6 figures, Latex; minor correction

Matter effects and CP violating neutrino oscillations with non-decoupling heavy neutrinos

The evolution equation for active and sterile neutrinos propagating in general anisotropic or polarized background environment is found and solved for a special case when heavy neutrinos do not decouple, resulting in non-unitary mixing among light neutrino states. Then new CP violating neutrino oscillation effects appear. In contrast to the standard unitary neutrino oscillations these effects can be visible even for two flavour neutrino transitions and even if one of the elements of the neutrino mixing matrix is equal to zero. They do not necessarily vanish with $\delta m^{2} \to 0$ and they are different for various pairs of flavour neutrino transitions ($\nu_e \to \nu_\mu$), ($\nu_\mu \to \nu_\tau$), ($\nu_\tau \to \nu_e$). Neutrino oscillations in vacuum and Earth's matter are calculated for some fixed baseline experiments and a comparison between unitary and non-unitary oscillations are presented. It is shown, taking into account the present experimental constraints, that heavy neutrino states can affect CP and T asymmetries. This is especially true in the case of $\nu_\mu \to \nu_\tau$ oscillations.Comment: 18 pages, 6 fig

Can lepton flavor violating interactions explain the atmospheric neutrino problem?

We investigate whether flavor changing neutrino interactions (FCNIs) can be sufficiently large to provide a viable solution to the atmospheric neutrino problem. Effective operators induced by heavy boson exchange that allow for flavor changing neutrino scattering off quarks or electrons are related by an $SU(2)_L$ rotation to operators that induce anomalous tau decays. Since $SU(2)_L$ violation is small for New Physics at or above the weak scale, one can use the upper bounds on lepton flavor violating tau decays or on lepton universality violation to put severe, model-independent bounds on the relevant non-standard neutrino interactions. Also $Z$-induced flavor changing neutral currents, due to heavy singlet neutrinos, are too small to be relevant for the atmospheric neutrino anomaly. We conclude that the FCNI solution to the atmospheric neutrino problem is ruled out.Comment: 16 pages, no figures, Late

Diffusive spin transport

Information to be stored and transported requires physical carriers. The quantum bit of information (qubit) can for instance be realised as the spin 1/2 degree of freedom of a massive particle like an electron or as the spin 1 polarisation of a massless photon. In this lecture, I first use irreducible representations of the rotation group to characterise the spin dynamics in a least redundant manner. Specifically, I describe the decoherence dynamics of an arbitrary spin S coupled to a randomly fluctuating magnetic field in the Liouville space formalism. Secondly, I discuss the diffusive dynamics of the particle's position in space due to the presence of randomly placed impurities. Combining these two dynamics yields a coherent, unified picture of diffusive spin transport, as applicable to mesoscopic electronic devices or photons propagating in cold atomic clouds.Comment: Lecture notes, published in A. Buchleitner, C. Viviescas, and M. Tiersch (Eds.), "Entanglement and Decoherence. Foundations and Modern Trends", Lecture Notes in Physics 768, Springer, Berlin (2009

Cavity QED and quantum information processing with "hot" trapped atoms

We propose a method to implement cavity QED and quantum information processing in high-Q cavities with a single trapped but non-localized atom. The system is beyond the Lamb-Dick limit due to the atomic thermal motion. Our method is based on adiabatic passages, which make the relevant dynamics insensitive to the randomness of the atom position with an appropriate interaction configuration. The validity of this method is demonstrated from both approximate analytical calculations and exact numerical simulations. We also discuss various applications of this method based on the current experimental technology.Comment: 14 pages, 8 figures, Revte

The Dark Side of a Patchwork Universe

While observational cosmology has recently progressed fast, it revealed a serious dilemma called dark energy: an unknown source of exotic energy with negative pressure driving a current accelerating phase of the universe. All attempts so far to find a convincing theoretical explanation have failed, so that one of the last hopes is the yet to be developed quantum theory of gravity. In this article, loop quantum gravity is considered as a candidate, with an emphasis on properties which might play a role for the dark energy problem. Its basic feature is the discrete structure of space, often associated with quantum theories of gravity on general grounds. This gives rise to well-defined matter Hamiltonian operators and thus sheds light on conceptual questions related to the cosmological constant problem. It also implies typical quantum geometry effects which, from a more phenomenological point of view, may result in dark energy. In particular the latter scenario allows several non-trivial tests which can be made more precise by detailed observations in combination with a quantitative study of numerical quantum gravity. If the speculative possibility of a loop quantum gravitational origin of dark energy turns out to be realized, a program as outlined here will help to hammer out our ideas for a quantum theory of gravity, and at the same time allow predictions for the distant future of our universe.Comment: 24 pages, 2 figures, Contribution to the special issue on Dark Energy by Gen. Rel. Gra

On Neutrino Masses and a Low Breaking Scale of Left-Right Symmetry

In left-right symmetric models (LRSM) the light neutrino masses arise from two sources: the seesaw mechanism and a VEV of an SU(2)$_L$ triplet. If the left-right symmetry breaking, $v_R$, is low, v_R\lsim15\TeV, the contributions to the light neutrino masses from both the seesaw mechanism and the triplet Yukawa couplings are expected to be well above the experimental bounds. We present a minimal LRSM with an additional U(1) symmetry in which the masses induced by the two sources are below the eV scale and the two-fold problem is solved. We further show that, if the U(1) symmetry is also responsible for the lepton flavor structure, the model yields a small mixing angle within the first two lepton generations.Comment: 18 pages references added published versio

Energy Contents of Some Well-Known Solutions in Teleparallel Gravity

In the context of teleparallel equivalent to General Relativity, we study energy and its relevant quantities for some well-known black hole solutions. For this purpose, we use the Hamiltonian approach which gives reasonable and interesting results. We find that our results of energy exactly coincide with several prescriptions in General Relativity. This supports the claim that different energy-momentum prescriptions can give identical results for a given spacetime. We also evaluate energy-momentum flux of these solutions.Comment: 16 pages, accepted for publication in Astrophys. Space Sc