Stochastic Reaction-diffusion Equations Driven by Jump Processes

We establish the existence of weak martingale solutions to a class of second order parabolic stochastic partial differential equations. The equations are driven by multiplicative jump type noise, with a non-Lipschitz multiplicative functional. The drift in the equations contains a dissipative nonlinearity of polynomial growth.Comment: See journal reference for teh final published versio

Strategies discussed at the XIIth international conference on Kangaroo mother care for implementation on a countrywide scale.

AIM: Building strategies for the country-level dissemination of Kangaroo mother care (KMC) to reduce the mortality rate in preterm and low birth weight babies and improve quality of life. KMC is an evidence-based healthcare method for these infants. However, KMC implementation at the global level remains low. METHODS: The international network in Kangaroo mother brought 172 KMC professionals from 33 countries together for a 2-day workshop held in conjunction with the XIIth International KMC Conference in Bogota, Colombia, in November 2018. Participants worked in clusters to formulate strategies for country-level dissemination and scale-up according to seven pre-established objectives. RESULTS: The minimum set of indicators for KMC scale-up proposed by the internationally diverse groups is presented. The strategies for KMC integration and implementation at the country level, as well as the approaches for convincing healthcare providers of the safety of KMC transportation, are also described. Finally, the main aspects concerning KMC follow-up and KMC for term infants are presented. CONCLUSION: In this collaborative meeting, participants from low-, middle- and high-income countries combined their knowledge and experience to identify the best strategies to implement KMC at a countrywide scale

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

The influence of academic self–confidence on mathematics achievement

MEd (Learner Support), North-West University, Vaal Triangle Campus, 2013It seems as if there is a continued problem with mathematical performances nationally. The rate, at which FET (Further Education and Training) phase learner s discontinue Mathematics as a result of poor mathematical performances, is of great concern. This research study determined how academic self-confidence could have an influence on learners’ abilities to perform in Mathematics. The literature review confirmed that there could be a link between academic self-confidence and mathematical performance. Consequently, the researcher wanted to establish if the same could be found at a school where the emphasis is very much on mathematical achievement. The school is based in Northern Johannesburg (D10) in Gauteng, South Africa. By applying an explanatory mixed method approach (quantitative, followed by qualitative methods), the researcher identified a clear link between this school’s learners’ abilities to perform in Mathematics and their academic self-confidence. Amongst others, positive links were also identified between the learner s’ comprehension of Mathematics, their problem- solving skills as well as educator assistance, which in turn influence their academic self - confidence and consequently al so their performance s. A cycle of mathematical influences was identified that demonstrated that the influence i s not only working one way, but that a cycle forms; academic self-confidence influences the learner’s ability to perform in mathematics and mathematical performance s al so influence academic self - confidence, causing a continuous cycle of influence.Master

Alnus shrub expansion increases evapotranspiration in the Swiss Alps

Shrub encroachment is one of the main consequences of abandonment of montane grassland. Higher surface roughness of shrubs leads to stronger aerodynamic coupling. This should increase evapotranspiration (ET), but lower surface temperatures (due to higher ET and reduced aerodynamic resistance) could counter this effect. We explored this question by employing weighable lysimeters in adjacent grass- and shrubland understorey, and by measuring canopy transpiration in Alnus with sap flow sensors at 1675 m a.s.l. in the Swiss central Alps. For 11 bright days, ET rates of Alnus clearly exceeded those from grassland by on average 31 ± 14% or 1.2 ± 0.6 mm d−1 (mean ± sd). During days with a high vapour pressure deficit (VPD), differences in ET were largest, indicating that enhanced aerodynamic coupling had a greater influence than evaporative cooling. Cooler Alnus than grassland canopies were confirmed by infrared thermography. For the growing season (mid May to end of September), we estimate that this increase in ET results in a reduction in runoff by 78 to 81 mm (2010, 2011). Accounting for the falling height of water, this lower runoff reduces the hydro-electric potential of the upper Reuss catchment (227 km2) by 0.47Mio Swiss Franc (CHF) per growing season (same amount in US Dollar (USD); Alnus cover analysed for the year 2004/05) and by 1.8 Mio CHF for a scenario where all grasslands below the natural treeline would be converted into shrubland. So, shrub encroachment clearly exerts hydrological drawbacks

A technical guide to develop a statistically valid fish-based index in compliance with the water framework directive: an evaluation for Turkish freshwaters

Abstract Fish are considered as reliable indicators of environmental quality and during the last decades several fish-based indices have been developed to assess the ecological status of water bodies in compliance with the water framework directive. The high number of fish species with a high degree of endemism, lack of knowledge on ecological requirements of certain fish species, absence of a complete dataset for reference conditions, and great variation among freshwater types complicate the development of fish-based indices for Turkish freshwaters. However, this is still possible using statistical approaches. This paper presents a practical guide which is mainly based on the recent approaches that have frequently been used in other countries worldwide. Data collection, metric selection and scoring, ecological quality ratio (EQR) calculation and validation steps are described and discussed with respect to the limitations and available data for Turkish freshwaters. The guide documented here, with minor adjustments, has a potential to be adopted as a fish-based assessment approach for the ecological status in freshwaters in Turkey and adjacent countries