Screen-detected colorectal cancers are associated with an improved outcome compared with stage-matched interval cancers

Background: Colorectal cancers (CRCs) detected through the NHS Bowel Cancer Screening Programme (BCSP) have been shown to have a more favourable outcome compared to non-screen-detected cancers. The aim was to identify whether this was solely due to the earlier stage shift of these cancers, or whether other factors were involved. Methods: A combination of a regional CRC registry (Northern Colorectal Cancer Audit Group) and the BCSP database were used to identify screen-detected and interval cancers (diagnosed after a negative faecal occult blood test, before the next screening round), diagnosed between April 2007 and March 2010, within the North East of England. For each Dukes' stage, patient demographics, tumour characteristics, and survival rates were compared between these two groups. Results: Overall, 322 screen-detected cancers were compared against 192 interval cancers. Screen-detected Dukes' C and D CRCs had a superior survival rate compared with interval cancers (P=0.014 and P=0.04, respectively). Cox proportional hazards regression showed that Dukes' stage, tumour location, and diagnostic group (HR 0.45, 95% CI 0.29-0.69, P<0.001 for screen-detected CRCs) were all found to have a significant impact on the survival of patients. Conclusions: The improved survival of screen-detected over interval cancers for stages C and D suggest that there may be a biological difference in the cancers in each group. Although lead-time bias may have a role, this may be related to a tumour's propensity to bleed and therefore may reflect detection through current screening tests

Mechanics of the exceptional anuran ear

The anuran ear is frequently used for studying fundamental properties of vertebrate auditory systems. This is due to its unique anatomical features, most prominently the lack of a basilar membrane and the presence of two dedicated acoustic end organs, the basilar papilla and the amphibian papilla. Our current anatomical and functional knowledge implies that three distinct regions can be identified within these two organs. The basilar papilla functions as a single auditory filter. The low-frequency portion of the amphibian papilla is an electrically tuned, tonotopically organized auditory end organ. The high-frequency portion of the amphibian papilla is mechanically tuned and tonotopically organized, and it emits spontaneous otoacoustic emissions. This high-frequency portion of the amphibian papilla shows a remarkable, functional resemblance to the mammalian cochlea

Analysis of Fully Polarimetric Laboratory Measurements Performed with the WISDOM Radar

The Ground Penetrating Radar WISDOM (Water Ice Subsurface Deposit Observation on Mars) is one of the instruments selected to be part of the Pasteur payload of ESA's ExoMars Rover mission. The main scientific objectives of the Pasteur payload are to search for evidence of past and present life on Mars and to characterize the nature of the shallow subsurface. WISDOM is capable to obtain subsurface information along the rover path and to explore the first 3 meters of the soil with a vertical resolution of a few centimeters. WISDOM will help identify the location of sedimentary layers, where organic molecules are most likely to be found. By investigating geometry, location and properties of buried reflectors, WISDOM will contribute to the understanding of the 3D geological structure, electromagnetic nature, and, possibly, the state of water and ice in the shallow subsurface. WISDOM measurements will be performed 1) by conducting periodic soundings along the Rover traverse, which will provide a coarse, non-uniform, but positionally well-determined investigation of the landing site and 2) by selected high-resolution surveys of areas of strong scientific interest, which are identified for potential investigation and sampling by the Rover's drill. Such surveys will generally be conducted by acquiring a number of closely spaced parallel profiles. Supported by specific hardware features, like the arrangement of the fully polarimetric antenna system, an interpolated 3-D subsurface map of the local stratigraphy can be constructed from these radar measurements. Laboratory measurements are performed on a planar scanner in the anechoic chamber to simulate the closely spaced parallel profiles of selected high-resolution surveys. To characterize the performance of the radar and to be able to analyze the influence of radiation coupling effects between the rover and the antennas, the fully polarimetric WISDOM antenna system was mounted on a simple rover-like mockup. Calibration algorithms were applied to reduce the interference from radiation coupling and cross-talk between transmitting and receiving antenna. The analysis of the laboratory measurement will show features of the fully polarimetric radar system and quantify most of the important performance parameters. Synthetic aperture processing is implemented to increase the azimuth resolution of radar. The three dimensional reconstruction of the positioning of an arrangement of discrete objects will be shown

What Can Crystallographic Orientation Tell Us About Nakhlite Formation?

No abstract available

WISDOM GPR investigations in a Mars-analog environment during the SAFER rover operation simulation

International audienceThe WISDOM (Water Ice Subsurface Deposits Observations on Mars) Ground Penetrating Radar has been selected to be onboard the ExoMars 2018 rover mission [1]. This instrument will investigate the Martian shallow subsurface and provide the geological context of the mission, by characterizing the subsurface in terms of structure, stratigraphy and potential buried objects. It will also quantify the geoelectrical properties of the medium, which are directly related to its nature, its water or salts content and its hardness [2]. WISDOM data will provide important clues to guide the drilling operations to location of potential exobiological interest. A prototype available in LATMOS, France, is currently tested in a wide range of natural environments. In this context, the WISDOM team participated in the SAFER (Sample Acquisition Field Experiment with a Rover) field trial that occurred from 7th to 13th October 2013 in the Atacama Desert, Chile. Designed to gather together scientists and engineers in a context of a real Martian mission with a rover, the SAFER trial was the opportunity to use three on-board ExoMars instruments, namely CLUPI (Close-UP Imager), PANCAM (Panoramic Camera) and WISDOM, to investigate the chosen area. We present the results derived from WISDOM data acquired over the SAFER trial site to characterize the shallow subsurface of the area

Nakhlite Emplacement Mechanisms from Electron Backscatter Diffraction

No abstract available