ECH and ECCD modelling studies for DTT

In this work the Electron Cyclotron (EC) physics performances of the EC system foreseen for the new Divertor Tokamak Test facility (DTT) are investigated using the beam tracing code GRAY on the flat top phase of the most recent DTT full power scenario. The whole core plasma region can be reached by EC beams with complete absorption, assuring bulk heating and core current drive (CD) for profile tailoring, and NTM mitigation in correspondence of the rational surfaces. A detailed analysis regarding modifications of the EC propagation, absorption and CD location due to density fluctuations caused by pellet injection is performed. The compatibility between the EC system and the pellet injection system is verified: the density variations due to pellet injection are foreseen to negligibly influence the EC performances, allowing the EC beams to reach the plasma central region for bulk heating and to drive current on the rational surfaces for NTM mitigation. Finally, the polarization variations originated by the angle steering foreseen for the operational and physics tasks accomplishment during the flat top phase of the discharge are assessed. Negligible power losses have been found keeping fixed polarization during the needed steering

EU DEMO EC equatorial launcher pre-conceptual performance studies

The preliminary conceptual design for the Electron Cyclotron (EC) system of the future European DEMOnstration fusion power plant is ongoing in the EUROfusion Consortium. This represents one of the key aspects in order to assess the performances and the integration capabilities of such a system in EU DEMO as well as in the alternative reactor configuration Flexi-DEMO. Different options for the antenna, namely remote steering antenna (RSA), open ended waveguides (OEWG) and the front steering antenna (FSA) later on renamed in mid steering antenna (MSA) to notify that the MSA is protected behind the breeding blanket (BB) in DEMO, are investigated, analyzing their performance for several injection angles and launch points. This activity considers the constraints given by physics and engineering requirements, as for example the maximum power per port and the necessary local current drive to stabilize neo-classical tearing modes (NTMs) with a proper deposition width. The beam tracing calculations have been performed on different scenarios, providing information on plasma accessibility and deposited power. The microwave design and initial ideas about the ex-vessel EC transmission lines routing will be shown

Side emissions during EC injection for PDI studies in FTU tokamak

The evidence of Parametric Decay Instabilities (PDI) excited by the ECH power injected in O-Mode has been explored in FTU Tokamak, using the Collective Thomson Scattering (CTS) diagnostic. The experiments show evidences to support the hypothesis of low-threshold excitation of waves generated by PDI mechanisms, formerly proposed in the case of 2nd harmonic X-mode injection in TEXTOR and ASDEX-U. Theoretical analysis predicts low-threshold parametric decay also for O-mode pump-wave injection, which can be injected in FTU at frequencies close to the first Harmonic EC resonance. Experiments were made at different magnetic fields, injecting the 140 GHz probe and observing the emission from the second antenna of the EC launcher in poloidally symmetric and asymmetric configurations, in presence of MHD islands. The signal is detected by the CTS radiometers, with a fast digitizer allowing the spectral reconstruction at very fine time and frequency scales. Different types of emissions are studied in detail, comparing them with the magnetic island rotation frequency in different plasma conditions. In order to locate the plasma volume originating the emissions, a new antenna and receiving line has been installed

Side emissions during EC injection for PDI studies in FTU tokamak

The evidence of Parametric Decay Instabilities (PDI) excited by the ECH power injected in O-Mode has been explored in FTU Tokamak, using the Collective Thomson Scattering (CTS) diagnostic. The experiments show evidences to support the hypothesis of low-threshold excitation of waves generated by PDI mechanisms, formerly proposed in the case of 2nd harmonic X-mode injection in TEXTOR and ASDEX-U. Theoretical analysis predicts low-threshold parametric decay also for O-mode pump-wave injection, which can be injected in FTU at frequencies close to the first Harmonic EC resonance. Experiments were made at different magnetic fields, injecting the 140 GHz probe and observing the emission from the second antenna of the EC launcher in poloidally symmetric and asymmetric configurations, in presence of MHD islands. The signal is detected by the CTS radiometers, with a fast digitizer allowing the spectral reconstruction at very fine time and frequency scales. Different types of emissions are studied in detail, comparing them with the magnetic island rotation frequency in different plasma conditions. In order to locate the plasma volume originating the emissions, a new antenna and receiving line has been installed

BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors

Despite negative results of clinical trials conducted on the overall population of patients with gastric cancer, PARP inhibitor (PARPi) therapeutic strategy still might represent a window of opportunity for a subpopulation of patients with gastric cancer. An estimated 7% to 12% of gastric cancers exhibit a mutational signature associated with homologous recombination (HR) failure, suggesting that these patients could potentially benefit from PARPis. To analyze respon-siveness of gastric cancer to PARPi, we exploited a gastroesophageal adenocarcinoma (GEA) platform of patient-derived xenografts (PDX) and PDX-derived primary cells and selected 10 PDXs with loss-of-function mutations in HR pathway genes. Cell viability assays and preclinical trials showed that olaparib treatment was effective in PDXs harboring BRCA2 germline mutations and somat-ic inactivation of the second allele. Olaparib responsive tumors were sensitive to oxaliplatin as well. Evaluation of HR deficiency (HRD) and mutational signatures efficiently stratified responder and nonresponder PDXs. A retrospective analysis on 57 patients with GEA showed that BRCA2 inactivating variants were associated with longer progression-free survival upon platinum-based regi-mens. Five of 7 patients with BRCA2 germline mutations carried the p.K3326* variant, classified as "benign." However, familial history of cancer, the absence of RAD51 foci in tumor cells, and a high HRD score suggest a deleterious effect of this mutation in gastric cancer. In conclusion, PARPis could represent an effective therapeutic option for BRCA2-mutated and/or high HRD score patients with GEA, including patients with familial intestinal gastric cancer

International Variations in Surgical Morbidity and Mortality Post Gynaecological Oncology Surgery: A Global Gynaecological Oncology Surgical Outcomes Collaborative Led Study (GO SOAR1)

Simple Summary Little is known about factors contributing to early post-operative morbidity and mortality in low and middle income countries with a paucity of data limiting global efforts to improve gynaecological cancer care. In this multicentre, international prospective cohort study of women undergoing gynaecological oncology surgery, we show that low and middle versus high income countries were associated with similar post-operative major morbidity. Capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention.Abstract Gynaecological malignancies affect women in low and middle income countries (LMICs) at disproportionately higher rates compared with high income countries (HICs) with little known about variations in access, quality, and outcomes in global cancer care. Our study aims to evaluate international variation in post-operative morbidity and mortality following gynaecological oncology surgery between HIC and LMIC settings. Study design consisted of a multicentre, international prospective cohort study of women undergoing surgery for gynaecological malignancies (NCT04579861). Multilevel logistic regression determined relationships within three-level nested-models of patients within hospitals/countries. We enrolled 1820 patients from 73 hospitals in 27 countries. Minor morbidity (Clavien-Dindo I-II) was 26.5% (178/672) and 26.5% (267/1009), whilst major morbidity (Clavien-Dindo III-V) was 8.2% (55/672) and 7% (71/1009) for LMICs/HICs, respectively. Higher minor morbidity was associated with pre-operative mechanical bowel preparation (OR = 1.474, 95%CI = 1.054-2.061, p = 0.023), longer surgeries (OR = 1.253, 95%CI = 1.066-1.472, p = 0.006), greater blood loss (OR = 1.274, 95%CI = 1.081-1.502, p = 0.004). Higher major morbidity was associated with longer surgeries (OR = 1.37, 95%CI = 1.128-1.664, p = 0.002), greater blood loss (OR = 1.398, 95%CI = 1.175-1.664, p <= 0.001), and seniority of lead surgeon, with junior surgeons three times more likely to have a major complication (OR = 2.982, 95%CI = 1.509-5.894, p = 0.002). Of all surgeries, 50% versus 25% were performed by junior surgeons in LMICs/HICs, respectively. We conclude that LMICs and HICs were associated with similar post-operative major morbidity. Capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention