Role of radiologic imaging in genetic and acquired neuromuscular disorders

Great technologic and clinical progress have been made in the last two decades in identifying genetic defects of several neuromuscular diseases, as Spinal Muscular Atrophy, genetic muscular dystrophies and other genetic myopathies. The diagnosis is usually challenging, due to great variability in genetic abnormalities and clinical phenotypes and the poor specificity of complementary analyses, i.e., serum creatine kinase (CK) and electrophysiology. Muscle biopsy represents the gold standard for the diagnosis of genetic neuromuscular diseases, but clinical imaging of muscle tissue is an important diagnostic tool to identify and quantifyies muscle damage. Radiologic imaging is, indeed, increasingly used as a diagnostic tool to describe patterns and the extent of muscle involvement, thanks to modern techniques that enable to definethe definition of degrees of muscle atrophy and changes in connective tissue. They usually grade the severity of the disease process with greater accuracy than clinical scores. Clinical imaging is more than complementary to perform muscle biopsy, especially as ultrasound scans are often mandatory to identify the muscle to be biopsied. We will here detail and provideWe will herein provide detailed examples of the radiologic methods that can be used in genetic and acquired neuromuscular disorders, stressing pros and cons

Underwater photogrammetry and 3D reconstruction of marble cargos shipwreck

Nowadays archaeological and architectural surveys are based on the acquisition and processing of point clouds, allowing a high metric precision, essential prerequisite for a good documentation. Digital image processing and laser scanner have changed the archaeological survey campaign, from manual and direct survey to a digital one and, actually, multi-image photogrammetry is a good solution for the underwater archaeology. This technical documentation cannot operate alone, but it has to be supported by a topographical survey to georeference all the finds in the same reference system. In the last years the Ca' Foscari and IUAV University of Venice are conducting a research on integrated survey techniques to support underwater metric documentation. The paper will explain all the phases regarding the survey's design, images acquisition, topographic measure and the data processing of two Roman shipwrecks in south Sicily. The cargos of the shipwrecks are composed by huge marble blocks, but they are different for morphological characteristic of the sites, for the depth and for their distribution on the seabed. Photogrammetrical and topographical surveys were organized in two distinct methods, especially for the second one, due to the depth that have allowed an experimentation of GPS RTK's measurements on one shipwreck. Moreover, this kind of three-dimensional documentation is useful for educational and dissemination aspect, for the ease of understanding by wide public

DIGITAL SURVEY TECHNIQUES FOR THE DOCUMENTATION OF WOODEN SHIPWRECKS

Nowadays, researchers widely employ the acquisition of point clouds as one of the principal type of documentation for cultural heritage. In this paper, different digital survey techniques are employed to document a wooden ancient shipwreck, a particular and difficult kind of archaeological finding due to its material characteristics. The instability of wood and the high costs of restoration do not always offer the opportunity of recovering and showing the hull to researchers and public and three-dimensional surveys are fundamental to document the original conditions of the wood. The precarious conditions of this material in contact with air could modify the structure and the size of the boat, requiring a fast and accurate recording technique. The collaboration between Ca' Foscari University and the Laboratory of Photogrammetry of Iuav University of Venice has given the possibility to demonstrate the utility of these technology. We have surveyed a sewn boat of Roman age through multi-image photogrammetry and laser scanner. Point clouds were compared and a residual analysis was done, to verify the characteristics and the opportunity of the two techniques, both of them have allowed obtaining a very precise documentation from a metrical point of view

Photogrammetry in maritime and underwater archaeology: two marble wrecks from Sicily

Underwater survey, compared to land archaeology, needs some specific techniques, because the application of some active 3D sensor, such as laser scanner, is obviously impossible. The necessity to produce three-dimensional survey, offering the same accuracy of classical terrestrial laserscanning or photogrammetric methods, combined with the request of low costs and rapid solutions, led the researchers to test and apply oftentimes image-based techniques.In the last two years the Ca' Foscari University and University IUAV of Venice are conducting a research on the application of integrated techniques to support underwater metric documentation, comparing them to the manual traditional one. The gained experience (and confirmed by other recently published papers) shows that the actual multi-image digital photogrammetry is a good solution for the underwater archaeology. This approach is useful both from a metric and from a recording point of view, because it achieves high quality results, such as accurate 3D models or 2D representations, offering a complete documentation of underwater sites.But photogrammetry has to be supported by a topographical survey (to acquire ground control points - GCP) to georeference all the finds in the same reference system. This paper presents the integrated survey of two roman shipwrecks, approaching differently in the GCP's acquisition just for the different morphological characteristic of the sites. The wrecks' cargos are huge marble blocks, presenting differences in quantities, layout and depths. Those characteristics determine the choice of the topographic survey.The results of the survey are two 3D polygonal textured models of the sites, which can be easily used for different analyses and reconstructive hypothesis, opening new possibilities of documentation with both specialists and the wider public. Furthermore, 3D models are the geometric base for 2D orthophoto and cross section extraction. The paper will illustrate all the phases regarding the survey's design, acquisition and realization and the data processing to obtain 2D and 3D final representation

The Mercurio gunflints: a techno-typological and cultural assessment

The discovery of the wreck of the brig Mercurio, which sank in 1812 in the waters of the north Adriatic, is of major significance for the study of Italic Kingdom vessels from the Napoleonic era. The underwater excavations carried out in 2004-11 led to the recovery of many small finds, among which are several gunflints of different size and shape. The Mercurio gunflints were produced mainly from blades using a technique in use in Britain and France, but also in the workshops of the Lessini Hills around Ceredo (Verona province, northern Italy). We suggest that the flint employed for their manufacture probably came from Monte Baldo, in the Trentino, or perhaps from the River Tagliamento, in Friuli. We can exclude the possibility that the specimens recovered from the shipwreck were made from French flint because of the typically north Italian manufacturing technique and the character of the grey Treveti-derived flint. Given the complexity of the period during which the Grado (or Pirano) battle took place, the study of even such small items can contribute to a better interpretation of the dramatic events that characterised the beginning of the nineteenth century in that part of the Mediterranean