431 research outputs found

    Cytokine Regulation of Teleost Inflammatory Responses

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    Magnetism in La2O3(Fe1-xMnx)2Se2 tuned by Fe/Mn ratio

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    We report the evolution of structural and magnetic properties in La2O3(Fe1-xMnx)2Se2. Heat capacity and bulk magnetization indicate an increased ferromagnetic component of the long-range magnetic order and possible increased degree of frustration. Atomic disorder on Fe(Mn) sites suppresses the temperature of the long-range order whereas intermediate alloys show a rich magnetic phase diagram.Comment: 7 pages, 7 figure

    Teleost contributions to the understanding of mycobacterial diseases

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    Few pathogens have shaped human medicine as the mycobacteria. From understanding biological phenomena driving disease spread, to mechanisms of host-pathogen interactions and antibiotic resistance, the Mycobacterium genus continues to challenge and offer insights into the basis of health and disease. Teleost fish models of mycobacterial infections have progressed significantly over the past three decades, now supplying a range of unique tools and new opportunities to define the strategies employed by these Gram-positive bacteria to overcome host defenses, as well as those host antimicrobial pathways that can be used to limit its growth and spread. Herein, we take a comparative perspective and provide an update on the contributions of teleost models to our understanding of mycobacterial diseases

    Enhancing photocatalytic properties of rutile TiO2 by codoping with N and metals e Ab initio study

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    Substitutional N to O and M to Ti (M = Pt, V, Sb) codoped rutile TiO2 was investigated using density functional theory (DFT) based calculations with both standard and hybrid exchange-correlation functionals. The band gaps calculated using generalized gradient approximation (GGA) exhibited narrowing compared to the pure rutile TiO2 in all the investigated cases. In contrast, the results obtained with hybrid exchange-correlation functional showed that there was no band gap narrowing, but doping induced localized states within the band gap just above the valence band, as well as below the conduction band for Pt doped TiO2. The presence of broad intermediate states (IS) in the band gap could enhance visible light absorption through a two step optical transition from the valence to the conduction band via the IS and at the same time lower recombination of the photogenerated charges

    muCool: A novel low-energy muon beam for future precision experiments

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    Experiments with muons (μ+\mu^{+}) and muonium atoms (μ+e\mu^{+}e^{-}) offer several promising possibilities for testing fundamental symmetries. Examples of such experiments include search for muon electric dipole moment, measurement of muon g2g-2 and experiments with muonium from laser spectroscopy to gravity experiments. These experiments require high quality muon beams with small transverse size and high intensity at low energy. At the Paul Scherrer Institute, Switzerland, we are developing a novel device that reduces the phase space of a standard μ+\mu^{+} beam by a factor of 101010^{10} with 10310^{-3} efficiency. The phase space compression is achieved by stopping a standard μ+\mu^{+} beam in a cryogenic helium gas. The stopped μ+\mu^{+} are manipulated into a small spot with complex electric and magnetic fields in combination with gas density gradients. From here, the muons are extracted into the vacuum and into a field-free region. Various aspects of this compression scheme have been demonstrated. In this article the current status will be reported.Comment: 8 pages, 5 figures, TCP 2018 conference proceeding

    Impacts of Low Temperature on the Teleost Immune System

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    As poikilothermic vertebrates, fish can experience changes in water temperature, and hence body temperature, as a result of seasonal changes, migration, or efflux of large quantities of effluent into a body of water. Temperature shifts outside of the optimal temperature range for an individual fish species can have negative impacts on the physiology of the animal, including the immune system. As a result, acute or chronic exposure to suboptimal temperatures can impair an organisms’ ability to defend against pathogens and thus compromise the overall health of the animal. This review focuses on the advances made towards understanding the impacts of suboptimal temperature on the soluble and cellular mediators of the innate and adaptive immune systems of fishes. Although cold stress can result in varying effects in different fish species, acute and chronic suboptimal temperature exposure generally yield suppressive effects, particularly on adaptive immunity. Knowledge of the effects of environmental temperature on fish species is critical for both the optimal management of wild species and the best management practices for aquaculture species.Natural Sciences and Engineering Research Council of Canada Discovery Grant (NSERC DG) to Barbara A. KatzenbackCanada Research Council Research Chair and NSERC DG to Brian DixonGraduate Teaching Assistantship from the Department of Biology at University of Waterloo to Quinn H. Abra

    First principles calculations of tetragonal FeX X S, Se, Te Magnetism, hyperfine interaction, and bonding

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    Magnetic ground states, local crystallographic environment of Fe, and hyperfine interaction parameters in tetragonal FeX X S, Se, Te are investigated by means of density functional theory DFT calculations using augmented plane waves plus local orbitals APW lo method. We use several different mag netic configurations to evaluate the magnetic and electronic properties of this system, as well as the hyperfine interaction parameters at Fe lattice site. The results obtained for the ground state collinear anti ferromagnetic arrangement relatively well reproduce the quadruple splitting and isomer shifts from the available Mössbauer measurements. The Bader s atoms in molecule charge density analysis indicates bonding of closed shell type and a sizable charge transfer from Fe to X . The system properties are sensitive to the structural optimization of the position of the chalcogen atom with respect to the iron plan
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