Two new quassinoids from Simaba multiflora fruits

Deux nouveaux quassinoïdes ont été isolés des fruits de #Simaba multiflora$ récoltés en Guyane Française : la 13, 18-dehydro- 6 alpha-senecioyloxy-chaparinne et la 12-dehydro 6 alpha-senecioyloxy-chaparinne. L'élucidation de la structure de ce dernier quassinoïde, actif sur la leucémie murine P388, faut appel aux techniques de la RMN bidimensionnelle, 2D delta delta, dite de corrélation hétéro-nucléaire. (Résumé d'auteur

Magnetic resonance imaging of Klebsiella pneumoniae-induced pneumonia in mice

In vivo imaging of small animals is a rapidly developing field. However, the potential of global imaging of infectious processes in animal models remains poorly explored. We used magnetic resonance imaging (MRI) to follow the development and regression of inflammatory lesions caused by infection by Klebsiella pneumoniae in mouse lungs. A virulent strain caused an intense inflammation within 2 days in the whole lungs, while an avirulent strain did not show significant changes. Mice infected with the virulent strain and subsequently treated with antibiotics presented a severe inflammation localized mainly in the left lung that disappeared after a week. The lesions observed by MRI correlated with the damage seen by histological analysis and a 3D representation of the tissue allowed better visualization of the development and healing of inflammatory lesions. MRI thus represents a powerful technique to study in vivo the interactions between a pathogen and its host in real time

Utilisation de la RMN a haut champ pour l'elucidation des phenomenes biologiques. Applications aux domaines medical et du medicament

SIGLECNRS AR 12822 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Both functional LTβ receptor and TNF receptor 2 are required for the development of experimental cerebral malaria

10.1371/journal.pone.0002608PLoS ONE37e260