1,038 research outputs found
Characterization of a nonlinear sound absorber at low frequencies and high sound levels
International audienceTo characterize nonlinear acoustic loads identification techniques have been developed. A specific setup of impedance tube named “Short Kundt’s Tube” (SKT) was built to reach high sound levels at low frequencies. Two approaches, developed in the frequency domain,are discussed: a linearization method giving access to the acoustic impedance and a nonlinear model which is able to characterize energy transfer to higher harmonics. Both are excitation level dependent
The principal at risk: Stress and organizing mindfulness in the school context
Background: In recent years the role of school principals is becoming increasingly complex and responsible. Methods: This study was voluntarily attended by 419 Italian school principals who were administered the Psychological Stress Measurement (MSP), Mindfulness Organizing Scale (MOS), Polychronic-Monochronic Tendency Scale (PMTS), and the Scale of Emotions at Work (SEW). Results: The study has produced a path analysis model in which the relationships between the main predictors of principals’ work discomfort were explained. The effect of depressive anxiety on perceived discomfort (ß = 0.517) found a protective mediator in the mindfulness component that recognizes the sharing as a fundamental operational tool (ß = −0.206), while an increasing sense of effort and confusion could significantly amplify the experience of psychological discomfort associated with the exercise of school leadership (ß = 0.254). Conclusions: The model developed in this study suggests that focusing on organizing mindfulness can be a valuable guideline for interventions
Comparaison de techniques d'absorptions vibro-acoustiques
National audienceThis study presents the design of a test-rig built to caracterize a vibro-acoustical absorber. This experimental system is based on the properties of a short Kundt tube allowing low frequencies studies (below the first natural frequency of the tube). A precise measure method (surdetermined two-microphones method) is proposed in order to obtain the desired acoustical parameters of the absorber. Finally, we propose an energy balance of the obtanied frequency response (excitation frequency and its harmonics).Cette étude propose la conception d'un banc d'essai servant à la caractérisation d'absorbeurs vibro-acoustiques. Ce banc est conç u sur la propriété d'un tube de Kundt court permettant le travail en basses fréquences (en-dessous de la première fréquence de résonance du tube). Une méthode de me-sure fine (méthode à deux microphones surdéterminée) est mise en place afin d'extraire les paramètres acoustiques souhaités de l'absorbeur et in fine proposer un bilan énergétique résultant et sa répartition spectrale (fréquence d'excitation et ses harmoniques)
Birth control knowledge among freshmen of four Italian universities
Since sexual health education (SHE) is not mandatory in Italian schools, we conducted a survey on
freshmen of four Italian university campuses in 2012 to investigate the respective level of sexual
health knowledge (SHK) in relation to birth control, with the aim to inform public health policy
makers. A convenience strategy was employed to sample 4,552 freshmen registered with various
undergraduate courses at four Italian universities: Padua university (Veneto Region); university of
Milan (Lombardy Region); university of Bergamo (Lombardy Region); university of Palermo (Sicily
Region). We investigated the level of SHK on birth control using 6 proxy indicators: (1) the average
length of a woman\u2019s period [outcome with 3 levels: wrong (base) vs. acceptable vs. correct]; (2) the
most fertile interval within a woman\u2019s period (binary outcome: correct vs. wrong answer); (3) the event
between the end of a period and the beginning of the next cycle (binary outcome: correct vs. wrong
answer); (4) the average survival of spermatozoa in the womb (binary outcome: correct vs. wrong
answer); (5) the concept of contraception (binary outcome: correct vs. wrong answer); (6) the efcacy
of various contraceptives to prevent unintended pregnancies (linear score: 0\u201317). We ftted 6 separate
models of multiple regression: multinomial for outcome 1; logistic for outcomes 2, 3, 4, 6; linear for
outcome 6. Statistical estimates were adjusted for a number of socio-demographic factors. Results
were expressed as odds ratios (OR) for the 4 multiple logistic regression models, linear coefcients
(RC) for the linear regression model and relative risk ratio (RRR) for the multinomial logistic regression
model. The level of signifcance of each risk estimate was set at 0.05. The level of SHK of freshmen
sampled was rather low, as 60% interviewees did not know the average length of a woman\u2019s period,
the average survival of spermatozoa in the womb and the concept of contraception, whilst the most
fertile interval within a woman\u2019s period was known only to 55% of interviewees. The mean score of
SHK on the efcacy of various contraceptive methods was only 5 (scale 0\u201317). Some categories of
students were consistently and signifcantly less knowledgeable on birth control at multivariable
analysis: males; students from the university of Palermo; those with vocational secondary school
education and those not in a romantic relationship at the time the survey was conducted. The results
of this survey clearly call for the introduction of SHE programs in Italian schools, as already done
in several European countries. School SHE should start as early as possible, ideally even before
secondary school. SHE should be holistic and delivered with a multiple agency coordinated approach
involving the Ministry of Health, the Ministry of Education, University and Scientifc Research (MIUR),
families, schools, public health departments, primary health care providers, pharmacists, media,
other
A Simple Microwave Imaging System for Food Product Inspection through a Symmetry-Based Microwave Imaging Approach
In the food industry, there is a growing demand for cost-effective methods for the inline inspection of food items able to non-invasively detect small foreign bodies that may have contaminated the product during the production process. Microwave imaging may be a valid alternative to the existing technologies, thanks to its inherently low-cost and its capability of sensing low-density contaminants. In this paper, a simple microwave imaging system specifically designed to enable the inspection of a large variety of food products is presented. The system consists of two circularly loaded antipodal Vivaldi antennas with a very large operative band, from 1 to 15 GHz, thus allowing a suitable spatial resolution for different food products, from mostly fatty to high water-content foods. The antennas are arranged in such a way as to collect a signal that can be used to exploit a recently proposed real-time microwave imaging strategy, leveraging the inherent symmetries that usually characterize food items. The system is experimentally characterized, and the achieved results compare favorably with the design specifications and numerical simulations. Relying on these positive results, the first experimental proof of the effectiveness of the entire system is presented confirming its efficacy
A Survey on Knowledge, Prevention, and Occurrence of Sexually Transmitted Infections among Freshmen from Four Italian Universities
Background. The peak of sexually transmitted infections (STI) among adolescents/young adults suggests a low level of prevention. In order to assess whether the level of sexual health education (SHE), received by several channels, was effective at improving sexual behaviors, we conducted a survey among freshmen from four Italian universities. Methods. This observational cross-sectional study was carried out with an anonymous self-reported paper questionnaire, administered during teaching lectures to university freshmen of the northern (Padua, Bergamo, and Milan campuses) and southern (Palermo campus) parts of the country. Knowledge of STI (a linear numerical score), knowledge of STI prevention (dichotomous variable: yes vs. no) and previous STI occurrence (polytomous variable: "no"; "don't know"; "yes") were the outcomes in the statistical analysis. Results. The final number of freshmen surveyed was 4552 (97.9% response rate). The mean age of respondents was 21.4 ± 2.2 years and most of them (70.3%) were females. A total of 60% of students were in a stable romantic relationship. Only 28% respondents knew the most effective methods to prevent STI (i.e., condom and sexual abstinence), with a slightly higher prevalence of correct answers among females (31.3%) than males (25.8%). Students with history of STIs were 5.1%; they reported referring mostly to their general practitioner (GP) (38.1%) rather than discussing the problem with their partner (13.1%). At multivariable analysis, a significantly higher level of STI knowledge was observed in older students (25+ years of age), biomedical students, and those from a non-nuclear family; lower levels were found among students of the University of Palermo, and those who completed a vocational secondary school education. Those who had less knowledge about the most effective tools to prevent STIs included males, students from the University of Palermo, students registered with educational sciences, economics/political sciences, those of foreign nationality, and those whose fathers had lower educational levels. The risk of contracting a STI was significantly lower only in students not in a stable relationship (relative risk ratio, RRR = 0.67; 95% confidence interval, 95%CI = 0.48; 0.94), whereas such risk was significantly higher in students with higher STI knowledge (RRR = 1.15; 95%CI = 1.08; 1.22). Discussion and Conclusions. University freshmen investigated in this study had poor knowledge of STIs and their prevention. Unexpectedly, those with higher levels of knowledge had an increased risk of STIs. There have been no educational interventions-with good quality and long-term follow-ups-that increased the confidence that such SHE programs could have population level effects. A new high-quality study is therefore recommended to assess the effectiveness of an intervention generating behavioral changes; increasing only STI knowledge may not be sufficient
The scaffolding protein NHERF1 sensitizes EGFR-dependent tumor growth, motility and invadopodia function to gefitinib treatment in breast cancer cells.
Triple negative breast cancer (TNBC) patients cannot be treated with endocrine therapy or targeted therapies due to lack of related receptors. These patients overexpress EGFR but are resistant to Tyrosine Kinase Inhibitors (TKIs) and anti-EGFR therapies. Mechanisms suggested for resistance to TKIs include EGFR independence, mutations and alterations in EGFR and in its downstream signalling pathways. Ligand-induced endocytosis and degradation of EGFR play important roles in the down-regulation of the EGFR signal suggesting that its activity could be regulated by targeting its trafficking. Evidence in normal cells showing that the scaffolding protein Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) can associate with EGFR to regulate its trafficking, led us to hypothesize that NHERF1 expression levels could regulate EGFR trafficking and functional expression in TNBC cells and, in this way, modulate its role in progression and response to treatment.
We investigated the subcellular localization of NHERF1 and its interaction with EGFR in a metastatic basal like TNBC cell model, MDA-MB-231, and the role of forced NHERF1 overexpression and/or stimulation with EGF on the sensitivity to EGFR specific TKI treatment with gefitinib.
Stimulation with EGF induces an interaction of NHERF1 with EGFR to regulate its localization, degradation and function. NHERF1 overexpression is sufficient to drive its interaction with EGFR in non-stimulated conditions, inhibits EGFR degradation and increases its retention time in the plasma membrane. Importantly, NHERF1 overexpression strongly sensitized the cell to the pharmacological inhibition by gefitinib of EGFR-driven growth, motility and invadopodia-dependent ECM proteolysis. The further determination of how the NHERF1-EGFR interaction is regulated may improve our understanding of TNBC resistance to the action of existing anticancer drugs
Levantamento de Chrysodeixis includens na cultura da soja em Palmeiras de Goiás.
A Chrysodeixis includens conhecida como falsa medideira, passou de praga secundária para primária na última década, isso aconteceu pelo aumento populacional nas lavouras causando danos econômicos para os produtores. Na safra de 2013/2014 ocorreram variações de populações muito alta em relação as safras anteriores, seu controle foi incontrolado em alguns casos
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