586 research outputs found
Personalentwicklung von Nachwuchswissenschaftlern. Eine empirische Studie bei Habilitanden des Fachs "Betriebswirtschaftslehre"
Becker FG, Schröder C. Personalentwicklung von Nachwuchswissenschaftlern. Eine empirische Studie bei Habilitanden des Fachs "Betriebswirtschaftslehre". Diskussionspapier der FakultĂ€t fĂŒr Wirtschaftswissenschaften / UniversitĂ€t Bielefeld. Vol 504. Bielefeld: UniversitĂ€t Bielefeld, FakultĂ€t fĂŒr Wirtschaftswissenschaften; 2003
Mutations affecting ligand specificity of the G-protein-coupled receptor for the Saccharomyces cerevisiae tridecapeptide pheromone
AbstractRandom mutations were generated in the G-protein-coupled receptor (Ste2p) for the tridecapeptide pheromone (α-factor) of Saccharomyces cerevisiae. These mutants were screened for variants that responded to antagonists. Because multiple mutations were detected in each mutant receptor recovered from the screen, site-directed mutagenesis was used to create single-site mutant receptors. Three receptors containing mutations F55V, S219P, and S259P were analyzed for their biological responses to various α-factor analogs and for their ligand binding profiles. Cells expressing each of the mutant receptors responded to α-factor as well as or better than wild-type cells in a growth arrest assay. In contrast, the binding of α-factor to the F55V and S219P mutant receptors was at least 10-fold reduced in comparison to wild-type receptor indicating a complex non-linear correlation between binding affinity and biological activity. Cells expressing mutant receptors responded to some normally inactive analogs in biological assays, despite the fact that these analogs had a low affinity for Ste2p. The analysis of these mutant receptors confirms previous findings that the first and sixth transmembrane regions of Ste2p are important for ligand interaction, ligand specificity, and/or receptor activation to initiate the signal transduction pathway. Changes in binding affinity of pheromone analogs to wild-type and mutant receptors indicate that residue 55 of Ste2p is involved with both ligand binding and signal transduction
Potential Melting of Extrasolar Planets by Tidal Dissipation
Tidal heating on Io due to its finite eccentricity was predicted to drive
surface volcanic activity, which was subsequently confirmed by the
spacecrafts. Although the volcanic activity in Io is more
complex, in theory volcanism can be driven by runaway melting in which the
tidal heating increases as the mantle thickness decreases. We show that this
runaway melting mechanism is generic for a composite planetary body with liquid
core and solid mantle, provided that (i) the mantle rigidity, , is
comparable to the central pressure, i.e.
for a body with density , surface gravitational acceleration , and
radius , (ii) the surface is not molten, (iii) tides deposit
sufficient energy, and (iv) the planet has nonzero eccentricity. We calculate
the approximate liquid core radius as a function of ,
and find that more than of the core will melt due to this runaway for
. From all currently confirmed exoplanets, we
find that the terrestrial planets in the L98-59 system are the most promising
candidates for sustaining active volcanism. However, uncertainties regarding
the quality factors and the details of tidal heating and cooling mechanisms
prohibit definitive claims of volcanism on any of these planets. We generate
synthetic transmission spectra of these planets assuming Venus-like atmospheric
compositions with an additional 5, 50, and SO component, which is a
tracer of volcanic activity. We find a preference for a
model with SO with 5-10 transits with for L98-59bcd.Comment: 16 pages, 8 Figures, accepted for publication in Ap
Evidence for Color Dichotomy in the Primordial Neptunian Trojan Population
In the current model of early Solar System evolution, the stable members of
the Jovian and Neptunian Trojan populations were captured into resonance from
the leftover reservoir of planetesimals during the outward migration of the
giant planets. As a result, both Jovian and Neptunian Trojans share a common
origin with the primordial disk population, whose other surviving members
constitute today's trans-Neptunian object (TNO) populations. The cold classical
TNOs are ultra-red, while the dynamically excited "hot" population of TNOs
contains a mixture of ultra-red and blue objects. In contrast, Jovian and
Neptunian Trojans are observed to be blue. While the absence of ultra-red
Jovian Trojans can be readily explained by the sublimation of volatile material
from their surfaces due to the high flux of solar radiation at 5AU, the lack of
ultra-red Neptunian Trojans presents both a puzzle and a challenge to formation
models. In this work we report the discovery by the Dark Energy Survey (DES) of
two new dynamically stable L4 Neptunian Trojans,2013 VX30 and 2014 UU240, both
with inclinations i >30 degrees, making them the highest-inclination known
stable Neptunian Trojans. We have measured the colors of these and three other
dynamically stable Neptunian Trojans previously observed by DES, and find that
2013 VX30 is ultra-red, the first such Neptunian Trojan in its class. As such,
2013 VX30 may be a "missing link" between the Trojan and TNO populations. Using
a simulation of the DES TNO detection efficiency, we find that there are 162
+/- 73 Trojans with Hr < 10 at the L4 Lagrange point of Neptune. Moreover, the
blue-to-red Neptunian Trojan population ratio should be higher than 17:1. Based
on this result, we discuss the possible origin of the ultra-red Neptunian
Trojan population and its implications for the formation history of Neptunian
Trojans
A Compact Multi-Planet System With A Significantly Misaligned Ultra Short Period Planet
We report the discovery of a compact multi-planet system orbiting the
relatively nearby (78pc) and bright () K-star, K2-266 (EPIC248435473).
We identify up to six possible planets orbiting K2-266 with estimated periods
of P = 0.66, P = 6.1, P = 7.8, P = 14.7, P = 19.5, and
P = 56.7 days and radii of R = 3.3 R, 0.646
R, 0.705 R, 2.93 R, 2.73 R, and
0.90 R, respectively. We are able to confirm the planetary nature of
two of these planets (d & e) from analyzing their transit timing variations
( and ),
confidently validate the planetary nature of two other planets (b & c), and
classify the last two as planetary candidates (K2-266.02 & .06). From a
simultaneous fit of all 6 possible planets, we find that K2-266 b's orbit has
an inclination of 75.32 while the other five planets have
inclinations of 87-90. This observed mutual misalignment may indicate
that K2-266 b formed differently from the other planets in the system. The
brightness of the host star and the relatively large size of the sub-Neptune
sized planets d and e make them well-suited for atmospheric characterization
efforts with facilities like the Hubble Space Telescope and upcoming James Webb
Space Telescope. We also identify an 8.5-day transiting planet candidate
orbiting EPIC248435395, a co-moving companion to K2-266.Comment: 18 pages, 12 figures, 7 tables, Accepted for Publication in the
Astronomical Journa
LSST: from Science Drivers to Reference Design and Anticipated Data Products
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5
point-source depth in a single visit in will be (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg with
, and will be imaged multiple times in six bands, ,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to . The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
Measurement of the cosmic ray spectrum above eV using inclined events detected with the Pierre Auger Observatory
A measurement of the cosmic-ray spectrum for energies exceeding
eV is presented, which is based on the analysis of showers
with zenith angles greater than detected with the Pierre Auger
Observatory between 1 January 2004 and 31 December 2013. The measured spectrum
confirms a flux suppression at the highest energies. Above
eV, the "ankle", the flux can be described by a power law with
index followed by
a smooth suppression region. For the energy () at which the
spectral flux has fallen to one-half of its extrapolated value in the absence
of suppression, we find
eV.Comment: Replaced with published version. Added journal reference and DO
Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory
The Auger Engineering Radio Array (AERA) is part of the Pierre Auger
Observatory and is used to detect the radio emission of cosmic-ray air showers.
These observations are compared to the data of the surface detector stations of
the Observatory, which provide well-calibrated information on the cosmic-ray
energies and arrival directions. The response of the radio stations in the 30
to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of
the incoming electric field. For the latter, the energy deposit per area is
determined from the radio pulses at each observer position and is interpolated
using a two-dimensional function that takes into account signal asymmetries due
to interference between the geomagnetic and charge-excess emission components.
The spatial integral over the signal distribution gives a direct measurement of
the energy transferred from the primary cosmic ray into radio emission in the
AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air
shower arriving perpendicularly to the geomagnetic field. This radiation energy
-- corrected for geometrical effects -- is used as a cosmic-ray energy
estimator. Performing an absolute energy calibration against the
surface-detector information, we observe that this radio-energy estimator
scales quadratically with the cosmic-ray energy as expected for coherent
emission. We find an energy resolution of the radio reconstruction of 22% for
the data set and 17% for a high-quality subset containing only events with at
least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO
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