An extrapolation result in the variational setting: improved regularity, compactness, and applications to quasilinear systems

In this paper we consider the variational setting for SPDE on a Gelfand triple $(V, H, V^*)$. Under the standard conditions on a linear coercive pair $(A,B)$, and a symmetry condition on $A$ we manage to extrapolate the classical $L^2$-estimates in time to $L^p$-estimates for some $p>2$ without any further conditions on $(A,B)$. As a consequence we obtain several other a priori regularity results of the paths of the solution. Under the assumption that $V$ embeds compactly into $H$, we derive a universal compactness result quantifying over all $(A,B)$. As an application of the compactness result we prove global existence of weak solutions to a system of second order quasi-linear equations

Counterexamples to maximal regularity for operators in divergence form

In this paper, we present counterexamples to maximal $L^p$-regularity for a parabolic PDE. The example is a second-order operator in divergence form with space and time-dependent coefficients. It is well-known from Lions' theory that such operators admit maximal $L^2$-regularity on $H^{-1}$ under a coercivity condition on the coefficients, and without any regularity conditions in time and space. We show that in general one cannot expect maximal $L^p$-regularity on $H^{-1}(\mathbb{R}^d)$ or $L^2$-regularity on $L^2(\mathbb{R}^d)$

Grenzüberschreitendes Blended-Learning. Zur Förderung interkultureller Kompetenzen in der universitären Französischlehrerausbildung

Damit angehende Fremdsprachenlehrer wissen, wie sie interkulturelle Lern-prozesse bei Schülern anbahnen können, scheint es vor allem notwendig, dass sie selbst interkulturelle Erfahrungen machen und dabei die eigenen Lernprozesse reflektieren. Die Gelegenheiten für Begegnungen mit Mitgliedern des Zielsprachenlandes sind im Rahmen des Studiums jedoch selten. Eine Alternative bieten grenzüberschreitende Seminare, bei denen Teilnehmer aus Partneruniversitäten mit Hilfe internetbasierter Kommunikationsmedien zusammenarbeiten. Im Mittelpunkt des Beitrags steht die Darstellung der Ziele, Inhalte und Methoden eines solchen Seminar

Porträt Weiterbildung Europäische Union

Der Band präsentiert die Europäische Union als Akteurin der Bildungspolitik. Er stellt in bisher einzigartiger Weise Institutionen, Instrumente und politische Leitlinien zusammen, die sich unmittelbar oder mittelbar auf Weiterbildung beziehen. Die einschlägigen Förderprogramme sind dabei sicher das populärste Instrument, die spätestens bis 2010 einen "europäischen Weiterbildungsraum" entstehen lassen. Das Buch richtet sich an alle, die im Bereich der Weiterbildung "europäischer" agieren wollen und hierzu Hintergründe und Praxiswissen benötigen

COVID-19-Related Coagulopathy—Is Transferrin a Missing Link?

SARS-CoV-2 is the causative agent of COVID-19. Severe COVID-19 disease has been associated with disseminated intravascular coagulation and thrombosis, but the mechanisms underlying COVID-19-related coagulopathy remain unknown. The risk of severe COVID-19 disease is higher in males than in females and increases with age. To identify gene products that may contribute to COVID-19-related coagulopathy, we analyzed the expression of genes associated with the Gene Ontology (GO) term “blood coagulation” in the Genotype-Tissue Expression (GTEx) database and identified four procoagulants, whose expression is higher in males and increases with age (ADAMTS13, F11, HGFAC, KLKB1), and two anticoagulants, whose expression is higher in females and decreases with age (C1QTNF1, SERPINA5). However, the expression of none of these genes was regulated in a proteomics dataset of SARS-CoV-2-infected cells and none of the proteins have been identified as a binding partner of SARS-CoV-2 proteins. Hence, they may rather generally predispose individuals to thrombosis without directly contributing to COVID-19-related coagulopathy. In contrast, the expression of the procoagulant transferrin (not associated to the GO term “blood coagulation”) was higher in males, increased with age, and was upregulated upon SARS-CoV-2 infection. Hence, transferrin warrants further examination in ongoing clinic-pathological investigation

: From developing to investigating intercultural competence in practice through oral and written interactions in online exchanges.

La télécollaboration ouvre de nouvelles perspectives pour la communication interculturelle (Thorne & Belz, 2005). Elle donne l'occasion aux futurs enseignants de langues de travailler en collaboration avec des partenaires d'universités inscrites dans d'autres environnements linguistiques et culturels. Nous nous intéressons ici aux dispositifs principalement centrés sur le développement d'une compétence interculturelle communicative (CIC). Ces dispositifs suscitent des échanges fréquents et intensifs sans que les étudiants soient obligés de se déplacer. Mais les recherches ont aussi montré que les contacts peuvent rester superficiels sur le plan interculturel, ou rester bloqués par des situations d'incompréhension (O'Dowd 2006). Pour lever ces obstacles, nous pensons que la qualité du scénario pédagogique et la compétence interculturelle des tuteurs jouent un rôle significatif. Dans le cadre du projet de recherche INFRAL (Interculturel France Allemagne en Ligne) nous avons développé un cours à distance (Blended Learning). Ce cours a été offert durant le semestre d'hiver 2008-09 à plusieurs futur(e)s enseignant(e)s d'allemand et de français afin de leur donner l'occasion de développer leurs compétences interculturelles. Dix étudiant(e)s de l'université de Franche-Comté et neuf étudiant(e)s de l'université de Brême ont régulièrement travaillé ensemble, alternant phases asynchrones dans les blogues et phases synchrones dans des environnements audio-graphique. De part et d'autre les groupes (‘quadrems': 2 brêmois et deux bisontins par groupe) étaient encadrés par un/une tuteur/tutrice sans que celui-ci ou celle-ci soient intervenus dans la communication directe. Les médias de communication employés soutenaient les processus d'apprentissage, de réflexion et de dialogue. Dans notre contribution, nous présentons le dispositif et son scénario pédagogique, le corpus des échanges, et proposons quelques analyses de données des 4 groupes impliqués. Nos questions de recherche visent à éclairer la nature des compétences communicatives interculturelles mises en jeu dans de telles situations, à analyser leurs développements au travers des échanges et productions des participants. Enfin, nous étudions l'influence des tâches, des médias et du scénario pédagogique sur la profondeur des échanges en relation avec la CIC

Tumor site immune markers associated with risk for subsequent basal cell carcinomas.

BackgroundBasal cell carcinoma (BCC) tumors are the most common skin cancer and are highly immunogenic.ObjectiveThe goal of this study was to assess how immune-cell related gene expression in an initial BCC tumor biopsy was related to the appearance of subsequent BCC tumors.Materials and methodsLevels of mRNA for CD3ε (a T-cell receptor marker), CD25 (the alpha chain of the interleukin (IL)-2 receptor expressed on activated T-cells and B-cells), CD68 (a marker for monocytes/macrophages), the cell surface glycoprotein intercellular adhesion molecule-1 (ICAM-1), the cytokine interferon-γ (IFN-γ) and the anti-inflammatory cytokine IL-10 were measured in BCC tumor biopsies from 138 patients using real-time PCR.ResultsThe median follow-up was 26.6 months, and 61% of subjects were free of new BCCs two years post-initial biopsy. Patients with low CD3ε CD25, CD68, and ICAM-1 mRNA levels had significantly shorter times before new tumors were detected (p = 0.03, p = 0.02, p = 0.003, and p = 0.08, respectively). Furthermore, older age diminished the association of mRNA levels with the appearance of subsequent tumors.ConclusionsOur results show that levels of CD3ε, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new BCC tumors

Nanoscale infrared spectroscopy as a non-destructive probe of extraterrestrial samples

Advances in the spatial resolution of modern analytical techniques have tremendously augmented the scientific insight gained from the analysis of natural samples. Yet, while techniques for the elemental and structural characterization of samples have achieved sub-nanometre spatial resolution, infrared spectral mapping of geochemical samples at vibrational 'fingerprint' wavelengths has remained restricted to spatial scales >10 mu m. Nevertheless, infrared spectroscopy remains an invaluable contactless probe of chemical structure, details of which offer clues to the formation history of minerals. Here we report on the successful implementation of infrared near-field imaging, spectroscopy and analysis techniques capable of sub-micron scale mineral identification within natural samples, including a chondrule from the Murchison meteorite and a cometary dust grain (Iris) from NASA's Stardust mission. Complementary to scanning electron microscopy, energy-dispersive X-ray spectroscopy and transmission electron microscopy probes, this work evidences a similarity between chondritic and cometary materials, and inaugurates a new era of infrared nano-spectroscopy applied to small and invaluable extraterrestrial samples

Nanoscale infrared spectroscopy as a non-destructive probe of extraterrestrial samples

Advances in the spatial resolution of modern analytical techniques have tremendously augmented the scientific insight gained from the analysis of natural samples. Yet, while techniques for the elemental and structural characterization of samples have achieved sub-nanometre spatial resolution, infrared spectral mapping of geochemical samples at vibrational 'fingerprint' wavelengths has remained restricted to spatial scales >10 mu m. Nevertheless, infrared spectroscopy remains an invaluable contactless probe of chemical structure, details of which offer clues to the formation history of minerals. Here we report on the successful implementation of infrared near-field imaging, spectroscopy and analysis techniques capable of sub-micron scale mineral identification within natural samples, including a chondrule from the Murchison meteorite and a cometary dust grain (Iris) from NASA's Stardust mission. Complementary to scanning electron microscopy, energy-dispersive X-ray spectroscopy and transmission electron microscopy probes, this work evidences a similarity between chondritic and cometary materials, and inaugurates a new era of infrared nano-spectroscopy applied to small and invaluable extraterrestrial samples

The Grizzly, March 5, 1996

Airband Raises $5,000 • Borsdorf Appointed by Governor Ridge • All About Pledging • Opinions: A Feminist\u27s Point of View; My God ; The Role of the Soul in Evolution; Don\u27t Knock it Unless You\u27ve Tried it; Souls and Science: Where do we Draw the Line?; What it Really Means to be Left Wing; Money Rules the World • Women\u27s Art to be on Display at Berman • Groovy Hippies and Classical Style in Wismer • Faculty Spotlight: Dr. E. Diane Lyle-Smith • Alumna Spotlight: Elizabeth Buckenmyer • Blood Drive Winners • Ortman\u27s Wrestling Career Comes to a Close • Teams Finish Sixth at Conference Championships • Luka Returns as All-American • Team Ranked 10th in U.S.https://digitalcommons.ursinus.edu/grizzlynews/1377/thumbnail.jp