Use of Articulated Transport Systems in the Mining Industry

The work is devoted to the possibility and prospects of the use of all-wheels drive articulated transport systems in the mining complex. A comparative analysis of the traditional methods of exporting minerals in open pit mining and the method of using active trailed elements are given. The trailer has a load factor several times higher than the same rate for mining dump trucks. The use of an active trailer makes it possible to reduce the mass of the tractor and trailer by almost 40 tons and increase the specific power of the road train. © Published under licence by IOP Publishing Ltd

Developing Facilities of Screen Arts in Artistic Education and Aesthetic Education of Pupils

При финансовой поддержке Российского гуманитарного научного фонда, проект № 08-06-14134

Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer.

We hypothesized that aberrations activating epidermal growth factor receptor (EGFR) via dimerization would be more sensitive to anti-dimerization agents (e.g., cetuximab). EGFR exon 19 abnormalities (L747_A750del; deletes amino acids LREA) respond to reversible EGFR kinase inhibitors (TKIs). Exon 20 in-frame insertions and/or duplications (codons 767 to 774) and T790M mutations are clinically resistant to reversible/some irreversible TKIs. Their impact on protein function/therapeutic actionability are not fully elucidated.In our study, the index patient with non-small cell lung cancer (NSCLC) harbored EGFR D770_P772del_insKG (exon 20). A twenty patient trial (NSCLC cohort) (cetuximab-based regimen) included two participants with EGFR TKI-resistant mutations ((i) exon 20 D770>GY; and (ii) exon 19 LREA plus exon 20 T790M mutations). Structural modeling predicted that EGFR exon 20 anomalies (D770_P772del_insKG and D770>GY), but not T790M mutations, stabilize the active dimer configuration by increasing the interaction between the kinase domains, hence sensitizing to an agent preventing dimerization. Consistent with predictions, the two patients harboring D770_P772del_insKG and D770>GY, respectively, responded to an EGFR antibody (cetuximab)-based regimen; the T790M-bearing patient showed no response to cetuximab combined with erlotinib. In silico modeling merits investigation of its ability to optimize therapeutic selection based on structural/functional implications of different aberrations within the same gene

Functional condition of cardiovascular system of children with bronchial asthma

The aim: to judge the heart-vascular system of children suffering from bronchial asthma of different severity level. Materials and methods: 95 children (age 7-12) affected by bronchial asthma were examined, among them there were 68 boys (71,5%) and 27 girls (28,5%). Examining of cardiovascular system was held according to the data of objective checking, monitoring of arterial pressure (AP), electrocardiogram (ECG), echocardiography (ECHO-KG). The state of vegetative nervous system and initial vegetative tonus was detected with a help of scoring table of A.B. Vein (2000). As a result of the research it is established that all the children have changes of cardiovascular system in the form of heart rate changes, vegetovascular dysfunctions. As a rule all these dysfunctions do not depend on how heavy the BA is. Small anomalies of heart, dysfunction of valve apparatus, a functioning foramen oval can be frequently found in the echocardiography (ECHO-KG)Цель: оценить состояние сердечно-сосудистой системы у детей, страдающих бронхиальной астмой различной степени тяжести. Материалы и методы: обследовано 95 детей в возрасте 7-12 лет (средний возраст 10 ± 1,69), больных бронхиальной астмой различной степени тяжести. Из них 68 (71,5%) мальчиков и 27 (28,5%) девочек. Проводили оценку состояния сердечно-сосудистой системы по данным объективного осмотра, мониторингу артериального давления (АД), ЭКГ, Эхо-КГ. Состояние вегетативной нервной системы и исходного вегетативного тонуса определяли с помощью оценочных таблиц А.В. Вейна (2000г.). В результате проведенных исследований установлено, что независимо от тяжести течения БА, все дети имеют отклонения со стороны сердечно-сосудистой системы в виде нарушений сердечного ритма, вегетативно-сосудистых дисфункций. Настой находкой при эхокардиографии (ЭХО-КГ) являются малые аномалии сердца, дисфункции клапанного аппарата, функционирующее овальное окно

Позднеплейстоценовое оледенение и отступание ледникового покрова на шельфе Южно-Оркнейского плато, Западная Антарктика

The research aims to provide insight into reconstruction of the Late Pleistocene glaciations and ice retreat that followed the Last Glacial Maximum. The study is based on multi-channel seismic profiling and multibeam survey conducted on the shelf during the 63-rd Russian Antarctic Expedition (2018) on RV «Akademik Alexander Karpinsky». The 560-channel, 7000-m-long streamer and the Atlas Hydrosweep MD-3/30 multibeam echo-sounder were used for seismic and multibeam survey, respectively. In addition, previously collected seismic data available from the Antarctic Seismic Data Library System and bathymetry data from the «International Bathymetry Chart of the Southern Ocean» (IBCSO) Project were involved for interpretation. The multibeam survey was carried out within the Signy Trough and its flanks with depths ranging from 180 to 400 m, and covered the area of about 1500 km2. The data were collected along 43 profiles spaced at 750 m to ensure enough overlap between swaths. Variety of submarine glacial landforms formed by grounded ice was identified on shelf of the South Orkney Plateau with use of seismic and multibeam data. The most prominent of these features is the large terminal moraine at the middle shelf (previously described as the mid-shelf break) marking the greatest ice extent at the LGM. Oceanward of the large terminal moraine, the plateau-like feature (delineated by 350 and 425 m isobaths) with relatively steep outer slope is recognized from seismic data and interpreted as the distal terminal moraine formed during the pre-LGM Pleistocene glaciation. Within the Signy Trough, submarine glacial landforms mapped by multibeam survey, reflect ice retreat after the LGM; these landforms include: subglacial lineation at the western flank of the northern Signy Trough indicating fast flowing grounded ice, transverse recessional moraine ridges, lateral shear moraine on the western flank and lateral marginal moraine on the eastern flank of the Trough, two grounding zone wedges, streamlined features (drumlins) and an ice-proximal fan (presumably). The end moraine was also identified in the eastern flank of Signy Trough. It is thought to be formed due to ice (outlet glacier) re-advance during the Antarctic Cold Reversal. Numerous iceberg plough-marks were observed at least down to 370 m water depths.По данным сейсмического профилирования и детальной съёмки с помощью многолучевого эхолота на шельфе Южно-Оркнейского плато идентифицированы подводные ледниковые формы рельефа, которые маркируют распространение ледникового покрова в периоды четвертичных оледенений и этапы его отступания в позднем плейстоцене. Предполагается, что максимальное распространение ледника с его налеганием на дно произошло в один из периодов похолодания плейстоцена. Во время последнего ледникового максимума ледник достигал среднего шельфа и сформировал крупную конечную морену. После этого началось его отступание, которое происходило неравномерно. В период Антарктического холодного реверса в районе долины Сигню установлено повторное наступание ледника

CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS AND SOME CYTOKINES IN BLOOD OF WOMEN DURING MENOPAUSAL THERAPY

It has been shown that the influence of hormonal and non-hormonal therapy of menopausal syndrome upon immune profile may be variable, and the results of appropriate studies may be often contradictory. The aim of this work was to investigate the influence of hormonal and non-hormonal therapy in menopausal syndrome upon serum levels of some immunoregulatory proteins, i.e., alpha2-macroglobulin (a2-MG), pregnancy-associated alpha 2-glycoprotein (PAG), contents of some related cytokines (IL-6, IL-8, TNFα, IFNγ, IL-2) as well as VEGF amounts. Administration of menopausal hormone treatment and nonhormonal therapy was associated with reduced IL-6 levels in serum, regardless of treatment duration, or type of drug applied. We have found a statistically significant decrease of IL-8 serum levels in the course of dynamic monitoring in the women taking a menopausal hormone preparation containing 1 mg of 17β-estradiol and 5 mg dydrogesterone, and a non-hormonal drug containing genistein (60 mg) for 3-6 months. The levels of VEGF demonstrated high individual variability during therapy of menopausal syndrome. Serum concentrations of immunoregulatory a2-MG were stable in climacteric syndrome, and did not differ from normal values. However, the content of PAG, a known immunosuppressive protein, was increased 3-4 times in serum of 33-50% of the women receiving menopausal hormonal therapy, regardless of progestogen dose (5 or 10 mg dydrogesterone), and duration of its use. These findings suggest a need for individualized drug selection in order to minimize a risk of immunodeficiency conditions in the patients receiving hormone therapy of menopausal syndrome

Optimized properties of live vaccine influenza reassortant strains obtained by reverse genetics

Classical reassortment in developing chicken eggs is a well-established technique for obtaining LAIV strains. Naturally generated reassortant vaccine strains are characterized by high reproductive capacity, genetically stable characteristics of temperature sensitivity and cold resistance, which correspond to the characteristics of the MDV involved in crossing with the epidemic virus. Along with antigenic relevance, natural reassortment ensures attenuation of vaccine strains, good reproduction capacity in upper respiratory tract cells and inability to reproduction in the lower respiratory tract. With classical reassortment, the speed and efficiency of obtaining vaccine reassortants largely depend on the properties of epidemic virus, and therefore cannot be stable. The potential of reverse genetics is attractive because it allows to obtain vaccine reassortants quickly and efficiently, reduce the likelihood of spontaneous mutations; however, the vaccine strain is deprived of the advantages of natural selection, in which the most viable clones are selected. This study presents the results of comparatively assessed A(H3N2) LAIVs obtained in parallel by classical reassortment and reverse genetics according to criteria confirming that vaccine strains inherit the necessary properties that guarantee their harmlessness and high reproduction in chicken embryos. Strains for LAIV obtained by both methods retained all attenuating mutations inherited from the MDV, were highly reproductive at the optimal temperature, with temperature sensitivity corresponded to the MDV. However, strains obtained by reverse genetics, was observed to have partial loss of cold resistance in comparison with that of the MDV and classical reassortants. Reduced cold adaptation may negatively affect vaccine effectiveness. It is important that after several additional passages in chicken embryos at low temperature, the cold resistance of the vaccine strain, assembled by reverse genetics, was increased. Credibly that cold resistance is a phenotypic trait, the degree of manifestation of which depends on the temperature conditions of virus multiplication. The selective factor of reduced incubation temperature is missing in reverse genetics. In order for the cold-adapted phenotype to be fully realized, additional passages at low temperature of RG-reassortants are necessary. Thus, the reverse genetics method using plasmid technology allows to effectively prepare reassortant strains for LAIV. An important stage in obtaining vaccine strains using genetic engineering techniques should be the control of their cold-adapted phenotype and its optimization by additional passages at low temperature

Quality education – guarantee of high-quality practical activity of a doctor. the electronic study guide «Nebulizer therapy in the practice of a local pediatrician».

This electronic study guide is intended for pediatric students, residents. pediatricians, students of DPO and CME courses, and can also be used in the process of mastering the educational programs of residency and postgraduate studies in the specialty "Pediatrics". This manual covers topics such as general issues of inhalation therapy (its advantages and disadvantages, the main indicators of the operation of inhalation devices), diseases for which nebulizer therapy is used, drugs recommended for nebulization and algorithms for the use of nebulized drugs. means, rules and technique of inhalation through a nebulizer. The use of this manual contributes to the consolidation of the professional competence of the district pediatrician in the field of diagnosis and treatment of major respiratory diseases in children.Электронное учебное пособие предназначено для студентов педиатрического факультета, ординаторов. врачей педиатров, слушателей курсов ДПО и НМО, а также может быть использовано в процессе освоения образовательных программ ординатуры и аспирантуры по специальности «Педиатрия». В пособии рассматриваются такие темы, как общие вопросы ингаляционной терапии (ее преимущества и недостатки, основные показатели работы ингаляционных устройств), заболевания, при которых применяется небулайзерная терапия, препараты, рекомендованные для небулизации и алгоритмы применения небулизированных лекарственных средств, правила и техника проведения ингаляций через небулайзер. Использование данного пособия способствует закреплению профессиональных компетенций участкового педиатра в области диагностики и лечения основных заболеваний органов дыхания у детей

Predicting the development of cardiovascular disorders in children with bronchial asthma

The article gives the data about a condition of cardiovascular system of 7-12 year-old children, suffering from bronchial asthma (BA).As a result of the research it is established that all the children have changes of cardiovascular system in the form of heart rate changes, vegetovascular dysfunctions, small anomalies of heart, dysfunction of valve apparatus, a functioning foramen oval. As a rule all these dysfunctions do not depend on how heavy the BA is. According to the results obtained, a decisive rule for predicting cardiovascular disorders in children with asthma was obtained.В статье приводятся данные о состоянии сердечно-сосудистой системы у детей 7-12 лет, страдающих бронхиальной астмой (БА). В результате проведенных исследований установлено, что независимо от тяжести течения БА, все дети имеют отклонения со стороны сердечно-сосудистой системы в виде нарушений сердечного ритма, вегетативно-сосудистых дисфункций, малые аномалии сердца, дисфункции клапанного аппарата, функционирующее овальное окно. По данным полученных результатов разработано решающее правило прогноза кардиоваскулярных нарушений у детей с БА