163 research outputs found
Transient radio lines from axion miniclusters and axion stars
Gravitationally bound clumps of dark matter axions in the form of âminiclustersâ or even denser âaxion starsâ can generate strong radio signals through axion-photon conversion when encountering highly magnetized neutron star magnetospheres. We systematically study encounters of axion clumps with neutron stars and characterize the axion infall, conversion and the subsequent propagation of the photons. We show that the high density and low escape velocity of the axion clumps lead to strong, narrow, and temporally characteristic transient radio lines with an expected duration varying from seconds to months. Our work comprises the first end-to-end modeling pipeline capable of characterizing the radio signal generated during these transient encounters, quantifying the typical brightness, anisotropy, spectral width, and temporal evolution of the radio flux. The methods developed here may prove essential in developing dedicated radio searches for transient radio lines arising from miniclusters and axion stars
Evolution of the spin of the nucleon
We compare momentum sum rules from unpolarized electroproduction and the spin
sum rule for in polarized electroproduction, and their evolution in
the framework of the operator product expansion. Second order effects in
are included. We show that in comparing the evolution of the spin
sum rule with the momentum sum rule one is not overly sensitive to using first
or second order, even when going to the extreme low limit in which gluons
carry no momentum. Our results show that in that limit there is no need to
include any contribution of strange quarks.Comment: 17 pages RevTeX, 4 uuencoded figure
A model for the dependence of polarized structure functions
We present an update of a phenomenological model for the spin dependent
structure functions of the proton and neutron. This model is based
on a broken SU(6) wavefunction parametrized by the unpolarized structure
functions. The two free parameters of the model are choosen to fulfill the
Bjorken and Ellis--Jaffe sum rules. The model respects isospin symmetry and has
zero strange sea polarization. Using new values for from hyperon beta
decay the resulting dependent asymmetries are in perfect agreement
with the existing data. Therefore we do not see any evidence for a ``spin
crisis''. With two choices for the dependence of and
is predicted and shown to be small for both cases.Comment: 18 pages and 11 figures as uudecoded ps file
Dark Energy and Gravity
I review the problem of dark energy focusing on the cosmological constant as
the candidate and discuss its implications for the nature of gravity. Part 1
briefly overviews the currently popular `concordance cosmology' and summarises
the evidence for dark energy. It also provides the observational and
theoretical arguments in favour of the cosmological constant as the candidate
and emphasises why no other approach really solves the conceptual problems
usually attributed to the cosmological constant. Part 2 describes some of the
approaches to understand the nature of the cosmological constant and attempts
to extract the key ingredients which must be present in any viable solution. I
argue that (i)the cosmological constant problem cannot be satisfactorily solved
until gravitational action is made invariant under the shift of the matter
lagrangian by a constant and (ii) this cannot happen if the metric is the
dynamical variable. Hence the cosmological constant problem essentially has to
do with our (mis)understanding of the nature of gravity. Part 3 discusses an
alternative perspective on gravity in which the action is explicitly invariant
under the above transformation. Extremizing this action leads to an equation
determining the background geometry which gives Einstein's theory at the lowest
order with Lanczos-Lovelock type corrections. (Condensed abstract).Comment: Invited Review for a special Gen.Rel.Grav. issue on Dark Energy,
edited by G.F.R.Ellis, R.Maartens and H.Nicolai; revtex; 22 pages; 2 figure
Fitting the integrated Spectral Energy Distributions of Galaxies
Fitting the spectral energy distributions (SEDs) of galaxies is an almost
universally used technique that has matured significantly in the last decade.
Model predictions and fitting procedures have improved significantly over this
time, attempting to keep up with the vastly increased volume and quality of
available data. We review here the field of SED fitting, describing the
modelling of ultraviolet to infrared galaxy SEDs, the creation of
multiwavelength data sets, and the methods used to fit model SEDs to observed
galaxy data sets. We touch upon the achievements and challenges in the major
ingredients of SED fitting, with a special emphasis on describing the interplay
between the quality of the available data, the quality of the available models,
and the best fitting technique to use in order to obtain a realistic
measurement as well as realistic uncertainties. We conclude that SED fitting
can be used effectively to derive a range of physical properties of galaxies,
such as redshift, stellar masses, star formation rates, dust masses, and
metallicities, with care taken not to over-interpret the available data. Yet
there still exist many issues such as estimating the age of the oldest stars in
a galaxy, finer details ofdust properties and dust-star geometry, and the
influences of poorly understood, luminous stellar types and phases. The
challenge for the coming years will be to improve both the models and the
observational data sets to resolve these uncertainties. The present review will
be made available on an interactive, moderated web page (sedfitting.org), where
the community can access and change the text. The intention is to expand the
text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics &
Space Scienc
Polarized Parton Distributions in the Nucleon
The distribution of the spin of the nucleon among its constituents can be
parametrized in the form of polarized parton distribution functions for quarks
and gluons. Using all available data on the polarized structure function
, we determine these distributions both at leading and
next-to-leading order in perturbation theory. We suggest three different,
equally possible scenarios for the polarized gluon distribution, which is found
to be only loosely constrained by current experimental data. We examine various
possibilities of measuring polarized parton distributions at future
experiments.Comment: 18 pages, LATEX, 6 figures available as .uu fil
Polarized deep-inelastic scattering from nuclei: a relativistic approach.
We discuss spin-dependent, deep-inelastic scattering from nuclei within a covariant framework. In the relativistic impulse approximation this is described in terms of the amplitude for forward, virtual-photon scattering from an off-mass-shell nucleon. The general structure of the off-shell nucleon hadronic tensor is derived, and the leading behavior of the off-shell nucleon structure functions computed in the Bjorken limit. The formalism, which is valid for nucleons bound inside nuclei with spin 1/2 or 1, is applied to the case of the deuteron.Piller, G. ; Melnitchouk, W. ; Thomas, A.W
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Teaching open and reproducible scholarship: a critical review of the evidence base for current pedagogical methods and their outcomes.
YesIn recent years, the scientific community has called for improvements in the credibility, robustness and reproducibility of research, characterized by increased interest and promotion of open and transparent research practices. While progress has been positive, there is a lack of consideration about how this approach can be embedded into undergraduate and postgraduate research training. Specifically, a critical overview of the literature which investigates how integrating open and reproducible science may influence student outcomes is needed. In this paper, we provide the first critical review of literature surrounding the integration of open and reproducible scholarship into teaching and learning and its associated outcomes in students. Our review highlighted how embedding open and reproducible scholarship appears to be associated with (i) students' scientific literacies (i.e. students' understanding of open research, consumption of science and the development of transferable skills); (ii) student engagement (i.e. motivation and engagement with learning, collaboration and engagement in open research) and (iii) students' attitudes towards science (i.e. trust in science and confidence in research findings). However, our review also identified a need for more robust and rigorous methods within pedagogical research, including more interventional and experimental evaluations of teaching practice. We discuss implications for teaching and learning scholarship.UKRI/ESRC rapid call grant, ealth Research Board Applying Researchinto Policy and Practice Fellowship, John Templeton Foundation (grant ID: 62631), Northern Ireland Department for the Economy Research Studentshi
Analysis of shared heritability in common disorders of the brain
Paroxysmal Cerebral Disorder
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Background:
In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.
Methods:
This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein â„75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mgâ800 mg (depending on weight) given intravenously. A second dose could be given 12â24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936).
Findings:
Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21â550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76â0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12â1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77â0·92; p<0·0001).
Interpretation:
In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids.
Funding:
UK Research and Innovation (Medical Research Council) and National Institute of Health Research
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