220 research outputs found
Predictions from Quantum Cosmology
The world view suggested by quantum cosmology is that inflating universes
with all possible values of the fundamental constants are spontaneously created
out of nothing. I explore the consequences of the assumption that we are a
`typical' civilization living in this metauniverse. The conclusions include
inflation with an extremely flat potential and low thermalization temperature,
structure formation by topological defects, and an appreciable cosmological
constant.Comment: (revised version), 15 page
Categorizing Different Approaches to the Cosmological Constant Problem
We have found that proposals addressing the old cosmological constant problem
come in various categories. The aim of this paper is to identify as many
different, credible mechanisms as possible and to provide them with a code for
future reference. We find that they all can be classified into five different
schemes of which we indicate the advantages and drawbacks.
Besides, we add a new approach based on a symmetry principle mapping real to
imaginary spacetime.Comment: updated version, accepted for publicatio
A model for the dependence of polarized structure functions
We present an update of a phenomenological model for the spin dependent
structure functions of the proton and neutron. This model is based
on a broken SU(6) wavefunction parametrized by the unpolarized structure
functions. The two free parameters of the model are choosen to fulfill the
Bjorken and Ellis--Jaffe sum rules. The model respects isospin symmetry and has
zero strange sea polarization. Using new values for from hyperon beta
decay the resulting dependent asymmetries are in perfect agreement
with the existing data. Therefore we do not see any evidence for a ``spin
crisis''. With two choices for the dependence of and
is predicted and shown to be small for both cases.Comment: 18 pages and 11 figures as uudecoded ps file
SPIN-DEPENDENT NUCLEAR STRUCTURE FUNCTIONS: GENERAL APPROACH WITH APPLICATION TO THE DEUTERON
We study deep-inelastic scattering from polarized nuclei within a covariant
framework. A clear connection is established between relativistic and
non-relativistic limits, which enables a rigorous derivation of convolution
formulae for the spin-dependent nuclear structure functions g_1^A and g_2^A in
terms of off-mass-shell extrapolations of polarized nucleon structure
functions, g_1^N and g_2^N. Approximate expressions for g_{1,2}^A are obtained
by expanding the off-shell g_{1,2}^N about their on-shell limits. As an
application of the formalism we consider nuclear effects in the deuteron,
knowledge of which is necessary to obtain accurate information on the
spin-dependent structure functions of the neutron.Comment: 26 pages RevTeX, 9 figures available upon reques
MCMC implementation for Bayesian hidden semi-Markov models with illustrative applications
Copyright © Springer 2013. The final publication is available at Springer via http://dx.doi.org/10.1007/s11222-013-9399-zHidden Markov models (HMMs) are flexible, well established models useful in a diverse range of applications.
However, one potential limitation of such models lies in their inability to explicitly structure the holding times of each hidden state. Hidden semi-Markov models (HSMMs) are more useful in the latter respect as they incorporate additional temporal structure by explicit modelling of the holding times. However, HSMMs have generally received less attention in the literature, mainly due to their intensive computational requirements. Here a Bayesian implementation of HSMMs is presented. Recursive algorithms are proposed in conjunction with Metropolis-Hastings in such a way as to avoid sampling from the distribution of the hidden state sequence in the MCMC sampler. This provides a computationally tractable estimation framework for HSMMs avoiding the limitations associated with the conventional EM algorithm regarding model flexibility. Performance of the proposed implementation is demonstrated through simulation experiments as well as an illustrative application relating to recurrent failures in a network of underground water pipes where random effects are also included into the HSMM to allow for pipe heterogeneity
Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients
Objective To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs. Methods We conducted a case-control genome-wide association study of autosomal genotypes, including Class I and II human leukocyte antigen (HLA) alleles, in 323 cases and 1,321 drug-tolerant controls from epilepsy cohorts of northern European and Han Chinese descent. Results from each cohort were meta-analyzed. Results We report an association between a rare variant in the complement factor H–related 4 (CFHR4) gene and phenytoin-induced MPE in Europeans (p = 4.5 × 10–11; odds ratio [95% confidence interval] 7 [3.2–16]). This variant is in complete linkage disequilibrium with a missense variant (N1050Y) in the complement factor H (CFH) gene. In addition, our results reinforce the association between HLA-A*31:01 and carbamazepine hypersensitivity. We did not identify significant genetic associations with MPE among Han Chinese patients. Conclusions The identification of genetic predictors of MPE in CFHR4 and CFH, members of the complement factor H–related protein family, suggest a new link between regulation of the complement system alternative pathway and phenytoin-induced hypersensitivity in European-ancestral patients
Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19
BACKGROUND REGEN-COV (previously known as REGN-COV2), a combination of the monoclonal antibodies casirivimab and imdevimab, has been shown to markedly reduce the risk of hospitalization or death among high-risk persons with coronavirus disease 2019 (Covid-19). Whether subcutaneous REGEN-COV prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent Covid-19 in persons at high risk for infection because of household exposure to a person with SARS-CoV-2 infection is unknown. METHODS We randomly assigned, in a 1:1 ratio, participants (=12 years of age) who were enrolled within 96 hours after a household contact received a diagnosis of SARSCoV- 2 infection to receive a total dose of 1200 mg of REGEN-COV or matching placebo administered by means of subcutaneous injection. At the time of randomization, participants were stratified according to the results of the local diagnostic assay for SARS-CoV-2 and according to age. The primary efficacy end point was the development of symptomatic SARS-CoV-2 infection through day 28 in participants who did not have SARS-CoV-2 infection (as measured by reverse-transcriptase- quantitative polymerase-chain-reaction assay) or previous immunity (seronegativity). RESULTS Symptomatic SARS-CoV-2 infection developed in 11 of 753 participants in the REGEN-COV group (1.5%) and in 59 of 752 participants in the placebo group (7.8%) (relative risk reduction [1 minus the relative risk], 81.4%; P104 copies per milliliter) was shorter (0.4 weeks and 1.3 weeks, respectively). No dose-limiting toxic effects of REGEN-COV were noted. CONCLUSIONS Subcutaneous REGEN-COV prevented symptomatic Covid-19 and asymptomatic SARS-CoV-2 infection in previously uninfected household contacts of infected persons. Among the participants who became infected, REGEN-COV reduced the duration of symptomatic disease and the duration of a high viral load
Two Types of Planning in Neighborhoods
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68338/2/10.1177_0739456X8400300209.pd
Relativistic Laser-Matter Interaction and Relativistic Laboratory Astrophysics
The paper is devoted to the prospects of using the laser radiation
interaction with plasmas in the laboratory relativistic astrophysics context.
We discuss the dimensionless parameters characterizing the processes in the
laser and astrophysical plasmas and emphasize a similarity between the laser
and astrophysical plasmas in the ultrarelativistic energy limit. In particular,
we address basic mechanisms of the charged particle acceleration, the
collisionless shock wave and magnetic reconnection and vortex dynamics
properties relevant to the problem of ultrarelativistic particle acceleration.Comment: 58 pages, 19 figure
Measurement of the - and -Dependence of the Asymmetry on the Nucleon
We report results for the virtual photon asymmetry on the nucleon from
new Jefferson Lab measurements. The experiment, which used the CEBAF Large
Acceptance Spectrometer and longitudinally polarized proton (NH) and
deuteron (ND) targets, collected data with a longitudinally
polarized electron beam at energies between 1.6 GeV and 5.7 GeV. In the present
paper, we concentrate on our results for and the related ratio
in the resonance and the deep inelastic regions for our lowest
and highest beam energies, covering a range in momentum transfer from
0.05 to 5.0 GeV and in final-state invariant mass up to about 3 GeV.
Our data show detailed structure in the resonance region, which leads to a
strong --dependence of for below 2 GeV. At higher , a
smooth approach to the scaling limit, established by earlier experiments, can
be seen, but is not strictly --independent. We add
significantly to the world data set at high , up to . Our data
exceed the SU(6)-symmetric quark model expectation for both the proton and the
deuteron while being consistent with a negative -quark polarization up to
our highest . This data setshould improve next-to-leading order (NLO) pQCD
fits of the parton polarization distributions.Comment: 7 pages LaTeX, 5 figure
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