1,306 research outputs found
Showcasing HH production: Benchmarks for the (HL-)LHC
Current projections suggest that the LHC will have only limited sensitivity
to di-Higgs production in the Standard Model (SM), possibly even after the
completion of its high luminosity phase. Multi-Higgs final states play a
fundamental role in many extensions of the SM as they are intrinsically
sensitive to modifications of the Higgs sector. Therefore, any new observation
in multi-Higgs final states could be linked to a range of beyond the SM (BSM)
phenomena that are not sufficiently addressed by the SM. Extensions of the
Higgs sector typically lead to new phenomenological signatures in multi-Higgs
final states that are vastly different from the SM expectation. In this work,
we provide a range of signature-driven benchmark points for resonant and
non-resonant BSM di-Higgs production that motivate non-SM kinematic
correlations and multi-fermion discovery channels. Relying on theoretically
well-motivated assumptions, special attention is devoted to the particular case
where the presence of new physics will dominantly manifest itself in
multi-Higgs final states
High scale impact in alignment and decoupling in two-Higgs doublet models
The two-Higgs doublet model (2HDM) provides an excellent benchmark to study
physics beyond the Standard Model (SM). In this work we discuss how the
behaviour of the model at high energy scales causes it to have a scalar with
properties very similar to those of the SM -- which means the 2HDM can be seen
to naturally favor a decoupling or alignment limit. For a type II 2HDM, we show
that requiring the model to be theoretically valid up to a scale of 1 TeV, by
studying the renormalization group equations (RGE) of the parameters of the
model, causes a significant reduction in the allowed magnitude of the quartic
couplings. This, combined with -physics bounds, forces the model to be
naturally decoupled. As a consequence, any non-decoupling limits in type II,
like the wrong-sign scenario, are excluded. On the contrary, even with the very
constraining limits for the Higgs couplings from the LHC, the type I model can
deviate substantially from alignment. An RGE analysis similar to that made for
type II shows, however, that requiring a single scalar to be heavier than about
500 GeV would be sufficient for the model to be decoupled. Finally, we show
that not only a 2HDM where the lightest of the CP-even scalars is the 125 GeV
one does not require new physics to be stable up to the Planck scale but this
is also true when the heavy CP-even Higgs is the 125 GeV and the theory has no
decoupling limit for the type I model.Comment: 28 pages, 19 figure
Theory of phase-locking in generalized hybrid Josephson junction arrays
A recently proposed scheme for the analytical treatment of the dynamics of
two-dimensional hybrid Josephson junction arrays is extended to a class of
generalized hybrid arrays with ''horizontal'' shunts involving a capacitive as
well as an inductive component. This class of arrays is of special interest,
because the internal cell coupling has been shown numerically to favor in-phase
synchronization for certain parameter values. As a result, we derive limits on
the circuit design parameters for realizing this state. In addition, we obtain
formulas for the flux-dependent frequency including flux-induced switching
processes between the in-phase and anti-phase oscillation regime. The treatment
covers unloaded arrays as well as arrays shunted via an external load.Comment: 24 pages, REVTeX, 5 Postscript figures, Subm. to Phys. Rev.
Anti-phase locking in a two-dimensional Josephson junction array
We consider theoretically phase locking in a simple two-dimensional Josephson
junction array consisting of two loops coupled via a joint line transverse to
the bias current. Ring inductances are supposed to be small, and special
emphasis is taken on the influence of external flux. Is is shown, that in the
stable oscillation regime both cells oscillate with a phase shift equal to
(i.e. anti-phase). This result may explain the low radiation output
obtained so far in two-dimensional Josephson junction arrays experimentally.Comment: 11 pages, REVTeX, 1 Postscript figure, Subm. to Appl. Phys. Let
Assessing the significance of knockout cascades in metabolic networks
Complex networks have been shown to be robust against random structural
perturbations, but vulnerable against targeted attacks. Robustness analysis
usually simulates the removal of individual or sets of nodes, followed by the
assessment of the inflicted damage. For complex metabolic networks, it has been
suggested that evolutionary pressure may favor robustness against reaction
removal. However, the removal of a reaction and its impact on the network may
as well be interpreted as selective regulation of pathway activities,
suggesting a tradeoff between the efficiency of regulation and vulnerability.
Here, we employ a cascading failure algorithm to simulate the removal of single
and pairs of reactions from the metabolic networks of two organisms, and
estimate the significance of the results using two different null models:
degree preserving and mass-balanced randomization. Our analysis suggests that
evolutionary pressure promotes larger cascades of non-viable reactions, and
thus favors the ability of efficient metabolic regulation at the expense of
robustness
Intrinsic mechanism of phase locking in two-dimensional Josephson junction networks in presence of an external magnetic field
We present numerical simulations of the dynamics of two-dimensional Josephson
junction arrays to study the mechanism of mutual phase locking. We show that in
the presence of an external magnetic field two mechanisms are playing a role in
phase locking: feedback through the external load and internal coupling between
rows due to microwave currents induced by the field. We have found the
parameter values (junction capacitance, cell loop inductance, impedance of the
external load) for which the interplay of both these mechanisms leads to the
in-phase solution. The case of unshunted arrays is discussed as well.Comment: 13 pages, incl. 6 ps figures, Subm. to Europhysics Letter
Transcription in the absence of histone H3.3
Di- and trimethylation of histone H3 lysine 4 (H3K4me2 and H3K4me3) are hallmarks of chromatin at active genes. The major fraction of K4-methylated histone H3 is the variant H3 (termed H3.3 in Drosophila), which replaces canonical H3 (H3.2) in transcribed genes. Here, we genetically address the in vivo significance of such K4 methylation by replacing wild-type H3.3 with a mutant form (H3.3K4A) that cannot be methylated. We monitored the transcription that occurs in response to multiple well-described signaling pathways. Surprisingly, the transcriptional outputs of these pathways remain intact in H3.3K4A mutant cells. Even the complete absence of both H3.3 genes does not noticeably affect viability or function of cells: double mutant animals are viable but sterile. Fertility can be rescued by K4-containing versions of H3.3, but not with mutant H3.3 (H3.3K4A) or with canonical H3.2. Together, these data suggest that in Drosophila, presence of H3.3K4me in the chromatin of active genes is dispensable for successful transcription in most cells and only plays an important role in reproductive tissues
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A framework for gene mapping in wheat demonstrated using the Yr7 yellow rust resistance gene
We used three approaches to map the yellow rust resistance gene Yr7 and identify associated SNPs in wheat. First, we used a traditional QTL mapping approach using a double haploid (DH) population and mapped Yr7 to a low-recombination region of chromosome 2B. To fine map the QTL, we then used an association mapping panel. Both populations were SNP array genotyped allowing alignment of QTL and genome-wide association scans based on common segregating SNPs. Analysis of the association panel spanning the QTL interval, narrowed the interval down to a single haplotype block. Finally, we used mapping-by-sequencing of resistant and susceptible DH bulks to identify a candidate gene in the interval showing high homology to a previously suggested Yr7 candidate and to populate the Yr7 interval with a higher density of polymorphisms. We highlight the power of combining mapping-by-sequencing, delivering a complete list of gene-based segregating polymorphisms in the interval with the high recombination, low LD precision of the association mapping panel. Our mapping-by-sequencing methodology is applicable to any trait and our results validate the approach in wheat, where with a near complete reference genome sequence, we are able to define a small interval containing the causative gene
Sleep in the human aging process and circadian sleep rhythm disruptions
The aging process is often related to sleeping difficulties, often due to changes in circadian rhythms. The circadian timing system is centered in the suprachiasmatic nucleus - the master biological clock - which synchronizes the rhythm of oscillators throughout the body, including the sleep-wake cycle. This affects the time, duration and quality of sleep according to the development and aging process, under external and internal influences. This review addresses the human circadian timing system, including endogenous and exogenous influences on circadian rhythms, their age-related particularities, as well as the repercussions of circadian misalignment in neurodegenerative diseases. Circadian rhythms naturally weaken with aging, but there are particularities according to age. Throughout life, sleep and circadian rhythm disorders are strongly bidirectionally related to the pathophysiology of some psychiatric and neurodegenerative diseases, such as Alzheimer\u27s and Parkinson\u27s diseases. This knowledge could potentially create valuable opportunities to improve the health of the world\u27s population that is under circadian misalignment and aging
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