Recurrent Abdominal Actinomycosis With Multiple Organ Involvement: A Rare Clinical Presentation

Actinomycosis is a chronic granulomatous bacterial disease. It has a tendency to spread contagiously and suppurate forming granulation tissue, and multiple abscesses, which drain through skin forming sinus tracts. Sulphur granules discharging through sinus tracts are the characteristic features. Its varied presentation is always confused with malignancy rather than an infective process. We report an extraordinary case of recurrent abdominal wall actinomycosis spreading to the liver, right kidney, intestine,and pelvic organs because of discontinued treatment with penicillin. We emphasize the importance of long-term antibiotic treatment, which if deferred can lead to recurrence of the disease which could be life threatening at times

In-vitro susceptibility of multiple drug resistant Pseudomonas aeruginosa to organic acids

Objectives: Pseudomonas aeruginosa is a classic opportunistic pathogen with innate resistance to many antibiotics anddisinfectants. Resistance to antimicrobial agents makes it the most noxious organism to eliminate from infection site. Inview of its antimicrobial resistance, an attempt was made to study its susceptibility to various organic acids.Methods: Seven clinical isolates of P. aeruginosa resistant to multiple antibiotics were subjected to in vitro susceptibilityto various organic acids by broth dilution method to find out susceptibility to various organic acids.Results: The isolates of P. aeruginosa resistant to 14 antimicrobials were found susceptible to one percent oxalic acidand trichloroacetic acid, two percent lactic acid and citric acid, and three percent acetic acid. It is interesting to note thatstrains resistant to multiple antibiotics were also found susceptible to organic acids. Oxalic acid and trichloroacetic acidwere found highly effective.Conclusions: Clinical use of oxalic acid, trichloroacetic acid and lactic acid as topical agents to treat superficial pseudomonalinfections caused by difficult strains of P. aeruginosa may be recommended after confirmation of their toxicityand in vivo efficacy in animal models. J Microbiol Infect Dis 2013; 3(2): 67-70Key words: Pseudomonas aeruginosa, Multiple Antibiotic Resistance, Susceptibility to Organic Acid

Histopathological Studies on Chronic Gastritis Associated with Helicobacter pylori Infection from Rural Area of India

Background: Helicobacter pylori infection has been implicated as a major cause of chronic gastritis. It has been categorized as class 1 carcinogen. Aim and Objectives: An attempt has been made to evaluate the incidence of H. pylori in patients with chronic gastritis and to find out histopathologic indicators of presence of H. pylori in chronic gastritis. Material and Methods: A total of 101 biopsies from patients with chronic gastritis were evaluated using H & E and Giemsa stains. Biopsies were histopathologically graded according to the 1994 Updated Sydney system. Results: Neutrophilic activity was noted in 78 (77.2%), lymphoid aggregates were noted in 23 (22.7%) and atrophy was noted in 17 (16.83%) biopsies. The mononuclear cell infiltrate grading was mild in 43, moderate in 47 and marked in 11 biopsies. H. pylori were found positive in 79 (78.2%) biopsies. Neutrophilic activity with chronic gastritis and H. pylori association was highly significant (p value - -12 4.826×10 ). Significant association of presence of lymphoid aggregate with chronic gastritis and H. pylori (p value-0.0095) was also noted. Conclusion: Cases with chronic gastritis associated with neutrophilic activity with presence of lymphoid aggregate suggest H. pylori infection. Institution of rational treatment based on accurate diagnosis and eradication of H. pylori significantly reduces use of acid suppression and the risk for development of gastric malignancies