991 research outputs found
Triangle anomaly in Weyl semi-metals
Weyl semimetals possess massless chiral quasi-particles, and are thus
affected by the triangle anomalies. We discuss the features of the chiral
magnetic and chiral vortical effects specific to Weyl semimetals, and then
propose three novel phenomena caused by the triangle anomalies in this
material: 1) anomaly cooling; 2) charge transport by soliton waves as described
by the Burgers' equation, and 3) the shift of the BKT phase transition of
superfluid vortices coupled to Weyl fermions. In addition, we establish the
conditions under which the chiral magnetic current exists in real materials.Comment: v3. Improved figures, minor changes in the text, 24 pages, 3 figure
Two-Allergen Model Reveals Complex Relationship between IgE Crosslinking and Degranulation
SummaryAllergy is an immune response to complex mixtures of multiple allergens, yet current models use a single synthetic allergen. Multiple allergens were modeled using two well-defined tetravalent allergens, each specific for a distinct IgE, thus enabling a systematic approach to evaluate the effect of each allergen and percentage of allergen-specific IgE on mast cell degranulation. We found the overall degranulation response caused by two allergens is additive for low allergen concentrations or low percent specific IgE, does not change for moderate allergen concentrations with moderate to high percent specific IgE, and is reduced for high allergen concentrations with moderate to high percent specific IgE. These results provide further evidence that supraoptimal IgE crosslinking decreases the degranulation response and establishes the two-allergen model as a relevant experimental system to elucidate mast cell degranulation mechanisms
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