Synthesis of Polyamino-Carboxylate Scaffolds for Biological and Biomedical Applications

Noninvasive techniques for disease imaging and targeted therapy allow for personalized treatment regimens. Radiometal-based imaging and therapeutic agents are expanding due to the increasing availability of 64Cu, 89Zr, 55Co, and other isotopes. When coupled to an antibody or other targeting group using an appropriate bifunctional chelator, clinicians can view the localization of the radiopharmaceutical and monitor disease progression using Positron Emission Tomography. Each isotope requires a different chelator to properly bind the radiometal. When translating a compound from the benchtop to the clinic, any change in chelator requires a completely new set of tests to determine safety and efficacy. Here, we developed a panel of chelators capable of binding radiometals used in both imaging and therapeutics. These multi-use chelators pave the way for the application of a single compound for both cancer detection and targeted therapy, thereby speeding clinical development and enhancing patient outcomes

Structural effects on the magnetic hyperthermia properties of iron oxide nanoparticles

AbstractMagnetic iron oxide nanoparticles (IONPs) are heavily explored as diagnostic and therapeutic agents due to their low cost, tunable properties, and biocompatibility. In particular, upon excitation with an alternating current (AC) magnetic field, the NPs generate localized heat that can be exploited for therapeutic hyperthermia treatment of diseased cells or pathogenic microbes. In this review, we focus on how structural changes and inter-particle interactions affect the heating efficiency of iron oxide-based magnetic NPs. Moreover, we present an overview of the different approaches to evaluate the heating performance of IONPs and introduce a new theranostic modality based on magnetic imaging guided–hyperthermia