Chinese investeringen in Europa

Chinese investeringen in Europa zijn de afgelopen jaren sterk toegenomen. Relatief weinig van deze investeringen hebben echter in Nederland plaatsgevonden. Om in de toekomst nieuwe Chinese investeringen aan te trekken moet Nederland zich richten op een aantal specifieke functies en sectoren

Functional and Sectoral Division of Labour within Central and Eastern European Countries: Evidence from Greenfield FDI

__Abstract__ In this paper, we analyse the sectoral and functional division of labour in Central and Eastern European (CEE) regions within the convergence debate. By analysing the investment decisions of multinational corporations in 49 NUTS-2 regions across 6 European CEE countries (Poland, Czech Republic, Slovakia, Hungary, Romania, and Bulgaria), we show that capital city regions not only receive more greenfield FDI but also attract a larger variety of investments in terms of sectors and functions. Capital cities are more likely to host higher-end sectors and functions, which provides an explanation for the existing regional disparities within CEE countries. These results highlight the importance of functional and sectoral divisions of labour in the view of regional profiling and contribute to the recent EU Cohesion Policy debate

Modeling biogeomorphological interactions in underwater nourishments

To prevent sandy coastlines from further erosion, nourishments are executed in which sand is usually put underwater at the foreshore. Waves and currents transport the sand on the beach and in this way stabilize the coastal profile. Little is known about the interactions of these so-called shoreface nourishments with the benthic populations inhabiting the coastal strip. Benthos is affected by the nourishments, but benthic populations could in turn affect the morphological evolution of the nourished coast. Monitoring has shown that the benthic community will mainly recovery after ca. 1 year. However, the impact of benthos on the sediment dynamics and hydrodynamics is unknown. In this paper we focus on tube building worms, which have a large abundance in the foreshore, live in patches of several square meters in diameter and protrude several centimeters from the sediment in the water column. Tube building worms are included in a numerical modeling tool (Delft3D), by explicitly accounting for the influence of cylindrical structures on drag and turbulence by an extra source term of friction force in the momentum equation and an extra source term of Total Kinetic Energy (TKE) and turbulent energy dissipation in the k-ε equations respectively. The model is validated against field and flume experiments and it shows a significant influence on flow velocities near the bed, bed shear stress and bed-load transport rates. Moreover, model results reveal that tube building worms are able to stabilize nourishments and slow down the migration of the outer breaker bar. Present model explorations indicate that future research should focus on the measurement of the patchy distribution of bio-engineers in the foreshore and their impact on the sediment dynamics and hydrodynamics. Such knowledge will enable process based modeling of the spatial and temporal variation in biological activity on the morphological development of the coastal profile and also it will lead to validation of the proposed model with field measurements.</jats:p

Revealed competition between cluster organizations: An exploratory analysis of the European life sciences sector

Extant cluster policy research has largely ignored the particular role that cluster organizations play in reifying cluster policies in practice. Based on a survey of 163 cluster organizations in the European life sciences sector, this study explores the heterogeneity of cluster organizations in geographic space and examines whether and where revealed competition – defined as the combined overlap in service offerings, sub-sectoral focus and funding sources – between life science cluster organizations within European regions is most apparent. The findings indicate that the degree of functional and sectoral substitutability of cluster organizations differs substantially across Europe, though some regions, particularly in Spain, Denmark, France and Estonia, are more prone to revealed competition

Revealed competition between cluster organizations: An exploratory analysis of the European life sciences sector

Extant cluster policy research has largely ignored the particular role that cluster organizations play in reifying cluster policies in practice. Based on a survey of 163 cluster organizations in the European life sciences sector, this study explores the heterogeneity of cluster organizations in geographic space and examines whether and where revealed competition – defined as the combined overlap in service offerings, sub-sectoral focus and funding sources – between life science cluster organizations within European regions is most apparent. The findings indicate that the degree of functional and sectoral substitutability of cluster organizations differs substantially across Europe, though some regions, particularly in Spain, Denmark, France and Estonia, are more prone to revealed competition

Comparative analysis of Ig and TCR gene rearrangements at diagnosis and at elapse of childhood precursor-B–ALL provides improved strategies for selection of stable PCR targets for monitoring of minimal residual disease

Immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements are excellent patient-specific polymerase chain reaction (PCR) targets for detection of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL), but they might be unstable during the disease course. Therefore, we performed detailed molecula

Non-Surgical Respiratory Management in Relation to Feeding and Growth in Patients with Robin Sequence; a Prospective Longitudinal Study

Objective: To reflect upon our non-surgical respiratory management by evaluating clinical outcomes regarding airway, feeding, and growth during the first year of life in patients with Robin Sequence. Design: Prospective study. Setting: Sophia Children's Hospital, Rotterdam, the Netherlands. Patients/ Participants: 36 patients with Robin Sequence who were treated between 2011 and 2021. Interventions: Positional therapy and respiratory support. Main Outcome Measure(s): Data on respiratory outcomes included polysomnography characteristics and capillary blood gas values. Feeding outcomes were based on the requirement of additional tube feeding. Outcomes on growth were expressed as standard-deviation-scores (SDS) for weight-for-age (WFA) and height-for-age (HFA). Results: Twenty patients were treated with positional therapy (PT), whilst the other 16 patients required respiratory support. Twenty-two patients presented with non-isolated Robin Sequence (RS). During the first year of life, obstructive apnea hypopnea index decreased, oxygen levels enhanced, and capillary blood gas values improved. Eighty-six percent (31/36) experienced feeding difficulties, which completely resolved in 71% (22/31) during their first year of life. From start treatment, to stop treatment, to the age of 1 year, the SDS WFA worsened from −0.40 to −0.33 to −1.03, respectively. Conclusions: Non-surgical respiratory treatment resulted in an improvement of respiratory outcomes to near normal during the first year of life in patients with RS. These patients often experience feeding difficulties and endure impaired weight gain up to 1 year of age, despite near normalization of breathing. The high prevalence of feeding difficulties and impaired weight for age indicate the urgency for early recognition and adequate treatment to support optimal growth.</p

A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the mullerian duct

The activin and TGF-beta type II receptors are members of a separate subfamily of transmembrane receptors with intrinsic protein kinase activity, wh