648 research outputs found
Wave Effect Neutron Radiographic Imaging Origins in WCNR and Prospects for Low Cost Systems
AbstractThe origins of wave effect neutron test methods for advanced neutron radiography as published in World Conference on Neutron Radiography (WCNR) series has been reviewed. They include Neutron Holography demonstrated at the Dido reactor, Harwell, UK; Neutron Refraction and Small Angle Scattering demonstrated at the IR-8 reactor, Kurchatov Institute, Moscow, Russia; and Neutron Interferometry demonstrated at the ILL reactor, Grenoble, France. Each case presents encouraging evidence that the advanced techniques currently practiced at the most advanced shared-user facilities could be built upon at some lower cost, single-user facilities if the lessons of the original low cost experiments are studied
Health-related quality of life before and after management in adults referred to otolaryngology: rospective national study
Objective: An assessment of the effect of otolaryngological management on the health-related quality of life of patients.
Design: Application of the Health Utilities Index mark 3 (HUI-3) before and after treatment; application of the Glasgow Benefit Inventory (GBI) after treatment.
Setting: Six otolaryngological departments around Scotland.
Participants: A 9005 adult patients referred to outpatient clinics.
Main outcome measures: Complete HUI-3 data was collected from 4422 patients; complete GBI data from 4235; complete HUI-3 and GBI data from 3884.
Results: The overall change in health related quality of life from before to after management was just +0.02. In the majority of subgroups of data (classified by type of management) there was essentially no change in HUI-3 score. The major exceptions were those patients provided with a hearing aid (mean change 0.08) and those whose problem was managed surgically (mean change 0.04). The mean GBI score was 5.3 which is low. Those managed surgically reported a higher GBI score of 13.0.
Conclusion: We found that patients treated surgically or given a hearing aid reported a significant improvement in their health related quality of life after treatment in otolaryngology departments. In general, patients treated in other ways reported no significant improvement. We argue that future research should look carefully at patient groups where there is unexpectedly little benefit from current treatment methods and consider more effective methods of management
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Multi-purpose neutron radiography system
A conceptual design is given for a low cost, multipurpose radiography system suited for the needs of the Los Alamos National Laboratory (LANL). The proposed neutron source is californium-252. One purpose is to provide an in-house capability for occasional, reactor quality, neutron radiography thus replacing the recently closed Omega-West Reactor. A second purpose is to provide a highly reliable standby transportable neutron radiography system. A third purpose is to provide for transportable neutron probe gamma spectroscopy techniques. The cost is minimized by shared use of an existing x-ray facility, and by use of an existing transport cask. The achievable neutron radiography and radioscopy performance characteristics have been verified. The demonstrated image qualities range from high resolution gadolinium - SR film, with L:D = 100:1, to radioscopy using a LIXI image with L:D = 30:1 and neutron fluence 3.4 x 10{sup 5} n/cm{sup 2}
Nonlinear Phase Separation Testing of an Experimental Wing-Engine Structure
Modal testing of nonlinear engineering structures is currently a research area that attracts substantial attention. Recently, a nonlinear generalisation of phase separation testing has been proposed for identifying nonlinear normal modes (NNMs) based on input and output measurements. The nonlinear phase separation (NPS) method integrates identification and continuation tools to calculate multiple NNMs from broadband data. The present contribution reports the first experimental application of the NPS method. The structure of interest is a model inspired by a wing with two engines connected by means of nonlinear pylons with softening-hardening stiffness characteristics. The frequency-energy dependences of four NNMs in the 0-100 Hz range are estimated, including modal interactions. NNMs identified using the NPS method are also compared to free-decay testing results
Coupled Dipole Method Determination of the Electromagnetic Force on a Particle over a Flat Dielectric Substrate
We present a theory to compute the force due to light upon a particle on a
dielectric plane by the Coupled Dipole Method (CDM). We show that, with this
procedure, two equivalent ways of analysis are possible, both based on
Maxwell's stress tensor. The interest in using this method is that the nature
and size or shape of the object, can be arbitrary. Even more, the presence of a
substrate can be incorporated. To validate our theory, we present an analytical
expression of the force due to the light acting on a particle either in
presence, or not, of a surface. The plane wave illuminating the sphere can be
either propagating or evanescent. Both two and three dimensional calculations
are studied.Comment: 10 pages, 8 figures and 3 table
Identification of dermatophytes by sequence analysis of the rRNA gene internal transcribed spacer regions
Identification of dermatophytes using the traditional method is sometimes problematic because of atypical microscopic or macroscopic morphology. The aim of this study was to evaluate the feasibility of using sequencing of the ribosomal internal transcribed spacer (ITS)1 and ITS2 regions for identification of 17 dermatophyte species. The ITS regions of 188 strains (62 reference strains and 126 clinical isolates) were amplified by PCR and sequenced. Species identification was made by sequence comparison with an in-house database comprising ITS sequences of type or neotype strains or by blast searches for homologous sequences in public databases. Strains producing discrepant results between conventional methods and ITS sequence analysis were analysed further by sequencing the D1–D2 domain of the large-subunit rRNA gene for species clarification. The identification rates by ITS1 and ITS2 sequencing were higher than 97 %. Based on reference sequences of type or neotype strains, it was noted that most strains of Trichophyton mentagrophytes were misidentifications of Trichophyton interdigitale. In addition, barcode sequences were present in species of the Microsporum canis complex and Trichophyton rubrum complex. These barcode sequences are useful for species delineation when the results of ITS sequencing are ambiguous. In conclusion, ITS sequencing provides a very accurate and useful method for the identification of dermatophytes
Sample-size dependence of the ground-state energy in a one-dimensional localization problem
We study the sample-size dependence of the ground-state energy in a
one-dimensional localization problem, based on a supersymmetric quantum
mechanical Hamiltonian with random Gaussian potential. We determine, in the
form of bounds, the precise form of this dependence and show that the
disorder-average ground-state energy decreases with an increase of the size
of the sample as a stretched-exponential function, , where the
characteristic exponent depends merely on the nature of correlations in the
random potential. In the particular case where the potential is distributed as
a Gaussian white noise we prove that . We also predict the value of
in the general case of Gaussian random potentials with correlations.Comment: 30 pages and 4 figures (not included). The figures are available upon
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Envisioning shared decision making: a reflection for the next decade
Despite the evolving evidence in favor of shared decision making (SDM) and of decades-long calls for its adoption, SDM remains uncommon in routine care. Reflecting on this lack of progress, we sought to reimagine the future of SDM and the path to take us there. In late 2017, a multidisciplinary and international group of six researchers were challenged by a senior SDM scholar to envision the future and, based on a provocatively critical view of the present, to write letters to themselves from the year 2028. Letters were exchanged and discussed electronically. The group then met in person to discuss the letters. Since the letters painted a dystopian picture, they triggered questions about the nature of SDM, who should benefit from SDM, how to measure its contribution to care, and what new ways can be invented to design and test interventions to implement SDM in routine care. Through contrasting the purposefully generated dystopias with an ideal future for SDM, we generated reflections on a research agenda for SDM. These reflections hinged on recognizing SDM's contributing to care, that is, as a way to advance the problematic human situation of patients. These focused on three distinct yet complimentary contributors to SDM: 1) the process of making decisions, 2) humanistic communication, and 3) fit-to-care of the resulting decision. The group then concluded that to move SDM from envisioned to routine practice, and to ensure it reaches all, particularly persons rendered vulnerable by current forms of health care, a substantial investment in implementation research is necessary. Perhaps the discussion of these reflections can contribute to a path forward that will improve the likelihood of the future we dream for SDM.Analysis and support of clinical decision makin
Decoupling in an expanding universe: boundary RG-flow affects initial conditions for inflation
We study decoupling in FRW spacetimes, emphasizing a Lagrangian description
throughout. To account for the vacuum choice ambiguity in cosmological
settings, we introduce an arbitrary boundary action representing the initial
conditions. RG flow in these spacetimes naturally affects the boundary
interactions. As a consequence the boundary conditions are sensitive to
high-energy physics through irrelevant terms in the boundary action. Using
scalar field theory as an example, we derive the leading dimension four
irrelevant boundary operators. We discuss how the known vacuum choices, e.g.
the Bunch-Davies vacuum, appear in the Lagrangian description and square with
decoupling. For all choices of boundary conditions encoded by relevant boundary
operators, of which the known ones are a subset, backreaction is under control.
All, moreover, will generically feel the influence of high-energy physics
through irrelevant (dimension four) boundary corrections. Having established a
coherent effective field theory framework including the vacuum choice
ambiguity, we derive an explicit expression for the power spectrum of
inflationary density perturbations including the leading high energy
corrections. In accordance with the dimensionality of the leading irrelevant
operators, the effect of high energy physics is linearly proportional to the
Hubble radius H and the scale of new physics L= 1/M.Comment: LaTeX plus axodraw figures. v2: minor corrections; refs added. JHEP
style: 34 pages + 18 pages appendi
Atomic layering at the liquid silicon surface: a first- principles simulation
We simulate the liquid silicon surface with first-principles molecular
dynamics in a slab geometry. We find that the atom-density profile presents a
pronounced layering, similar to those observed in low-temperature liquid metals
like Ga and Hg. The depth-dependent pair correlation function shows that the
effect originates from directional bonding of Si atoms at the surface, and
propagates into the bulk. The layering has no major effects in the electronic
and dynamical properties of the system, that are very similar to those of bulk
liquid Si. To our knowledge, this is the first study of a liquid surface by
first-principles molecular dynamics.Comment: 4 pages, 4 figures, submitted to PR
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