Culture and the state Institutionalizing ‘the underclass’ in the new Ireland

This paper analyses some of the activities of a community development group connected to a very poor neighbourhood in Dublin, Ireland within the context of anti-poverty discourses and types of targeted funding generated by the European Union. Community development groups and discourses are saturated with terms such as the ‘social market’, ‘inclusion’ and ‘community’ that are an interesting combination of progressive politics and concepts recognizably connected to social science disciplines like Anthropology and Human Geography. In this essay, the authors examine a ‘community’ response to the so-called ‘horse protest’ in Dublin, a response in large part funded by EU mechanisms geared to combating ‘social exclusion’. They also trace back some of the connections between the institutional actors in this community and EU policies and funding mechanisms. Finally, they examine the trajectory of the Republic of Ireland, especially its experience of a booming economy, that has influenced perceptions of, and reactions to, problems in this neighbourhood. This work represents an attempt to merge ethnographic data and policy analysis within one textual frame, and in particular it represents the authors’ attempt to understand how certain discursive sign-posts like ‘social exclusion’ are given content as concrete social-historical processes

Coexisting depressive symptoms do not limit the benefits of chronic neuromodulation: A study of over 200 patients

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142918/1/nau23356_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142918/2/nau23356.pd

Difficult Life Events, Selective Migration and Spatial Inequalities in Mental Health in the UK

Objective: Research has indicated that people moving towards neighbourhoods with disadvantaged socio-economic status have poor health, in particular mental health, but the reasons for this are unclear. This study aims to assess why people moving towards more socio-economically deprived areas have poor mental health. It focuses upon the role of difficult life events that may both trigger moves and damage mental health. This study investigates how mental health and socio-spatial patterns of mobility vary between people moving following difficult life events and for other reasons.<p></p> Methods: Longitudinal analysis of British Household Panel Survey data describing adults’ moves between annual survey waves, pooled over ten years, 1996-2006 (N=122,892 observations). Respondents were defined as ‘difficult life event movers’ if they had experienced relationship breakdown, housing eviction/repossession, or job loss between waves. Respondents were categorised as moving to more or less deprived quintiles using their Census Area Statistic residential ward Carstairs score. Mental health was indicated by self-reported mental health problems. Binary logistic regression models of weighted data were adjusted for age, sex, education and social class.<p></p> Results: The migration rate over one year was 8.5%; 14.1% of movers had experienced a difficult life event during this time period. Adjusted regression model odds of mental health problems among difficult life event movers were 1.67 (95% CI 1.35-2.07) relative to other movers. Odds of difficult life events movers, compared to other movers, moving to a less deprived area, relative to an area with a similar level of deprivation, were 0.70 (95% CI 0.58-0.84). Odds of mental health problems among difficult life event movers relocating to more deprived areas were highly elevated at 2.40 (95% CI 1.63-3.53), relative to stayers.<p></p> Conclusion: Difficult life events may influence health selective patterns of migration and socio-spatial trajectories, reducing moves to less deprived neighbourhoods among people with mental illness

Vision, challenges and opportunities for a Plant Cell Atlas

With growing populations and pressing environmental problems, future economies will be increasingly plant-based. Now is the time to reimagine plant science as a critical component of fundamental science, agriculture, environmental stewardship, energy, technology and healthcare. This effort requires a conceptual and technological framework to identify and map all cell types, and to comprehensively annotate the localization and organization of molecules at cellular and tissue levels. This framework, called the Plant Cell Atlas (PCA), will be critical for understanding and engineering plant development, physiology and environmental responses. A workshop was convened to discuss the purpose and utility of such an initiative, resulting in a roadmap that acknowledges the current knowledge gaps and technical challenges, and underscores how the PCA initiative can help to overcome them.</jats:p

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Draft final report for strands I and II of social exclusion and local responses: life-histories of drugs users and drugs in the community.

In this report, we synthesize some statistical trends, ethnographic insights, and, frankly, some impressions based on long-term contact with a variety of people either directly or tangentially involved in the use and abuse of illegal drugs in the Ballyfermot, Cherry Orchard area. There are three broad sorts of data in this report. First, we have brought together the available statistics on drug use (a surprisingly difficult task) as well as the data on population trends in the Cherry Orchard and Ballyfermot area. We have also analysed the notes we have collected as part of the broader community study that were pertinent to the issues or drug use and abuse. These notes are from a multi-site study half of which was situated in Gallanstown, Cherry Orchard. As part of this data set, we collected 10 life histories from 8 men (5 Cherry Orchard and 3 Ballyfermot) and two woman (both Cherry Orchard) who have been serious drug users, according to meaningful local definitions (i.e., having regularly ingested heroin at some point in their lives with anything from bad to disastrous consequences for themselves and their loved ones). This data was supplemented with regular focus groups and informal discussions with several other addicts (5 men and 3 women), as well as a few meetings with a group of underage addicts on methadone maintenance at Fortune House in Cherry Orchard Hospital (2 boys and 3 girls). We also spoke in a less detailed, but still enlightening, way with several family members of individuals with drug problems in both Cherry Orchard and Ballyfermot

Culture and the state Institutionalizing ‘the underclass’ in the new Ireland

This paper analyses some of the activities of a community development group connected to a very poor neighbourhood in Dublin, Ireland within the context of anti-poverty discourses and types of targeted funding generated by the European Union. Community development groups and discourses are saturated with terms such as the ‘social market’, ‘inclusion’ and ‘community’ that are an interesting combination of progressive politics and concepts recognizably connected to social science disciplines like Anthropology and Human Geography. In this essay, the authors examine a ‘community’ response to the so-called ‘horse protest’ in Dublin, a response in large part funded by EU mechanisms geared to combating ‘social exclusion’. They also trace back some of the connections between the institutional actors in this community and EU policies and funding mechanisms. Finally, they examine the trajectory of the Republic of Ireland, especially its experience of a booming economy, that has influenced perceptions of, and reactions to, problems in this neighbourhood. This work represents an attempt to merge ethnographic data and policy analysis within one textual frame, and in particular it represents the authors’ attempt to understand how certain discursive sign-posts like ‘social exclusion’ are given content as concrete social-historical processes

Culture and the state Institutionalizing ‘the underclass’ in the new Ireland

This paper analyses some of the activities of a community development group connected to a very poor neighbourhood in Dublin, Ireland within the context of anti-poverty discourses and types of targeted funding generated by the European Union. Community development groups and discourses are saturated with terms such as the ‘social market’, ‘inclusion’ and ‘community’ that are an interesting combination of progressive politics and concepts recognizably connected to social science disciplines like Anthropology and Human Geography. In this essay, the authors examine a ‘community’ response to the so-called ‘horse protest’ in Dublin, a response in large part funded by EU mechanisms geared to combating ‘social exclusion’. They also trace back some of the connections between the institutional actors in this community and EU policies and funding mechanisms. Finally, they examine the trajectory of the Republic of Ireland, especially its experience of a booming economy, that has influenced perceptions of, and reactions to, problems in this neighbourhood. This work represents an attempt to merge ethnographic data and policy analysis within one textual frame, and in particular it represents the authors’ attempt to understand how certain discursive sign-posts like ‘social exclusion’ are given content as concrete social-historical processes

Culture and the state Institutionalizing ‘the underclass’ in the new Ireland

This paper analyses some of the activities of a community development group connected to a very poor neighbourhood in Dublin, Ireland within the context of anti-poverty discourses and types of targeted funding generated by the European Union. Community development groups and discourses are saturated with terms such as the ‘social market’, ‘inclusion’ and ‘community’ that are an interesting combination of progressive politics and concepts recognizably connected to social science disciplines like Anthropology and Human Geography. In this essay, the authors examine a ‘community’ response to the so-called ‘horse protest’ in Dublin, a response in large part funded by EU mechanisms geared to combating ‘social exclusion’. They also trace back some of the connections between the institutional actors in this community and EU policies and funding mechanisms. Finally, they examine the trajectory of the Republic of Ireland, especially its experience of a booming economy, that has influenced perceptions of, and reactions to, problems in this neighbourhood. This work represents an attempt to merge ethnographic data and policy analysis within one textual frame, and in particular it represents the authors’ attempt to understand how certain discursive sign-posts like ‘social exclusion’ are given content as concrete social-historical processes