36.我々の軟部悪性腫瘍の治療法(第654回千葉医学会整形外科例会)

Recording synchronous data from EEG and eye-tracking provides a unique methodological approach for measuring the sensory and cognitive processes of overt visual search. Using this approach we obtained fixation related potentials (FRPs) during a guided visual search task specifically focusing on the lambda and P3 components. An outstanding question is whether the lambda and P3 FRP components are influenced by concurrent task demands. We addressed this question by obtaining simultaneous eye-movement and electroencephalographic (EEG) measures during a guided visual search task while parametrically modulating working memory load using an auditory N-back task. Participants performed the guided search task alone, while ignoring binaurally presented digits, or while using the auditory information in a 0, 1, or 2-back task. The results showed increased reaction time and decreased accuracy in both the visual search and N-back tasks as a function of auditory load. Moreover, high auditory task demands increased the P3 but not the lambda latency while the amplitude of both lambda and P3 was reduced during high auditory task demands. The results show that both early and late stages of visual processing indexed by FRPs are significantly affected by concurrent task demands imposed by auditory working memory

Light baryon magnetic moments and N -> Delta gamma transition in a Lorentz covariant chiral quark approach

We calculate magnetic moments of light baryons and N -> Delta gamma transition characteristics using a manifestly Lorentz covariant chiral quark approach for the study of baryons as bound states of constituent quarks dressed by a cloud of pseudoscalar mesons.Comment: 29 pages, 10 figures, accepted for publication in Phys. Rev.

Nucleon Structure and Parity-Violating Electron Scattering

We review the area of strange quark contributions to nucleon structure. In particular, we focus on current models of strange quark vector currents in the nucleon and the associated parity-violating elastic electron scattering experiments from which vector- and axial-vector currents are extractedComment: 40 pages including 7 figures; review article to be published in Int. J. Mod. Phys.

The Causes of Foehn Warming in the Lee of Mountains

The foehn effect is well known as the warming, drying, and cloud clearance experienced on the lee side of mountain ranges during “flow over” conditions. Foehn flows were first described more than a century ago when two mechanisms for this warming effect were postulated: an isentropic drawdown mechanism, where potentially warmer air from aloft is brought down adiabatically, and a latent heating and precipitation mechanism, where air cools less on ascent—owing to condensation and latent heat release—than on its dry descent on the lee side. Here, for the first time, the direct quantitative contribution of these and other foehn warming mechanisms is shown. The results suggest a new paradigm is required after it is demonstrated that a third mechanism, mechanical mixing of the foehn flow by turbulence, is significant. In fact, depending on the flow dynamics, any of the three warming mechanisms can dominate. A novel Lagrangian heat budget model, back trajectories, high-resolution numerical model output, and aircraft observations are all employed. The study focuses on a unique natural laboratory—one that allows unambiguous quantification of the leeside warming—namely, the Antarctic Peninsula and Larsen C Ice Shelf. The demonstration that three foehn warming mechanisms are important has ramifications for weather forecasting in mountainous areas and associated hazards such as ice shelf melt and wildfires

α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in

Damage-associated molecular patterns (DAMPs) are molecules exposed or released by dead cells that trigger or modulate immunity and tissue repair. In vertebrates, the cytoskeletal component F-actin is a DAMP specifically recognised by DNGR-1, an innate immune receptor. Previously we suggested that actin is also a DAMP in Drosophila melanogaster by inducing STATdependent genes (Srinivasan et al., 2016). Here, we revise that conclusion and report that aactinin is far more potent than actin at inducing the same STAT response and can be found in trace amounts in actin preparations. Recombinant expression of actin or a-actinin in bacteria demonstrated that only a-actinin could drive the expression of STAT target genes in Drosophila. The response to injected a-actinin required the same signalling cascade that we had identified in our previous work using actin preparations. Taken together, these data indicate that a-actinin rather than actin drives STAT activation when injected into Drosophila

New Frontiers-class Uranus Orbiter: Exploring the feasibility of achieving multidisciplinary science with a mid-scale mission

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The case for a New Frontiers-class Uranus Orbiter:System science at an underexplored and unique world with a mid-scale mission

Current knowledge of the Uranian system is limited to observations from the flyby of Voyager 2 and limited remote observations. However, Uranus remains a highly compelling scientific target due to the unique properties of many aspects of the planet itself and its system. Future exploration of Uranus must focus on cross-disciplinary science that spans the range of research areas from the planet's interior, atmosphere, and magnetosphere to the its rings and satellites, as well as the interactions between them. Detailed study of Uranus by an orbiter is crucial not only for valuable insights into the formation and evolution of our solar system but also for providing ground truths for the understanding of exoplanets. As such, exploration of Uranus will not only enhance our understanding of the ice giant planets themselves but also extend to planetary dynamics throughout our solar system and beyond. The timeliness of exploring Uranus is great, as the community hopes to return in time to image unseen portions of the satellites and magnetospheric configurations. This urgency motivates evaluation of what science can be achieved with a lower-cost, potentially faster-turnaround mission, such as a New Frontiers–class orbiter mission. This paper outlines the scientific case for and the technological and design considerations that must be addressed by future studies to enable a New Frontiers–class Uranus orbiter with balanced cross-disciplinary science objectives. In particular, studies that trade scientific scope and instrumentation and operational capabilities against simpler and cheaper options must be fundamental to the mission formulation