660 research outputs found
Ex-ante assessment of demand for improved forage seed and planting materials among Ethiopian smallholder farmers: A contingent valuation analysis
United States Agency for International Developmen
Ex-ante assessment of demand for improved forage seed and planting materials among smallholder farmers in Ethiopia: A contingent valuation analysis
United States Agency for International Developmen
Ex-ante assessment of potential market demands and commercial viabilities for private forage seeds production in Ethiopia
United States Agency for International Developmen
Value chains, markets and economics: Africa RISING Science, Innovations and Technologies with Scaling Potential from the Ethiopian Highlands
United States Agency for International Developmen
Uniform cross phase modulation for nonclassical radiation pulses
We propose a scheme to achieve a uniform cross phase modulation (XPM) for two
nonclassical light pulses and study its application for quantum non-demolition
measurements of the photon number in a pulse and for controlled phase gates in
quantum information. We analyze the scheme by quantizing a common
phenomenological model for classical XPM. Our analysis first treats the ideal
case of equal cross-phase modulation and pure unitary dynamics. This
establishes the groundwork for more complicated studies of non-unitary dynamics
and difference in phase shifts between the two pulses where decohering effects
severely affect the performance of the scheme.Comment: 11 pages, 4 figures. To appear in J. Opt. Soc. Am.
Integrated bio-economic simulation model for traditional cattle production systems in Ethiopia: Ex-ante evaluation of policies and investments
Transforming traditional smallholder cow milk production systems in Ethiopia: Ex-ante evaluation
Integrated bio-economic simulation model for goat production: Ex-ante evaluation of investment opportunities in Ethiopia
Integrated bio-economic simulation model for sheep production: Ex-ante evaluation of investment opportunities in Ethiopia
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients
The tumor suppressors Tsc1 and Tsc2 form the tuberous sclerosis complex (TSC), a regulator of mTOR activity. Tsc1 stabilizes Tsc2; however, the precise mechanism involved remains elusive. The molecular chaperone heat-shock protein 90 (Hsp90) is an essen- tial component of the cellular homeostatic machinery in eukary- otes. Here, we show that Tsc1 is a new co-chaperone for Hsp90 that inhibits its ATPase activity. The C-terminal domain of Tsc1 (998–1,164 aa) forms a homodimer and binds to both protomers of the Hsp90 middle domain. This ensures inhibition of both subunits of the Hsp90 dimer and prevents the activating co- chaperone Aha1 from binding the middle domain of Hsp90. Conversely, phosphorylation of Aha1-Y223 increases its affinity for Hsp90 and displaces Tsc1, thereby providing a mechanism for equilibrium between binding of these two co-chaperones to Hsp90. Our findings establish an active role for Tsc1 as a facilita- tor of Hsp90-mediated folding of kinase and non-kinase clients— including Tsc2—thereby preventing their ubiquitination and proteasomal degradation
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