5 research outputs found
Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years
- Author
- Adarraga Ma Dolores
- Adela Rodriguez-Hernandez A
- Aibar Jesus
- Alejandro Lorente Manuel
- Alfonso Maria
- Amado Cristina
- Angel Aibar Miguel
- Angeles Rodriguez-Davila Ma
- Angelina Garcia Maria
- Antonio Diaz-Peromingo Jose
- Antonio Nieto Jose
- Antonio Porras Jose
- Ballaz Aitor
- Barba Raquel
- Barillari Giovanni
- Barron Manuel
- Barron-Andres Belen
- Bascunana Jose
- Benzidia Ilham
- Bertoletti Laurent
- Bilora Franca
- Blanco-Molina Angeles
- Bortoluzzi Cristiano
- Bosco Lopez-Saez Juan
- Bosevski Marijan
- Bounameaux Henri
- Braester Andrei
- Brandolin Barbara
- Brenner Benjamin
- Bucherini Eugenio
- Bura-Riviere Alessandra
- Canas Inmaculada
- Caprini Joseph A
- Carles Sahuquillo Joan
- Carmen Olivares Maria
- Carrasco Cristina
- Castro Joaquin
- Celis Gregory
- Ciammaichella Maurizio
- de Ancos Cristina
- Debourdeau Philippe
- Del Carmen Fernandez-Criado Maria
- del Carmen Gayol Maria
- del Pozo Gustavo
- Del Toro Jorge
- del Valle Morales Ma
- Demelo Pablo
- Dentali Francesco
- Di Micco Pierpaolo
- Diaz-Simon Raquel
- Dolores Joya Maria
- Falga Conxita
- Farge-Bancel Dominique
- Fernandez-Capitan Carmen
- Fernandez-Nunez Sandra
- Fidalgo Angeles
- Font Carme
- Font Llorenc
- Garcia-Bragado Fernando
- Garcia-Morillo Marcial
- Garcia-Raso Aranzzu
- Gavin-Sebastian Olga
- Gibietis Valdis
- Gil-Diaz Aida
- Gomez Vicente
- Gomez-Cuervo Covadonga
- Gonzalez-Martinez Jose
- Grau Enric
- Gutierrez Javier
- Gutierrez Paula
- Gutierrez-Gonzalez Sara
- Hanh My Bui
- Hernandez Blasco Luis
- Hij Adrian
- Hirmerova Jana
- Hong Ngoc Vo
- Iglesias Marina
- Ignacio Arcelus Juan
- Isabel Farfan Ana
- Isabel Torres Maria
- Jara-Palomares Luis
- Jaras Ma Jesus
- Javier Marchena Pablo
- Javier Vazquez Fernando
- Jesus Nunez Manuel
- Jimenez David
- Jose Lopez-Nunez Juan
- Jou Ines
- Khanh Quoc Pham
- Kigitovica Dana
- Lalueza Antonio
- Lima Jorge
- Llamas Pilar
- Lopez Reyes Raquel
- Lopez-Jimenez Luciano
- Lopez-Miguel Patricia
- Lorenzo Alicia
- Loring Monica
- Luis Lobo Jose
- Luisa Nieto Maria
- Madridano Olga
- Maestre Ana
- Mahe Isabelle
- Maida Rosa
- Maly Radovan
- Maria Camon Ana
- Maria Pedrajas Jose
- Maria Surinach Jose
- Mastroiacovo Daniela
- Mazzolai Lucia
- Mellado Meritxell
- Miguel Martin Javier
- Monreal Manuel
- Moustafa Fares
- Mumoli Nicola
- Otero Remedios
- Pace Federica
- Parisi Roberto
- Pellejero Galadriel
- Peris Ma Luisa
- Pesavento Raffaelle
- Prandoni Paolo
- Prez-Rus Gloria
- Quintavalla Roberto
- Reis Abilio
- Rivas Agustina
- Rocci Anna
- Romualdi Roberta
- Rubio Carmen Ma
- Ruiz-Artacho Pedro
- Ruiz-Ruiz Justo
- Ruiz-Sada Pablo
- Salazar Vladimir
- Salgado Estuardo
- Samperiz Angel
- Sanchez Munoz-Torrero Juan Francisco
- Sancho Teresa
- Schellong Sebastian
- Sharif-Kashani Babak
- Sinicalchi Carmine
- Skride Andris
- Soler Silvia
- Tapia Elena
- Tolosa Caries
- Trujillo-Santos Javier
- Tufano Antonella
- Tzoran Inna
- Uresandi Fernando
- Valle Reina
- Vanassche Thomas
- Vandenbriele Christophe
- Verhamme Peter
- Vidal Gemma
- Vilaseca Alicia
- Villares Paula
- Visona Adriana
- Zalunardo Beniamino
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
publishersversionPeer reviewe
Prediction of early mortality in patients with cancer-associated thrombosis in the RIETE Database
- Author
- Adarraga Maria D.
- Aibar Jesus
- Aibar Miguel A.
- Alatri Adriano
- Amado Cristina
- Angeles Fidalgo Maria
- Aranda Carlos
- Arcelus Juan
- Ballaz Aitor
- Barba Raquel
- Barillari Giovanni
- Barron Manuel
- Barron-Andres Belen
- Bascunana Jose
- Benzidia Ilham
- Bertoletti Laurent
- Bilora Franca
- Blanco-Molina Angeles
- Bortoluzzi Cristiano
- Bosevski Marijan
- Bounameaux Henri
- Braester Andrei
- Brandolin Barbara
- Brenner Benjamin
- Bucherini Eugenio
- Bura-Riviere Alessandra
- Camon Ana M.
- Caprini Joseph A.
- Carrasco Cristina
- Castro Joaquin
- Cesta Alisia
- Ciammaichella Maurizio
- Cruz Javier A.
- de Ancos Cristina
- del Carmen Diaz-pedroche Maria
- del Carmen Olivares Maria
- del Toro Jorge
- del Valle Morales Maria
- Demelo Pablo
- Dentali Francesco
- Di Micco Pierpaolo
- Di Pangrazio Marco
- Diaz-Peromingo Jose A.
- Ellis Martin
- Encabo Marta
- Falga Conxita
- Falvo Nicolas
- Farfan Ana
- Farge-bancel Dominique
- Fernandez-Capitan Carmen
- Font Carme
- Font Llorenc
- Fresa Marco
- Fuentes Harry E.
- Furest Ildefonso
- Garcia Maria A.
- Garcia-Braoado Ferran
- Garcia-Morillo Marcia
- Garcia-Raso Aranzazu
- Gavin Olga
- Gil-Diaz Aida
- Gomez Vicente
- Gomez-Cuervo Covadonga
- Gonzalez-Martinez Jose
- Grandone Elvira
- Grau Enric
- Guijarro Ricardo
- Gutierrez Javier
- Gutierrez Paula
- Hanh My Bui
- Hernandez-Blasco Luis
- Hirmerova Jana
- Hu Adrian
- I
- I
- I
- Imbalzano Egidio
- Jara-Palomares Luis
- Jaras Maria J.
- Jimenez David
- Jou Ines
- Joya Maria D.
- Krstevski Gorjan
- Lessiani Gianfranco
- Lima Jorge
- Llamas Pilar
- Lobo Jose L.
- Lopez-Jimenez Luciano
- Lopez-Miguel Patricia
- Lopez-Nunez Juan J.
- Lopez-Reyes Raquel
- Lopez-Saez Juan B.
- Lorente Manuel A.
- Lorenzo Alicia
- Loring Monica
- Lumbierres Marina
- Mahe Isabelle
- Maida Rosa
- Maly Radovan
- Manrique-Abos Isabel
- Marchena Pablo J.
- Martin-Fernandez Miguel
- Martin-Guerra Javier M.
- Martin-Romero Miguel
- Mastroiacovo Danicla
- Mazzolai Lucia
- Mellado Meritxell
- Merah Adel
- Monreal Manuel
- Moustafa Fares
- Ney Barbara
- Ngoc Vo Hong
- Nieto Jose A.
- Nunez Manuel J.
- Otalora Sonia
- Otero Remedios
- Pace Federica
- Parisi Roberto
- Pedrajas Jose Maria
- Pellejero Galadriel
- Perez-Ductor Cristina
- Perez-Jacoiste Asuncion
- Perez-Rus Gloria
- Peris Maria L.
- Pesavento Raffaele
- Pesce Maria L.
- Porras Jose A.
- Prandoni Paolo
- Quinta-Valla Roberto
- Riesco David
- Rivas Agustina
- Rocci Anna
- Rodriguez-Davila Maria A.
- Rodriguez-Hernandez Adela
- Rosa Vladimir
- Rubio Carmen M.
- Ruiz-Alcaraz Sandra
- Ruiz-Artacho Pedro
- Ruiz-Ruiz Justo
- Ruiz-Sada Pablo
- Ruiz-Torregrosa Paloma
- Sahuquillo Joan C.
- Sala-Sainz Carmen
- Salgado Estuardo
- Samperiz Angel
- Sanchez-Munoz-Torrero Juan F.
- Sancho Teresa
- Sanoja Indra D.
- Siniscalchi Carmine
- Skride Andris
- Soler Silvia
- Sotgiu Pietro
- Soto Maria J.
- Surinach Jose M.
- Tafur Alfonso J.
- Tiraferri Eros
- Tonello Diego
- Torres Maria
- Trujillo-santos Javier
- Tufano Antonella
- Tzoran Inns
- Uresandi Fernando
- Usandizaga Esther
- Valle Reins
- Vanassche Thomas
- Vandenbriele Christophe
- Vazquez Fernando J.
- Verhamme Peter
- Vilaseca Alicia
- Villalobos Aurora
- Visona Adriana
- Yoo Hugo H.
- Zdraveska Marija
- Publication venue
- 'Edizioni Minerva Medica'
- Publication date
- 01/01/2019
- Field of study
Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy
- Author
- Aiello Joseph
- Alamartine Eric
- Alejandra
- Alexander Rovin
- Altiparmak Mehmet Riza
- Alvarez Magdalena
- Andrew Cattran
- Arriola Mariano
- Ayoub Isabelle
- Baker Richard
- Barbour Sean
- Barratt
- Barron Maria Belen
- Boletis Ioannis
- Bovy Christophe
- Brad H. Fragale
- Budde Klemens
- Campbell Kirk
- Canetta Pietro
- Cartery Claire
- Cassini Evelin
- Chen Cheng-Hsu
- Chen Lianhua
- Chen Menghua
- Chen Qinkai
- Cheng Hong
- Cheung Chee Kay
- Chiurchiu Carlos
- Coppock Gaia
- Cournoyer Serge
- Cozzolino Mario Gennaro
- Daniel Floege
- Daroux Maite
- De La Fuente Jorge
- Demoulin Nathalie
- Dionisi Maria Paula
- Duman Soner
- Ergul Metin
- Esposito Ciro
- Fedosiuk Elena
- Fellstrom Bengt
- Fischbach Bernard
- Francis Ross
- Fu Ping
- Garcia Eva Rodriguez
- Gesualdo Loreto
- Giotto Ana
- Goicoechea Marian
- Goumenos Dimitrios
- Guillermo Karl
- Guron Gregor
- Hall Matthew
- Hemmingsson Peter
- HernĂĄn Zhang
- Hladunewich Michelle
- Hong Eren
- Hougardy Jean-Michel
- Hoyos Ivan Gonzalez
- Hruby Miroslav
- Hugo Christian
- Jens Stone
- John Avasare
- Jonathan Lafayette
- JĂŒrgen Tesar
- Kamal Fahmeedah
- Kanigicherla Durga
- Khwaja Arif
- Kim Dong Ki
- Kim Su-Hyun
- Kim Sung Gyun
- Kim Yong-Lim
- Kurnatowska Ilona
- Lampo Mauro Guillermo
- Laurin Louis-Philippe
- Levidiotis Vicki
- Li Shaomei
- Linfert Douglas
- Liu Bicheng
- Liu Zhangsuo
- Losisolo Patricia
- Lu Wanhong
- Luciano
- Lundberg Sigrid
- Luo Qun
- Luxton Grant
- Lv Jicheng
- Maes Bart
- Maixnerova Dita
- Makela Satu
- Maldonado Rafael
- Mark Patrick
- Masse Melanie
- Maxwell Peter
- McCafferty Kieran
- Mikhailova Elena
- Mohamed Amr
- Monkowski Matias
- Moriarty Jim
- Mottl Amy
- Mulhern Jeffrey
- Na Ki-Ryang
- Necmi Paliege
- Ni Zhaohui
- Nitschke Martin
- Novoa Pablo Antonio
- Nowicki Michal
- Ntounousi Evangelia
- Orias Marcelo
- Ortiz Fernanda
- Otte Britta
- Pai Pearl
- Pamplona Irene Agraz
- Papagianni Aikaterini
- Peh Chen Au
- Phoon Richard
- Porras Luis Quintana
- Power Albert
- Randy Sedor
- Rehorova Jitka
- Reich Heather
- Richard Kristensen
- Rizk Dana
- Robinson Derrick
- Rupali Lau
- Ryan Jessica
- Rychlik Ivan
- Sachmechi Isaac
- Safranek Roman
- Sandell Anna
- Sarav Menaka
- Segarra Alfons
- Serre Jean-Emmanuel
- Singh Harmeet
- Speeckaert Marijn
- Stamellou Eleni
- Stompor Tomasz
- Stoppa Daniela
- Stylianou Konstantinos
- Tennankore Karthik
- Thakar Surabhi
- Tokgoz Bulent
- Toropilov Dmitry
- Toussaint Nigel
- Vaaraniemi Kati
- Vielhauer Volker
- ViganĂČ Sara Maria
- Vladimir Trimarchi
- Vrtovsnik Francois
- Wadhwani Shikha
- Wai Lang
- Wang Caili
- Wang DeGuang
- Wang Jianqin
- Wei Jiali
- Xiong Zuying
- Xu Yan
- Yakubtsevich Ruslan
- Yan Tiekun
- Zermpala Synodi
- Publication venue
- Publication date
- 01/01/2023
- Field of study
The therapeutic potential of a novel, targeted-release formulation of oral budesonide (Nefecon) for the treatment of IgA nephropathy (IgAN) was first demonstrated by the phase 2b NEFIGAN trial. To verify these findings, the phase 3 NefigArd trial tested the efficacy and safety of nine months of treatment with Nefecon (16 mg/d) versus placebo in adult patients with primary IgAN at risk of progressing to kidney failure (ClinicalTrials.gov: NCT03643965). NefIgArd was a multicenter, randomized, double-blind, placebo-controlled two-part trial. In Part A, 199 patients with IgAN were treated with Nefecon or placebo for nine months and observed for an additional three months. The primary endpoint for Part A was 24-hour urine protein-to-creatinine ratio (UPCR) after nine months. Secondary efficacy outcomes evaluated included estimated glomerular filtration rate (eGFR) at nine and 12 months and the UPCR at 12 months. At nine months, UPCR was 27% lower in the Nefecon group compared with placebo, along with a benefit in eGFR preservation corresponding to a 3.87 ml/min/1.73 m2 difference versus placebo (both significant). Nefecon was well-tolerated, and treatment-emergent adverse events were mostly mild to moderate in severity and reversible. Part B is ongoing and will be reported on later. Thus, NefIgArd is the first phase 3 IgA nephropathy trial to show clinically important improvements in UPCR and eGFR and confirms the findings from the phase 2b NEFIGAN study
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia GonzĂĄlez
- Aleem Muhammad
- Alegre InĂȘs
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz AmorĂłs
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-DĂez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado FabĂola
- Amador Cristina GarcĂa
- Amanullah Nazli
- Amaral HĂ©lida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- AndrĂ©s Beatriz DĂaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
- Aytac Erman
- Aytaç Erman
- Azevedo Jose
- Azevedo Patricia
- Azhar Najia
- Aziz Gowhar
- Azman Zairul Azwan Mohd
- AĆkar Ahmet
- Babatunde Olanrewaju
- Badawi Marwa
- Baek Jeong-Heum
- Baez Noelia FernĂĄndez
- Baeza-Murcia Melody
- Bagnardi Francesco
- Baharom Salahudin
- Baik Seung Hyuk
- Baimakhanov Abylai
- Bains Lovenish
- Baker Aleksandra
- Bakmaz Bernarda
- Bala Abubakar Muhammad
- Balaban Vladimir
- Balalis Dimitrios
- Balasubramaniam Dinesh
- Balathayalan Yathev
- Baldi Claudio
- Balestri Riccardo
- Balfour James
- Ballah Abubakar
- Ballian Nikiforos
- Balooshi Iman Al
- Baloyiannis Ioannis
- Bamford Richard
- Bandar Mahdi Al
- Banham Gail
- Bannoud Mohammad Hassan
- Baptista Victor
- Baral Jörg
- Barbalace Nicolas
- Barbato Giuseppe
- Barbosa Anderson
- Bareka Metaxia
- Baris Baver
- Barradas Renato
- Barreda Sara Castillo
- Barrena-Blazquez Silvestra
- Barton Jess
- Bartosiak Katarzyna
- Bashilkina Olga
- Bashir Mohammed
- Basile Raffaele
- Basnyat Pradeep
- Batool Sana
- Bautista Wilson Manuel SĂĄnchez
- Bayhan ZĂŒlfĂŒ
- Bayo José Manuel Muros
- BayĂłn Raquel Ălvaro
- Baños Pedro Antonio Parra
- Beard David
- Bedzhanyan Arkady
- Behilil Chakib
- Bekele Kebebe
- Belarmino Armin
- Belay Million
- Belev Nikolay
- Bellato Vittoria
- BeltrĂĄn de Heredia Juan
- Belvedere Angela
- Benetti Emilio
- Benetti Sara
- Bengueddach Aicha
- Benjelloun El Bachir
- Benkabbou Amine
- Bennett James
- Bensafir Salim
- Bergamini Carlo
- Bernotaite Vlada
- Beron Reinaldo Isaacs
- Bethune Robert
- Bezede Cosmin
- Beznosenko Andriy
- Bhangu Aneel
- Bhargava Aman
- Bhat Rama Rani Krishna
- Bianchi Romina
- Bianco Francesco
- Bigoni Irene
- Binetti Margherita
- Bintintan Vasile
- Biondi Alberto
- Biondo Santino Antonio
- Bisgin Tayfun
- Bisheet George
- Bissett Ian
- Biswas Jyotirmoy
- Blackwell Sue
- Blanco Pablo
- Blanco Raquel RĂos
- Blanco-Colino Ruth
- Blasco Laura Fraile
- Blazquez-Martin Alma
- Bobadilla Billy Jimenez
- Bocancia Raluca
- Boccia Giuseppe
- Bogatikov Alexander
- Bolanle Olajide Edward
- Bomfa-Barbosa Alysson
- Bompou Effrosyni
- Bonardello Michela
- Bonci Eduard-Alexandru
- Bordom Daniel Osei
- Borges Filipe
- Borghi Felice
- Boschiero Matheus Negri
- Bose Bodhisattva
- Bouchagier Konstantinos
- Boudjenan-Serradj Nabil
- Boudoux Sabrina
- Bourazani Maria
- Boyce Stephen
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bradulskis Saulius
- Brainsa Eneida
- Brandström Gustav
- Braumille Markus
- Bravo Ana Minaya
- Bravo Raquel
- Bredikhin Mikhail
- Brito Noelia
- Bruni Andrea
- Buccianti Piero
- Buchs Nicolas
- Buchwald Pamela
- Budnikova Ina
- BudrikienÄ Rima
- Buey Lourdes
- Buijs Louis
- Buleje Jorge Alejandro Benavides
- Burlov Nikita
- Butt Anam
- Byshetty Rajendar
- Bywater Edward
- Bzikha Ilham
- BĂĄnky BalĂĄzs
- BĂŠlum Jens Kristian
- Caballero-Delgado Javier
- Cabrera Claudia
- Cafranga EstĂbaliz GutiĂ©rrez
- Cagnazzo Federica
- Calabria Mariangela
- Calabro' Marcello
- Caliendo Domenico
- Calin Camelia
- Caliskan Cemil
- Callan Rory
- Callari Cosimo
- Caltea Mihaela
- Calvo Almudena Castro
- Camacho Amparo
- Cammarata Francesco
- Campanati Renato
- Campanelli Michela
- Campbell Marion
- Canals LucĂa Otazu
- Canda Aras Emre
- Cano-Matias Auxiliadora
- Cao Victor Hugo Bruno
- Capolupo Gabriella Teresa
- Cappiello Antonio
- Capuano Marianna
- Capusan Alina
- Carannante Filippo
- Carbone Ludovico
- Cardelli Stefano
- Carden Claire
- Cardoso Diogo
- Caricato Marco
- Carlin Patricia Saez
- Carlini Massimo
- Carlos Sandra
- Carneros Virginia Jimenez
- Carosso Fabio
- Caroço Teresa Vieira
- Carpelan Anu
- Carpenter Holly
- Carrascosa-Morales Irene
- Carrie Augusto
- Carrizo Claudia
- Carta Giuseppina
- Carvalho Alexandre
- Carvello Michele
- Casanova Daniel
- Cascais Raquel
- Cassia Gabriela
- Castaldi Antonio
- Castaño Renata
- Castiglioni Simone
- Castillo Enrique Roca
- Castro Marta Cuartero
- Catalano Pablo
- Cato Liam
- Caz Esra
- Cebolla Elena Sagarra
- Cecchini Ilaria
- CeldrĂĄn Rebeca GonzĂĄlez
- Celik Hale Kefeli
- Ceretti Andrea Pisani
- Ceron Silvia Ferrer
- Cervellera Maurizio
- Cervone Carmela
- Chacko Anil
- Chandrasinghe Pramodh
- Charakopoulou Alexandra
- Chardalias Leonidas
- Chaturvedi Arun
- Chatzikomnitsa Paraskevi
- Chaudhari Abhishek
- Chaudhry Sanjay
- Chawla Tabish
- Chee Corissa
- Chen Nevin
- Cheng Kuang I
- Chiarugi Massimo
- Chisthi Meer
- Chitnis Abhishek
- Chitul Andrei
- Chmielewski Gaspard
- Cholewa Hanna
- Chornet Marta RosellĂł
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
- Chung Jun Seong
- Church Robert
- Chwat Carina
- Ciabattari Paula
- Cianchi Fabio
- Cianci Pasquale
- Ciccarese Angelo Antonio
- Ciftci Ahmet Burak
- Cigagna Luca
- Cini Charles
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- Wickramarathne Rasika
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- Widatalla Abu Bakr H
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- Wilson Jeremy
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- Wright Jonathan
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- Yadav Ram Kishan
- Yadev I P
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- Yalkin Ămer
- Yanishev Alexey
- Yao Hongwei
- Yazici Pinar
- Yemez Kursat
- Yew Chor Kuan
- Yılmaz GĂŒlseren
- Yilmazlar Tuncay
- YiÄit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)
Progression of Geographic Atrophy in Age-related Macular Degeneration
- Author
- A. Christine Hoerner
- Aaron Parnes
- Aaron Weinberg
- Abraham Poulose
- Adam Berger
- Adam Gerstenblith
- Adam Smucker
- Adam Zamboni
- Adelia Castano
- Alan J. Ruby
- Alan J. Ruby
- Alan J. Ruby
- Alan Kimura
- Alan Letson
- Alan R. Margherio
- Alana Temple
- Albert M. Maguire
- Albert Sinyai
- Albert Vitale
- Alessandro Iannaccone
- Alexander J. Brucker
- Alice Henning
- Alice Lyon
- Alice T. Lyon
- Alicia Disgdiertt
- Alicia Zetina
- Alison Nowak
- Allan Hunter
- Allan Kreiger
- Allen C. Ho
- Alycia Fleming
- Alysia Cronise
- Amanda Butt
- Amanda Fec
- Amanda Milliron
- Amberly Rodriguez
- Amelia Stokely
- Amitha Domalpally
- Amitha Domalpally
- Amy Flowers
- Amy Frost
- Amy Noffke
- Anand Swaroop
- Anderson
- Andrea Czubinski
- Andrea Degillio
- Andrea Menzel
- Andreas Lauer
- Andrew Antoszyk
- Andrew Eller
- Andrew Hendrick
- Andrew Moshfeghi
- Angel Garced
- Angela Marsh
- Angela Price
- Angelia Johnson
- Angella Karow
- Angie McDowell
- Angie Wealti
- Anita Agarwal
- Ann Marie Lane
- Ann Marie Lavorna
- Ann Miller
- Ann Wasilus
- Anne Fung
- Anne Haroldsen
- Anne Lindblad
- Anthony Medina
- Antonio Capone
- AREDS2 Research Group
- Aron Gedansky
- Arthur D. Fu
- Ashaki Meeks
- Asheesh Tewari
- Ashley Davis
- Ashley Emerson
- Atul Sharma
- Babilonia Ayukawa
- Barbara A. Blodi
- Barbara Blodi
- Barbara Burger
- Barbara Campbell
- Barbara Holderreed
- Barbara Jennings
- Barbara Johnson
- Barbara McGinley
- Barbara Nardi
- Barbara Soderling
- Barbara Taylor
- Barron C. Fishburne
- Barry Taney
- Bawa Dass
- Belen Rodriguez
- Benjamin Kim
- Benjamin Nicholson
- Bernard Doft
- Beth Malpica
- Beverly Sannazzaro
- Biarnes
- Bill Nyberg
- Bird
- Blaine Cribbs
- Bob Boleman
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- John Wells
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- Jorge Rodriguez
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- Joseph F. Fisher
- Joseph Fan
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- Joy Bankert
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- Khanifar
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- Klein
- Klein
- Klein
- Komal Desai
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- Krissa Packard
- Krista Bayer
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- Kristin Lipka
- Kristina Oliver
- Kristine Dietzman
- Kristine Johnson
- Kristy Keller
- Kumar Thotapally
- Kylie Mendez
- Lacy Stover
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- Laura Holm
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- Levy
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- Manjot Gill
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- Ong
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- Paula Price
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- Peggy Miller
- Peter MacDowell
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- Philip J. Rosenfeld
- Philip Laird
- Philip Rosenfeld
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- Qin Zhou
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- Ricky D. Isernhagen
- Rinki Ratnapriya
- Rishi Doshi
- Rita Denbow
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- Riva Adamovsky
- Rob Richmond
- Robbin Spivey
- Robert A. Liss
- Robert A. Stoltz
- Robert Bergren
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- Robert E. Leonard
- Robert Frantz
- Robert H. Rosa
- Robert Lindblad
- Robert Masini
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- Robert Murphy
- Robert N. Frank
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- Roisman
- Ron Adelman
- Rona Lyn Esquejo-Leon
- Ronald G. Danis
- Ronald Gentile
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- Ronald Klein
- Ronald Klein
- Ronald P. Danis
- Ronald P. Danis
- Rosa Rodriguez
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- Rosaleen Ostrick
- Roula Nashwinter
- Royce Chen
- Rudnicka
- Rukhsana Mizra
- Russ Burris
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- Ryan Hollman
- Sadda
- Sadda
- Sally Arceneaux
- Sam Pistorius
- Sami Uwaydat
- Sandeep Grover
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- Sandra Reed
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- Sandy Lash
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- Sara Henderson
- Sara J. Schmidt
- Sarah Brett
- Sarah Ennis
- Sarah Gould
- Sarah Oelrich
- Sashi Kaur
- Schaal
- Schmitz-Valckenberg
- Schmitz-Valckenberg
- Scott Anagnoste
- Scott Lampert
- Scott Pendergast
- Scott Savage
- Scott Sneed
- Sean Grout
- Sean Koh
- Seema Garg
- Serena Neal
- Shailesh Gupta
- Shane Mowry
- Shannon Howard
- Shannya Townsend-Patrick
- Sharon Murajda-Jumba
- Sharon Solomon
- Shawn Wilker
- Sheila Smith-Brewer
- Shelly Fulbright
- Shelly Olson
- Sheri Drossner
- Sherrie Schenning
- Sherry Fredenberg
- Sherry L. Hadley
- Shree Kurup
- Silvia Linares
- Sleiman
- Smiley Hom
- Sohail Hasan
- Sonia Mehta
- Sonny Icks
- Sophie J. Bakri
- SriniVas Sadda
- SriniVas Sadda
- Stacie Hrvatin
- Starr Hendricks
- Stefani Karakas
- Stefanie Carey
- Stefanie Schuman
- Stephanie Burke
- Stephanie Hatch Smith
- Stephanie Thatcher
- Stephanie Vanderveldt
- Stephen Hobbs
- Stephen Perkins
- Stephen Petty
- Stephen Russell
- Steve Rauch
- Steven Bennett
- Steven H. Sherman
- Steven Lin
- Steven Schwartz
- Steven Spencer
- Steven T. Bailey
- Steven Truong
- Steven Yeh
- Suber Huang
- Sue Pope
- Suk Jin Moon
- Sun
- Sunir Garg
- Sunness
- Sunness
- Sunness
- Suresh Chandra
- Susan Allman
- Susan B. Bressler
- Susan Geraghty
- Susan Jones
- Susan Rath
- Susanna Soon-Chun Park
- Susie Chang
- Swaroop
- Sylvia Ramos
- T. Michael Nork
- Tamara Cunningham
- Tametha Johnson
- Tammy Brink
- Tammy Eileen Lo
- Tammy Gasparyan
- Tammy Walker
- Tana Williams
- Tanya Alexander Snowden
- Tanya Tracy Marsh
- Tara Farmer
- Tara Raphael
- Tara Young McCannel
- Tarek S. Hassan
- Tatiana Mikheyav
- Teresa Coffey
- Teresa Slagle
- Tereza Conway
- Theresa Cain
- Theresa Goddard
- Thomas B. Connor
- Thomas Blondo
- Thomas Friberg
- Thomas G. Chu
- Thomas J. Hwang
- Thomas Link
- Thomas R. Pheasant
- Thomas S. Stevens
- Thomas W. Stone
- Tiana Gonzales
- Tiarnan D. Keenan
- Tien Pei Wong
- Tiffanie Keaton
- Tiffany Swinford
- Tim Odem
- Timothy Bennett
- Timothy Olsen
- Tina Bell
- Tina Scheufele Cleary
- Tod A. McMillan
- Todd E. Schneiderman
- Tom Treuter
- Tony Adkins
- Torsten Wiegand
- Tracey Caldwell
- Tracey Martin
- Traci Clemons
- Traci E. Clemons
- Tracy Emond
- Tracy Kaczanowski
- Tracy Murray
- Tracy Troszak
- Travis Meredith
- Trexler Topping
- Trina Nitzsche
- Uma Balasubramaniam
- Ursula Lord Bator
- Valerie Davis
- Valerie Watson
- Vanessa Bergman
- Vanessa Denny
- Vanessa Hoelscher
- Vera Dilts
- Veronica Sneed
- Vesper Williams
- Vicki Barwick
- Victoria Donaldson
- Vinad Voleti
- Virginia Therrien
- Vivian Tanner
- W. Copley McLean
- W. Scott Thompson
- W. Zachery Bridges
- Wai T. Wong
- Wai T. Wong
- Waldemar Torres
- Walter Holland
- Wanda Carrasquillo-Boyd
- Wang
- Wayne A. Solley
- Wendy McBee
- Wenhua Li
- Willia Ingram
- William Anderson
- William Deegan
- William J. Wirostko
- William J. Wood
- William Kiernan
- William Rosenthal
- William Tasman
- Yaspan
- Yehoshua
- Yehoshua
- Yehoshua
- Yehoshua
- Yesenia Ovando
- Yesmin Urias
- Yin Chen
- Yolanda Konior
- Yu
- Yu-Guang He
- Zayna Nahas
- Zbigniew Krason
- Zlatan Sadikovic
- Zohar Yehoshua
- Zuzanna Rozenbajgier
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study