Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell

PubMed ID: 23592993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Génétique des populations du nématode Caenorhabditis elegans

Caenorhabditis elegans, un nématode libre androdioïque, est un des organismes modèles les plus utilisés en biologie. C. elegans était pourtant peu utilisé en biologie de l évolution jusqu à récemment. Après la mise au point un protocole d isolement, nous avons isolé plusieurs populations naturelles de C. elegans et montré que cette espèce prolifère dans la matière organique en décomposition. La diversité nucléotidique au sein des populations est élevée par rapport à la diversité à l échelle de la France, de l ordre de 0,8 x 10-3, correspondant à une population efficace de 104 individus. La structure des populations est forte, même à petite échelle. Le suivi de plusieurs populations naturelles au cours du temps a mis en évidence une dynamique de métapopulation. Nous avons montré que le taux de croisement dans les populations naturelles est faible, entre 10-2 et 10-4 par génération. Nos données suggèrent l existence de dépression hybride dans les populations naturellesPARIS-BIUSJ-Thèses (751052125) / SudocPARIS-BIUSJ-Physique recherche (751052113) / SudocSudocFranceF

Le diabète gestationnel (nouvelles recommandations 2012)

La problématique du diabète gestationnel est telle que les stratégies de dépistage et de diagnostic du diabète gestationnel ont longtemps fait l'objet de critiques et sont restées très hétérogènes tant au niveau national qu'international. Grace aux résultats de l'étude Hyperglycemia And Pregnancy Outcome (HAPO) et la volonté internationale d'uniformiser les critères de dépistage et de diagnostic, l'International Association of Diabetes and Pregnancy Study Groups (IADPSG) a émis des recommandations relatives aux nouvelles méthodes diagnostiques du diabète gestationnel. Cette thèse étudie en détail les nouvelles recommandations de dépistage et de diagnostic du diabète gestationnel en 2012, les conséquences qu'elles entrainent et les avancées actuelles qu'il existe dans la prise en charge du diabète gestationnel.NANTES-BU Médecine pharmacie (441092101) / SudocSudocFranceF

Electronic interaction between two fluorenyl-bridged molybdenocene dithiolene electroactive centers

International audienceA bimetallic metal complex involving a fluorene linker between two redox active bis(cyclopentadienyl)molybdenum dithiolene moieties has been synthesized and characterized by electrochemistry and spectroelectrochemistry. Cyclic voltammetry experiments show sequential oxidation of the two redox centers with small ΔE values between the first and the second redox processes and between the third and the fourth ones. Comparative electrochemical studies carried out using either [NBu4][PF6] or the poorly coordinating supporting electrolyte [Na][B(C6H4(CF3)2)4] in dichloromethane indicate strong electrostatic effects on consecutive electron transfers, especially for highly charged species. Spectroelectrochemical investigations together with DFT calculations evidence that the two molybdenocene dithiolene electrophores are weakly electronically coupled through the organic bridge. © 2022 Elsevier Lt

Electronic Interplay between TTF and Extended-TCNQ Electrophores along a Ruthenium Bis(acetylide) Linker

International audienceA bis(TTF-butadiynyl) ruthenium D-D'-D complex, with intramolecular electronic interplay between the three electron-donating electrophores, was easily converted through a cycloaddition-retroelectrocyclization with TCNQ into a D-A-D'-A-D pentad complex, which exhibits an intense intramolecular charge transfer together with an electronic interplay between the two acceptors along the conjugated organometallic bridge

Electronic Communication within Flexible Bisdithiolene Ligands Bridging Molybdenum Centers

International audienceBimetallic molybdenum dithiolene complexes involving two flexible ditopic conjugated linkers have been synthesized and characterized by electrochemistry, spectroelectrochemistry, and single crystal X-ray diffraction. The electrochemical investigations evidence that the two metallic bisdithiolene moieties are electronically coupled in the monocationic state. DFT and TDDFT calculations further suggest that the intervalence charge transfer within both monocations is essentially localized on the ligand and can be described as an intraligand charge transfer (ILCT)

Electrochemical Activation of TTF-Based Halogen Bond Donors A Powerful, Selective and Sensitive Analytical Tool for Probing a Weak Interaction in Complex Media

International audienceHerein we demonstrate the electrochemical activation and detection of intermolecular halogen bonding (XB) in solution by generating the cation radical of iodo-trimethyltetrathiafulvalene (I-Me3TTF center dot(+)) in the presence of various Lewis-basic anions. This work is leading to the endorsement and generalization of the concept of electrostimulating XB for molecular recognition by adjusting the properties of the XB donor via the electrochemical reversible generation of charged species. The formation of the interaction between I-Me3TTF center dot+ and Lewis bases has been investigated by cyclic voltammetry allowing to quantify the strength of the interaction (K-ox = 100 to 400 M-1 and Delta G = -12 to -15 kJ mol(-1)). Moreover spectroelectrochemical measurements along with TD-DFT calculations have confirmed XB formation upon generation of the radical cation. The present work opens broad perspectives for the development of redox switchable XB donors in the field of molecular recognition in chemical and biological systems where non-covalent interactions are usually key governing parameters