1,734 research outputs found
Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT)
Background: The Canadian Study of Prediction of Death, Dialysis and Interim Cardiovascular Events (CanPREDDICT)
is a large, prospective, pan-Canadian, cohort study designed to improve our understanding of determinants of renal and cardiovascular (CV) disease progression in patients with chronic kidney disease (CKD). The primary objective is to clarify the associations between traditional and newer biomarkers in the prediction of specific renal and CV events, and of death in patients with CKD managed by nephrologists. This information could then be used to better understand biological variation in outcomes, to develop clinical prediction models and to inform enrolment into interventional studies which may lead to novel treatments.
Methods/Designs: Commenced in 2008, 2546 patients have been enrolled with eGFR between 15 and 45 ml/min 1.73m2 from a representative sample in 25 rural, urban, academic and non academic centres across Canada. Patients are to be followed for an initial 3 years at 6 monthly intervals, and subsequently annually. Traditional biomarkers include eGFR, urine albumin creatinine ratio (uACR), hemoglobin (Hgb), phosphate and albumin. Newer biomarkers of interest were selected on the basis of biological relevance to important processes, commercial availability and assay reproducibility. They include asymmetric dimethylarginine (ADMA), N-terminal pro-brain natriuretic peptide (NT-pro-BNP), troponin I, cystatin C, high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL6) and transforming growth factor beta 1 (TGFβ1). Blood and urine samples are collected at baseline, and every 6 monthly, and stored at −80°C. Outcomes of interest include renal replacement therapy, CV events and death, the latter two of which are adjudicated by an independent panel.
Discussion: The baseline distribution of newer biomarkers does not appear to track to markers of kidney function
and therefore may offer some discriminatory value in predicting future outcomes. The granularity of the data
presented at baseline may foster additional questions.
The value of the cohort as a unique resource to understand outcomes of patients under the care of nephrologists
in a single payer healthcare system cannot be overstated. Systematic collection of demographic, laboratory and
event data should lead to new insights.
The mean age of the cohort was 68 years, 90% were Caucasian, 62% were male, and 48% had diabetes. Forty
percent of the cohort had eGFR between 30–45 mL/min/1.73m2, 22% had eGFR values below 20 mL/min/1.73m2; 61% had uACR < 30. Serum albumin, hemoglobin, calcium and 25-hydroxyvitamin D (25(OH)D) levels were progressively lower in the lower eGFR strata, while parathyroid hormone (PTH) levels increased. Cystatin C, ADMA, NT-proBNP, hsCRP, troponin I and IL-6 were significantly higher in the lower GFR strata, whereas 25(OH)D and TGFβ1 values were lower at lower GFR. These distributions of each of the newer biomarkers by eGFR and uACR categories were variable
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The utility of convection-permitting ensembles for the prediction of stationary convective bands
This study examines convection-permitting numerical simulations of four cases of terrain-locked quasi-stationary convective bands over the UK. For each case, a 2.2-km grid-length 12-member ensemble and 1.5-km grid-length deterministic forecast are analyzed, each with two different initialization times. Object-based verification is applied to determine whether the simulations capture the structure, location, timing, intensity and duration of the observed precipitation. These verification diagnostics reveal that the forecast skill varies greatly between the four cases. Although the deterministic and ensemble simulations captured some aspects of the precipitation correctly in each case, they never simultaneously captured all of them satisfactorily. In general, the models predicted banded precipitation accumulations at approximately the correct time and location, but the precipitating structures were more cellular and less persistent than the coherent quasi-stationary bands that were observed. Ensemble simulations from the two different initialization times were not significantly different, which suggests a potential benefit of time-lagging subsequent ensembles to increase ensemble size. The predictive skill of the upstream larger-scale flow conditions and the simulated precipitation on the convection-permitting grids were strongly correlated, which suggests that more accurate forecasts from the parent ensemble should improve the performance of the convection-permitting ensemble nested within it
Positivity of Spin Foam Amplitudes
The amplitude for a spin foam in the Barrett-Crane model of Riemannian
quantum gravity is given as a product over its vertices, edges and faces, with
one factor of the Riemannian 10j symbols appearing for each vertex, and simpler
factors for the edges and faces. We prove that these amplitudes are always
nonnegative for closed spin foams. As a corollary, all open spin foams going
between a fixed pair of spin networks have real amplitudes of the same sign.
This means one can use the Metropolis algorithm to compute expectation values
of observables in the Riemannian Barrett-Crane model, as in statistical
mechanics, even though this theory is based on a real-time (e^{iS}) rather than
imaginary-time (e^{-S}) path integral. Our proof uses the fact that when the
Riemannian 10j symbols are nonzero, their sign is positive or negative
depending on whether the sum of the ten spins is an integer or half-integer.
For the product of 10j symbols appearing in the amplitude for a closed spin
foam, these signs cancel. We conclude with some numerical evidence suggesting
that the Lorentzian 10j symbols are always nonnegative, which would imply
similar results for the Lorentzian Barrett-Crane model.Comment: 15 pages LaTeX. v3: Final version, with updated conclusions and other
minor changes. To appear in Classical and Quantum Gravity. v4: corrects # of
samples in Lorentzian tabl
Spin Foam Models of Riemannian Quantum Gravity
Using numerical calculations, we compare three versions of the Barrett-Crane
model of 4-dimensional Riemannian quantum gravity. In the version with face and
edge amplitudes as described by De Pietri, Freidel, Krasnov, and Rovelli, we
show the partition function diverges very rapidly for many triangulated
4-manifolds. In the version with modified face and edge amplitudes due to Perez
and Rovelli, we show the partition function converges so rapidly that the sum
is dominated by spin foams where all the spins labelling faces are zero except
for small, widely separated islands of higher spin. We also describe a new
version which appears to have a convergent partition function without drastic
spin-zero dominance. Finally, after a general discussion of how to extract
physics from spin foam models, we discuss the implications of convergence or
divergence of the partition function for other aspects of a spin foam model.Comment: 23 pages LaTeX; this version to appear in Classical and Quantum
Gravit
Interface-mediated ferroelectric patterning and Mn valency in nano-structured PbTiO <sub>3</sub> /La <sub>0.7</sub> Sr <sub>0.3</sub> MnO <sub>3</sub>
International audienceWe employed a multitechnique approach using piezo-force response microscopy and photoemission microscopy to investigate a self-organizing polarization domain pattern in PbTiO3/La0.7Sr0.3MnO3 (PTO/LSMO) nanostructures. The polarization is correlated with the nanostructure morphology as well as with the thickness and Mn valence of the LSMO template layer. On the LSMO dots, the PTO is upwards polarized, whereas outside the nanodots, the polarization appears both strain and interface roughness dependent. The results suggest that the electronic structure and strain of the PTO/LSMO interface contribute to determining the internal bias of the ferroelectric layer
Use of bisulfite processing to generate high-β-O-4 content water-soluble lignosulfonates
This work was supported by EPSRC grants (EP/1518175), the Industrial Biotechnology Innovation Centre (IBioIC) (DMB Ph.D. studentship) and an EPSRC Doctoral Prize Fellowship (CSL).With lignin-first biorefineries likely to become a reality, controlled depolymerization of high-quality lignin streams to high value products has become a priority. Using bisulfite chemistry, access to a high-β-O-4 content water-soluble lignosulfonate has been achieved, allowing follow-on procedures in water to be conducted. We show that phenolic β-O-4 units preferential-ly react under acidic bisulfite conditions, whilst non-phenolic β-O-4 units react much more slowly. Exploiting this improved chemical understanding and inherent selectivity, a softwood lignosulfonate has been prepared in which phenolic β-O-4 α-sulfonation has occurred leaving significant native β-O-4 content. Use of an O-benzoylation protocol with lignin coupled with advanced 2D NMR methods has allowed detailed analysis of this and other commercial and industrial lignosulfonates. Conversion of the native β-O-4 to benzylic- oxidized β-O-4 units was followed by a selective reductive cleavage to give a premium aromatic monomer in pure form.Publisher PDFPeer reviewe
MF2293
Fadi Aramouni et al, Food safety, Kansas State University, October 1997
Scleromochlus and the early evolution of Pterosauromorpha
Pterosaurs, the first vertebrates to evolve powered flight, were key components of Mesozoic terrestrial ecosystems from their sudden appearance in the Late Triassic until their demise at the end of the Cretaceous1,2,3,4,5,6. However, the origin and early evolution of pterosaurs are poorly understood owing to a substantial stratigraphic and morphological gap between these reptiles and their closest relatives6, Lagerpetidae7. Scleromochlus taylori, a tiny reptile from the early Late Triassic of Scotland discovered over a century ago, was hypothesized to be a key taxon closely related to pterosaurs8, but its poor preservation has limited previous studies and resulted in controversy over its phylogenetic position, with some even doubting its identification as an archosaur9. Here we use microcomputed tomographic scans to provide the first accurate whole-skeletal reconstruction and a revised diagnosis of Scleromochlus, revealing new anatomical details that conclusively identify it as a close pterosaur relative1 within Pterosauromorpha (the lagerpetid + pterosaur clade). Scleromochlus is anatomically more similar to lagerpetids than to pterosaurs and retains numerous features that were probably present in very early diverging members of Avemetatarsalia (bird-line archosaurs). These results support the hypothesis that the first flying reptiles evolved from tiny, probably facultatively bipedal, cursorial ancestors1
Mean curvature flow with triple junctions in higher space dimensions
We consider mean curvature flow of n-dimensional surface clusters. At
(n-1)-dimensional triple junctions an angle condition is required which in the
symmetric case reduces to the well-known 120 degree angle condition. Using a
novel parametrization of evolving surface clusters and a new existence and
regularity approach for parabolic equations on surface clusters we show local
well-posedness by a contraction argument in parabolic Hoelder spaces.Comment: 31 pages, 2 figure
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